Title:
NOVEL ANTIBODY BINDING TO TFPI AND COMPOSITION COMPRISING THE SAME
Document Type and Number:
WIPO Patent Application WO/2016/137108
Kind Code:
A1
Abstract:
The present invention relates to an antibody that binds specifically to a tissue factor pathway inhibitor (TFPI), a nucleic acid encoding the antibody, a vector comprising the nucleic acid, a host cell transformed with the vector, a method for producing the antibody, and a pharmaceutical composition for treating hemophilia, which comprises the antibody as an active ingredient. The antibody of the present invention, which binds specifically to TFPI, can activate the extrinsic pathway of blood coagulation by inhibiting TFPI. Thus, the antibody of the present invention can be effectively used for the treatment of antibody-induced hemophilia patients and for the prevention of blood coagulation disease in hemophilia-A or hemophilia-B patients.
Inventors:
KIM DONG-SIK (KR)
LEE MI JUNG (KR)
PARK JAE CHAN (KR)
LEE SUMIN (KR)
KWAK HEECHUN (KR)
HWANG SUNGHO (KR)
LIM HYUNG-KWON (KR)
KIM KISU (KR)
PARK YOUNG SEOUB (KR)
JEONG JUNHONG (KR)
CHO KI JOON (KR)
LEE MI JUNG (KR)
PARK JAE CHAN (KR)
LEE SUMIN (KR)
KWAK HEECHUN (KR)
HWANG SUNGHO (KR)
LIM HYUNG-KWON (KR)
KIM KISU (KR)
PARK YOUNG SEOUB (KR)
JEONG JUNHONG (KR)
CHO KI JOON (KR)
Application Number:
PCT/KR2015/014370
Publication Date:
September 01, 2016
Filing Date:
December 29, 2015
Export Citation:
Assignee:
MOGAM BIOTECHNOLOGY INST (KR)
International Classes:
C07K16/36; A61K39/395; A61P7/04; C12N15/63
Domestic Patent References:
| WO2010017196A2 | 2010-02-11 | |||
| WO2011109452A1 | 2011-09-09 |
Foreign References:
| US20140275493A1 | 2014-09-18 |
Other References:
DATABASE NCBI 3 December 2012 (2012-12-03), Database accession no. XP_004032982 .1
MARONEY ET AL.: "Absence of hematopoietic tissue factor pathway inhibitor mitigates bleeding in mice with hemophilia", PNAS, vol. 109, no. 10, 2012, pages 3927 - 3931, XP055461362
See also references of EP 3262075A4
MARONEY ET AL.: "Absence of hematopoietic tissue factor pathway inhibitor mitigates bleeding in mice with hemophilia", PNAS, vol. 109, no. 10, 2012, pages 3927 - 3931, XP055461362
See also references of EP 3262075A4
Attorney, Agent or Firm:
LEE, Cheo Young et al. (123 Teheran-roGangnam-gu, Seoul, KR)
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