Title:
NOVEL ANTIMICROBIAL PEPTIDE DERIVED FROM LL37 PEPTIDE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/172666
Kind Code:
A1
Abstract:
The present invention relates to a novel antimicrobial peptide derived from an LL37 peptide and a use thereof. The antimicrobial peptide of the present invention shows excellent antimicrobial activity against gram-positive bacteria, gram-negative bacteria, and antibiotic-resistant bacteria and exhibits low cytotoxicity against cells from mice and humans, and therefore, the antimicrobial peptide may be utilized as an active ingredient of antibiotics, cosmetic compositions, food additives, feed additives, and biological pesticides for antimicrobial use.
Inventors:
PARK YOONKYUNG (KR)
PARK EUNJI (KR)
PARK EUNJI (KR)
Application Number:
PCT/KR2019/002633
Publication Date:
September 12, 2019
Filing Date:
March 07, 2019
Export Citation:
Assignee:
UNIV CHOSUN IACF (KR)
International Classes:
C07K7/08; A01N63/00; A23K20/147; A23L3/3463; A23L3/3526; A61K8/64; A61K38/00; A61P31/04; A61Q17/00; A61Q19/00
Foreign References:
| US20100048480A1 | 2010-02-25 |
Other References:
NELL, MARJA J. ET AL.: "Development of novel LL-37 derived antimicrobial peptides with LPS and LTA neutralizing and antimicrobial activities for therapeutic application", PEPTIDES, vol. 27, 2006, pages 649 - 660
NAGAOKA, I. ET AL.: "Augmentation of the lipopolysaccharide-neutralizing activities of human cathelicidin CAP18/LL-37-derived antimicrobial peptides by replacement with hydrophobic and cationic amino acid residues", CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, vol. 9, no. 5, 2002, pages 972 - 982, XP002255066, doi:10.1128/CDLI.9.5.972-982.2002
NAGAOKA, I. ET AL.: "Augmentation of the bactericidal activities of human cathelicidin CAP18/LL-37-derived antimicrobial peptides by amino acid substitutions", INFLAMMATION RESEARCH, vol. 54, 2005, pages 66 - 73, XP019200355, doi:10.1007/s00011-004-1323-8
GUO, YIJIE ET AL.: "Antimicrobial and Antibiofilm Activity of Human Cationic Antibacterial Peptide (LL-37) and Its Analogs Against Pan-Drug-Resistant Acinetobacterbaumanii", JUNDISHAPUR JOURNAL OF MICROBIOLOGY, vol. 10, no. 3, 2017, pages 1 - 17
NAGAOKA, I. ET AL.: "Augmentation of the lipopolysaccharide-neutralizing activities of human cathelicidin CAP18/LL-37-derived antimicrobial peptides by replacement with hydrophobic and cationic amino acid residues", CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, vol. 9, no. 5, 2002, pages 972 - 982, XP002255066, doi:10.1128/CDLI.9.5.972-982.2002
NAGAOKA, I. ET AL.: "Augmentation of the bactericidal activities of human cathelicidin CAP18/LL-37-derived antimicrobial peptides by amino acid substitutions", INFLAMMATION RESEARCH, vol. 54, 2005, pages 66 - 73, XP019200355, doi:10.1007/s00011-004-1323-8
GUO, YIJIE ET AL.: "Antimicrobial and Antibiofilm Activity of Human Cationic Antibacterial Peptide (LL-37) and Its Analogs Against Pan-Drug-Resistant Acinetobacterbaumanii", JUNDISHAPUR JOURNAL OF MICROBIOLOGY, vol. 10, no. 3, 2017, pages 1 - 17
Attorney, Agent or Firm:
CHOI, Kyu Whan (KR)
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