Title:
NOVEL ANTIBODY USEFUL IN NEUROLOGICAL OR NEURODEGENERATIVE DISORDERS
Document Type and Number:
WIPO Patent Application WO/2014/187879
Kind Code:
A3
Abstract:
The present invention relates to an anti-NMDA antibody or fragment or derivative thereof which is effective in inhibiting the deleterious effects of tissue-type plasminogen activator (t-PA) mediated by N-methyl-D-aspartate (NMDA) receptors and to medical uses, in particular for the treatment of neurological or neurodegenerative disorders, e.g. multiple sclerosis.
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Inventors:
DOCAGNE FABIAN (FR)
MACREZ RICHARD (FR)
VIVIEN DENIS (FR)
PETERSEN KARL-UWE (DE)
MACREZ RICHARD (FR)
VIVIEN DENIS (FR)
PETERSEN KARL-UWE (DE)
Application Number:
PCT/EP2014/060486
Publication Date:
January 22, 2015
Filing Date:
May 21, 2014
Export Citation:
Assignee:
PAION DEUTSCHLAND GMBH (DE)
INST NAT SANTE RECH MED (FR)
INST NAT SANTE RECH MED (FR)
International Classes:
C07K16/28; A61P9/10; A61P25/00
Domestic Patent References:
| WO2011023250A1 | 2011-03-03 |
Other References:
THOMAS GABEREL ET AL: "Immunotherapy blocking the tissue plasminogen activator-dependent activation of N-methyl-d-aspartate glutamate receptors improves hemorrhagic stroke outcome", NEUROPHARMACOLOGY, vol. 67, 1 April 2013 (2013-04-01), pages 267 - 271, XP055058881, ISSN: 0028-3908, DOI: 10.1016/j.neuropharm.2012.11.023
MACREZ R ET AL: "Antibodies Preventing the Interaction of Tissue-Type Plasminogen Activator With N-Methyl-D-Aspartate Receptors Reduce Stroke Damages and Extend the Therapeutic Window of Thrombolysis", STROKE, LIPPINCOTT WILLIAMS & WILKINS, US, vol. 42, no. 8, 1 August 2011 (2011-08-01), pages 2315 - 2322, XP002684999, ISSN: 0039-2499, [retrieved on 20110616], DOI: 10.1161/STROKEAHA.110.606293
MÓNICA FERNÁNDEZ-MONREAL ET AL: "Arginine 260 of the amino-terminal domain of NR1 subunit is critical for tissue-type plasminogen activator-mediated enhancement of N-methyl-D-aspartate receptor signaling", vol. 279, no. 49, 3 December 2004 (2004-12-03), pages 50850 - 50856, XP002695138, ISSN: 0021-9258, Retrieved from the Internet [retrieved on 20040923], DOI: 10.1074/JBC.M407069200
SUREKHA DIPAK AMRUTKAR ET AL: "-aspartate receptor reveals a short linear epitope", BIOPOLYMERS, vol. 98, no. 6, 12 November 2012 (2012-11-12), pages 567 - 575, XP055102219, ISSN: 0006-3525, DOI: 10.1002/bip.22165
ANONYMOUS: "Datasheet SC-9058", INTERNET CITATION, 1 January 2006 (2006-01-01), pages 1, XP002591364, Retrieved from the Internet [retrieved on 20100709]
MACREZ R ET AL: "Antibodies Preventing the Interaction of Tissue-Type Plasminogen Activator With N-Methyl-D-Aspartate Receptors Reduce Stroke Damages and Extend the Therapeutic Window of Thrombolysis", STROKE, LIPPINCOTT WILLIAMS & WILKINS, US, vol. 42, no. 8, 1 August 2011 (2011-08-01), pages 2315 - 2322, XP002684999, ISSN: 0039-2499, [retrieved on 20110616], DOI: 10.1161/STROKEAHA.110.606293
MÓNICA FERNÁNDEZ-MONREAL ET AL: "Arginine 260 of the amino-terminal domain of NR1 subunit is critical for tissue-type plasminogen activator-mediated enhancement of N-methyl-D-aspartate receptor signaling", vol. 279, no. 49, 3 December 2004 (2004-12-03), pages 50850 - 50856, XP002695138, ISSN: 0021-9258, Retrieved from the Internet
SUREKHA DIPAK AMRUTKAR ET AL: "-aspartate receptor reveals a short linear epitope", BIOPOLYMERS, vol. 98, no. 6, 12 November 2012 (2012-11-12), pages 567 - 575, XP055102219, ISSN: 0006-3525, DOI: 10.1002/bip.22165
ANONYMOUS: "Datasheet SC-9058", INTERNET CITATION, 1 January 2006 (2006-01-01), pages 1, XP002591364, Retrieved from the Internet
Attorney, Agent or Firm:
VON RENESSE, Dorothea et al. (Düsseldorf, DE)
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