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Title:
NOVEL ANTICANCER AGENT
Document Type and Number:
WIPO Patent Application WO/2015/190489
Kind Code:
A1
Abstract:
 The purpose of the present invention is to provide a useful prodrug compound of a naphthofuran compound. The present invention pertains to a compound represented by general formula (IA): (the symbols in the formula are as stated in the specification) or a pharmacologically acceptable salt thereof.

Inventors:
YOSHIMURA, Yoshinobu (38, Nishinokyo Tsukinowa-cho, Nakagyo-ku, Kyoto-sh, Kyoto 44, 〒6048444, JP)
KASAI, Masayasu (38, Nishinokyo Tsukinowa-cho, Nakagyo-ku, Kyoto-sh, Kyoto 44, 〒6048444, JP)
SHOJI, Yoshimichi (38, Nishinokyo Tsukinowa-cho, Nakagyo-ku, Kyoto-sh, Kyoto 44, 〒6048444, JP)
TAKEDA, Shigemitsu (38, Nishinokyo Tsukinowa-cho, Nakagyo-ku, Kyoto-sh, Kyoto 44, 〒6048444, JP)
Application Number:
JP2015/066625
Publication Date:
December 17, 2015
Filing Date:
June 09, 2015
Export Citation:
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Assignee:
KYOTO PHARMACEUTICAL INDUSTRIES, LTD. (38 Nishinokyo Tsukinowa-cho, Nakagyo-ku Kyoto-sh, Kyoto 44, 〒6048444, JP)
International Classes:
C07D307/92; A61K31/343; A61K31/351; A61K31/357; A61K31/397; A61K31/41; A61K31/4192; A61K31/443; A61K31/4525; A61K31/496; A61K31/5375; A61K31/7012; A61K31/7024; A61P35/00; C07D405/12; C07D407/12; C07H13/10; C07H15/26
Foreign References:
JP2013522326A2013-06-13
JP2013522325A2013-06-13
JP2010539098A2010-12-16
JP2010539097A2010-12-16
JP2010539095A2010-12-16
Other References:
ALEXANDRA REICHSTEIN ET AL.: "Synthesis and Structure-Activity Relationships of Lapacho Analogues. 1. Suppression of Human Keratinocyte Hyperproliferation by 2-Substituted Naphtho [2,3-b]furan-4, 9-diones, Activation by Enzymatic One- and Two-Electron Reduction, and Intracellular Generation of Superoxide", JOURNAL OF MEDICINAL CHEMISTRY, vol. 55, 2012, pages 7273 - 7284, XP055244777
KUCKLAENDER UWE: "Mechanism of the Nenitzescu reaction, V. Synthesis of naphthofuran derivatives", JUSTUS LIEBIGS ANNALEN DER CHEMIE, vol. 1, 1978, pages 140 - 149, XP055123771
See also references of EP 3153508A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime (Meiji Yasuda Seimei Osaka Midosuji Bldg, 1-1 Fushimimachi 4-chome, Chuo-ku, Osaka-sh, Osaka 44, 〒5410044, JP)
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