Title:
NOVEL ARYLAMIDINE DERIVATIVE OR SALT THEREOF
Document Type and Number:
WIPO Patent Application WO/2003/074476
Kind Code:
A1
Abstract:
An arylamidine derivative represented by the general formula (1) (wherein X means optionally substituted lower alkylene or alkenylene; G1 means oxygen, sulfur, or imino; G2 means carbon or nitrogen; Ra means at least one member selected among hydrogen, halogeno, and optionally substituted alkyl, cycloalkyl, and alkoxy; R1 means optionally protected or substituted amidino; and R2 means substituted amino, substituted cyclic amino, etc.) or a salt of the derivative. The derivative or salt has excellent antifungal activity and is highly safe. It is hence useful as a fungicide with satisfactory behavior in the body.
Inventors:
HAYASHI KAZUYA (JP)
OJIMA KATSUJI (JP)
HORI KOZO (JP)
OKUJO HIROYUKI (JP)
MITSUYAMA JUNICHI (JP)
KUNITANI KAZUTO (JP)
TOHDO KEISUKE (JP)
OJIMA KATSUJI (JP)
HORI KOZO (JP)
OKUJO HIROYUKI (JP)
MITSUYAMA JUNICHI (JP)
KUNITANI KAZUTO (JP)
TOHDO KEISUKE (JP)
Application Number:
PCT/JP2003/002506
Publication Date:
September 12, 2003
Filing Date:
March 04, 2003
Export Citation:
Assignee:
TOYAMA CHEMICAL CO LTD (JP)
HAYASHI KAZUYA (JP)
OJIMA KATSUJI (JP)
HORI KOZO (JP)
OKUJO HIROYUKI (JP)
MITSUYAMA JUNICHI (JP)
KUNITANI KAZUTO (JP)
TOHDO KEISUKE (JP)
HAYASHI KAZUYA (JP)
OJIMA KATSUJI (JP)
HORI KOZO (JP)
OKUJO HIROYUKI (JP)
MITSUYAMA JUNICHI (JP)
KUNITANI KAZUTO (JP)
TOHDO KEISUKE (JP)
International Classes:
A61K31/138; A61K31/44; A61P31/10; C07C257/18; C07C259/18; C07C271/64; C07C323/62; C07D207/14; C07D211/22; C07D211/26; C07D211/58; C07D213/62; C07D213/78; C07D213/85; C07D241/04; C07D241/08; C07D243/08; C07D245/02; C07D261/12; C07D295/092; C07D295/13; C07D401/06; C07D413/06; (IPC1-7): C07C257/18; C07D241/08; A61K31/155; A61K31/197; A61K31/198; A61K31/495; A61K31/445; A61K31/551; A61P31/10
Foreign References:
| GB868552A | 1961-05-17 | |||
| EP1178038A1 | 2002-02-06 | |||
| EP0805149A1 | 1997-11-05 | |||
| GB868552A | 1961-05-17 |
Other References:
TIDWELL R.R. ET AL.: "Analogs of 1,5-bis(4-amidinophenoxy) pentane (pentamidine) in the treatment of experimental pneumocystis carinii pneumonia", JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, no. 4, 1990, pages 1252 - 1257, XP000644781
BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 7, 1997, pages 521 - 526
JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, 1990, pages 1252 - 1257
See also references of EP 1481966A4
BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 7, 1997, pages 521 - 526
JOURNAL OF MEDICINAL CHEMISTRY, vol. 33, 1990, pages 1252 - 1257
See also references of EP 1481966A4
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