Title:
NOVEL ATISANE COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2002/088061
Kind Code:
A1
Abstract:
A novel compound which is highly effective in ameliorating the cellular disorders caused by radicals and in inhibiting the neurotoxicity induced by excitatory neurotransmitters such as glutamic acid. It is a compound represented by the following formula, a salt thereof, or a hydrate of either. (I) In the formula, Z means an optionally substituted, divalent, C2−3 organic group, etc., and R3 represents carboxyl, etc.
Inventors:
AKAIKE AKINORI (JP)
SUGIMOTO HACHIRO (JP)
NISHIZAWA YUKIO (JP)
YONAGA MASAHIRO (JP)
ASAKAWA NAOKI (JP)
ASAI NAOKI (JP)
MANO NARIYASU (JP)
TERAUCHI TARO (JP)
DOKO TAKASHI (JP)
SUGIMOTO HACHIRO (JP)
NISHIZAWA YUKIO (JP)
YONAGA MASAHIRO (JP)
ASAKAWA NAOKI (JP)
ASAI NAOKI (JP)
MANO NARIYASU (JP)
TERAUCHI TARO (JP)
DOKO TAKASHI (JP)
Application Number:
PCT/JP2002/004155
Publication Date:
November 07, 2002
Filing Date:
April 25, 2002
Export Citation:
Assignee:
EISAI CO LTD (JP)
AKAIKE AKINORI (JP)
SUGIMOTO HACHIRO (JP)
NISHIZAWA YUKIO (JP)
YONAGA MASAHIRO (JP)
ASAKAWA NAOKI (JP)
ASAI NAOKI (JP)
MANO NARIYASU (JP)
TERAUCHI TARO (JP)
DOKO TAKASHI (JP)
AKAIKE AKINORI (JP)
SUGIMOTO HACHIRO (JP)
NISHIZAWA YUKIO (JP)
YONAGA MASAHIRO (JP)
ASAKAWA NAOKI (JP)
ASAI NAOKI (JP)
MANO NARIYASU (JP)
TERAUCHI TARO (JP)
DOKO TAKASHI (JP)
International Classes:
A61P17/00; C07C43/13; C07C43/315; C07C47/36; C07C47/37; C07C47/46; C07C62/06; C07C62/14; C07C69/00; C07C229/46; C07C235/26; C07C247/12; C07C255/31; C07C271/22; C07C309/66; C07C309/73; C07C317/18; C07C317/24; C07C317/28; C07C317/44; C07C317/46; C07C317/48; C07C317/50; C07C323/13; C07C323/22; C07C323/26; C07C323/43; C07C323/53; C07C323/55; C07C323/58; C07C323/60; C07C327/32; (IPC1-7): C07C35/44; A61K31/047; A61K31/075; A61K31/095; A61K31/10; A61K31/11; A61K31/145; A61K31/16; A61K31/19; A61K31/195; A61K31/215; A61K31/255; A61K31/27; A61K31/275; A61K31/655; A61P17/00; A61P21/00; A61P25/00; A61P25/16; A61P25/28; A61P27/02; A61P27/16; A61P37/08; A61P39/02; A61P39/06; A61P43/00; C07C43/18; C07C43/196; C07C47/46; C07C47/47; C07C69/608; C07C69/757; C07C229/50; C07C235/26; C07C247/12; C07C255/31; C07C271/22; C07C309/66; C07C309/73; C07C317/18; C07C317/24; C07C317/28; C07C317/44; C07C317/46; C07C317/48; C07C323/13; C07C323/15; C07C323/22; C07C323/26; C07C323/43; C07C323/48; C07C323/53; C07C323/55; C07C323/58; C07C323/59; C07C323/60; C07C327/32
Other References:
NGASSOUM M.B. ET AL.: "Essential oil and headspace from hyptis suaveolens (L.) poit. Leaves and flowers from cameroon", JOURNAL OF ESSENTIAL OIL RESEARCH, vol. 11, no. 3, 1999, pages 283 - 288, XP002955660
FRAGA B.M. ET AL.: "A chemotaxonomical study of sideritis massoniana taxa", BIOCHEM. SYST. ECOL., vol. 23, no. 7/8, 1995, pages 835 - 842, XP002955661
DING Y. ET AL.: "Tetracyclic diterpenols from euphorbia sieboldiana", PHYTOCHEMISTRY, vol. 30, no. 7, 1991, pages 2413 - 2415, XP002955662
FRAGA B.M. ET AL.: "Diterpenes from sideritis ferrensis", PHYTOCHEMISTRY, vol. 30, no. 3, 1991, pages 913 - 915, XP002955663
ZDERO C. ET AL.: "Eudesmane derivatives and other constituents from apalochlamys spectabilis and cassinia species", PHYTOCHEMISTRY, vol. 29, no. 10, 1990, pages 3201 - 3206, XP002955664
MORAES M.P.L. ET AL.: "Diterpenes from the fruits of xylopia aromatica", PHYTOCHEMISTRY, vol. 27, no. 10, 1988, pages 3205 - 3208, XP002955665
GIESBRECHT A.M. ET AL.: "In vitro study of the antibiotic activity of diterpenes", BRAZ. J. MED. BIOL. RES., vol. 20, no. 6, 1987, pages 807 - 810, XP002955666
ST. PYREK J.: "Neutral diterpenoids of helianthus annuus", J. NAT. PROD., vol. 47, no. 5, 1984, pages 822 - 827, XP002955667
MCALEES A.J. ET AL.: "Ring C functionalised diperpenoids. Part V. Preparation and formolysis of (16S)-ent-12beta-p-tolylsulphonyloxykaurane and the (16S)-ent-13-p-tolylsulphonyloxyatisanes", J. CHEM. SOC., PERKIN TRANS. 1, no. 9, 1975, pages 861 - 869, XP002955668
CAMPBELL H.M. ET AL.: "Ring C functionalized diterpenoids. IV. Minor products from the cleavage of cyclopropane ring in methyl ent-trachyloban-19-oate with thallic acetate", CAN. J. CHEM., vol. 53, no. 1, 1975, pages 20 - 25, XP002955669
CARRASCAL M.I. ET AL.: "Estructura del isosideritol", AN. QUIM., vol. 73, no. 3, 1977, pages 442 - 444, XP002955670
BELL R.A. ET AL.: "Experiments directed toward the total synthesis of terpenes. IX. The total synthesis of (+/-)-hibaene and the oxygenation of some tetracyclic diterpenes", J. ORG. CHEM., vol. 31, no. 8, 1966, pages 2536 - 2542, XP002955671
See also references of EP 1382591A4
FRAGA B.M. ET AL.: "A chemotaxonomical study of sideritis massoniana taxa", BIOCHEM. SYST. ECOL., vol. 23, no. 7/8, 1995, pages 835 - 842, XP002955661
DING Y. ET AL.: "Tetracyclic diterpenols from euphorbia sieboldiana", PHYTOCHEMISTRY, vol. 30, no. 7, 1991, pages 2413 - 2415, XP002955662
FRAGA B.M. ET AL.: "Diterpenes from sideritis ferrensis", PHYTOCHEMISTRY, vol. 30, no. 3, 1991, pages 913 - 915, XP002955663
ZDERO C. ET AL.: "Eudesmane derivatives and other constituents from apalochlamys spectabilis and cassinia species", PHYTOCHEMISTRY, vol. 29, no. 10, 1990, pages 3201 - 3206, XP002955664
MORAES M.P.L. ET AL.: "Diterpenes from the fruits of xylopia aromatica", PHYTOCHEMISTRY, vol. 27, no. 10, 1988, pages 3205 - 3208, XP002955665
GIESBRECHT A.M. ET AL.: "In vitro study of the antibiotic activity of diterpenes", BRAZ. J. MED. BIOL. RES., vol. 20, no. 6, 1987, pages 807 - 810, XP002955666
ST. PYREK J.: "Neutral diterpenoids of helianthus annuus", J. NAT. PROD., vol. 47, no. 5, 1984, pages 822 - 827, XP002955667
MCALEES A.J. ET AL.: "Ring C functionalised diperpenoids. Part V. Preparation and formolysis of (16S)-ent-12beta-p-tolylsulphonyloxykaurane and the (16S)-ent-13-p-tolylsulphonyloxyatisanes", J. CHEM. SOC., PERKIN TRANS. 1, no. 9, 1975, pages 861 - 869, XP002955668
CAMPBELL H.M. ET AL.: "Ring C functionalized diterpenoids. IV. Minor products from the cleavage of cyclopropane ring in methyl ent-trachyloban-19-oate with thallic acetate", CAN. J. CHEM., vol. 53, no. 1, 1975, pages 20 - 25, XP002955669
CARRASCAL M.I. ET AL.: "Estructura del isosideritol", AN. QUIM., vol. 73, no. 3, 1977, pages 442 - 444, XP002955670
BELL R.A. ET AL.: "Experiments directed toward the total synthesis of terpenes. IX. The total synthesis of (+/-)-hibaene and the oxygenation of some tetracyclic diterpenes", J. ORG. CHEM., vol. 31, no. 8, 1966, pages 2536 - 2542, XP002955671
See also references of EP 1382591A4
Attorney, Agent or Firm:
Furuya, Kaoru (2-17-8 Nihonbashi-Hamach, Chuo-ku Tokyo, JP)
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