Title:
NOVEL ARYLATED CAMPHENES, PROCESSES FOR THEIR PREPARATION AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2011/061744
Kind Code:
A3
Abstract:
The present invention relates to arylated camphenes, processes for their preparation and uses thereof for the manufacture of medicaments for the treatment of diseases, disorders or conditions associated with, or benefiting from stimulation of CB2 receptors.
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Inventors:
MECHOULAM RAPHAEL (IL)
MAGID LITAL (IL)
SHOHAMI ESTHER (IL)
BAB ITAI (IL)
MAGID LITAL (IL)
SHOHAMI ESTHER (IL)
BAB ITAI (IL)
Application Number:
PCT/IL2010/000970
Publication Date:
September 29, 2011
Filing Date:
November 18, 2010
Export Citation:
Assignee:
YISSUM RES DEV CO (IL)
MECHOULAM RAPHAEL (IL)
MAGID LITAL (IL)
SHOHAMI ESTHER (IL)
BAB ITAI (IL)
MECHOULAM RAPHAEL (IL)
MAGID LITAL (IL)
SHOHAMI ESTHER (IL)
BAB ITAI (IL)
International Classes:
C07C43/215; A61K31/09; A61K31/125; A61K31/192; A61K31/216; A61K31/352; A61P19/00; A61P25/00; A61P25/04; A61P25/28; C07C43/23; C07C49/753; C07C62/34; C07C69/757; C07D311/80
Domestic Patent References:
| WO2008154083A2 | 2008-12-18 |
Foreign References:
| US2537647A | 1951-01-09 |
Other References:
A. MAKRIYANNIS: "Bornyl- and Isobornyl-delta8-tetrahydrocannabinols: A Novel Class of Cannabinergic Ligands", J.MED.CHEM., no. 51, 1 October 2008 (2008-10-01), pages 6393 - 6399, XP002638927
DUCLOS R I ET AL: "Synthesis and characterization of 2-substituted bornane pharmacophores for novel cannabinergic ligands", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 49, no. 39, 22 September 2008 (2008-09-22), pages 5587 - 5589, XP023902273, ISSN: 0040-4039, [retrieved on 20080706], DOI: DOI:10.1016/J.TETLET.2008.07.029
BELA SZABO: "Pharmacology of Cannabinoid Receptors", BIOTREND REVIEWS, no. 2, 2008, pages 1 - 13, XP002638928
HANUS: "HU-308: A specific agonist for CB2, a peripheral cannabinoid receptor", PROC. NAT. ACAD. SC., vol. 96, no. 25, 7 December 1999 (1999-12-07), pages 14228 - 14233, XP002638929
DUCLOS R I ET AL: "Synthesis and characterization of 2-substituted bornane pharmacophores for novel cannabinergic ligands", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 49, no. 39, 22 September 2008 (2008-09-22), pages 5587 - 5589, XP023902273, ISSN: 0040-4039, [retrieved on 20080706], DOI: DOI:10.1016/J.TETLET.2008.07.029
BELA SZABO: "Pharmacology of Cannabinoid Receptors", BIOTREND REVIEWS, no. 2, 2008, pages 1 - 13, XP002638928
HANUS: "HU-308: A specific agonist for CB2, a peripheral cannabinoid receptor", PROC. NAT. ACAD. SC., vol. 96, no. 25, 7 December 1999 (1999-12-07), pages 14228 - 14233, XP002638929
Attorney, Agent or Firm:
REINHOLD COHN AND PARTNERS (61131 Tel Aviv, IL)
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