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Title:
NOVEL AZOMETHINE DIRECT DYES BEARING AT LEAST ONE CATIONIC CHARGE, COSMETIC COMPOSITION COMPRISING AT LEAST ONE SUCH DYE, IMPLEMENTATION PROCESS THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/109192
Kind Code:
A1
Abstract:
The present invention relates to novel cationic azomethine direct dyes of formula (I) and the leuco forms thereof of formula (II), and also to the use thereof for dyeing keratin fibres, in particular human keratin fibres such as the hair: (I) (II) in which formula (I) or (II) X1, X2, R1, R2, R3, R4, R5, R6, n and n' are as defined in the description. The compounds of formula (I) according to the invention can give powerful, chromatic and sparingly selective colourings with good colour build-up, which are resistant to the various attacking factors to which keratin fibres may be subjected, such as inclement weather, light, washing and perspiration.

Inventors:
BLAIS STÉPHANE (FR)
SABELLE STÉPHANE (FR)
FADLI AZIZ (FR)
Application Number:
PCT/EP2017/083112
Publication Date:
June 21, 2018
Filing Date:
December 15, 2017
Export Citation:
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Assignee:
OREAL (FR)
International Classes:
A61K8/40; C07D403/12; A61K8/49; C07C225/22; C07D207/14; C07D233/61; C07D403/04
Domestic Patent References:
WO1995015144A11995-06-08
WO1995001772A11995-01-19
WO1996015765A11996-05-30
WO1994008969A11994-04-28
WO1994008970A11994-04-28
Foreign References:
FR3006180A12014-12-05
FR2983856A12013-06-14
FR2946647A12010-12-17
FR2056799A51971-05-14
FR2047932A11971-03-19
FR2165965A11973-08-10
FR2262023A11975-09-19
GB1026978A1966-04-20
GB1153196A1969-05-29
FR2801308A12001-05-25
DE2359399A11975-06-12
JP2013169571A2013-09-02
JPH0563124A1993-03-12
EP0770375A11997-05-02
DE3843892A11990-06-28
DE4133957A11993-04-15
FR2733749A11996-11-08
DE19543988A11997-05-28
FR2886136A12006-12-01
EP0714954A21996-06-05
Attorney, Agent or Firm:
CASALONGA (FR)
Download PDF:
Claims:
CLAIMS

1. Compound chosen from those of formulae (I) and (II) below, organic or mineral acid or base addition salts thereof, tautomeric forms, optical isomers or geometrical isomers thereof and/or solvates thereof:

in which formula (I) or (II):

- n and n', which may be identical or different, represent an integer equal to 0, 1 , 2, 3 or 4; preferably, n and n' represent 0;

- Ri and R2, which may be identical or different, represent:

a halogen atom,

- a C1-C6 alkyl radical,

a (Ci-Ce)alkyl radical substituted with one or more radicals chosen from the following radicals: i) hydroxyl, ii) amino -IM H2, iii) (Ci-C6)alkylamino, and iv) di(Ci- C6)alkylamino,

a (Ci-C6)alkoxy radical, and

- a (Ci-Ce)alkoxy radical substituted with one or more radicals chosen from the following radicals: i) hydroxyl, ii) amino, iii) (Ci-C6)alkylamino, and iv) di(Ci- C6)alkylamino,

- Xi and X2, which may be identical or different, represent:

a hydrogen atom,

- a sulfonic radical -SO3H or sulfonate radical -SO3",

a carboxyl radical -CO2H , a carboxylate radical -COO",

a C1-C4 alkoxycarbonyl radical,

a carbamide radical -CO2N H2,

an aromatic or non-aromatic, 5- to 10-membered cationic heterocycle, which is optionally substituted, especially with one or more identical or different radicals chosen from C1-C4 alkyl and C1-C4 hydroxyalkyl;

an aromatic or non-aromatic, 5- to 6-membered non-cationic heterocycle, substituted with: o an ammonium radical -ISTRR'R" with R, R' and R", which may be identical or different, representing a (Ci-C4)alkyl group optionally substituted with one or more hydroxyl groups, such as methyl, ethyl, propyl or 2- hydroxyethyl, and/or

o an aromatic or non-aromatic, 5- to 10-membered cationic heterocycle, which is optionally substituted, especially with one or more identical or different radicals chosen from C1-C4 alkyl and C1-C4 hydroxyalkyl, and/or o a hydroxyl, amino, C1-C4 alkylamino, di(Ci-C4)alkylamino, C1-C4 alkoxy, C1-C4 alkyl or C1-C4 hydroxyalkyl radical;

an ammonium radical -ISTRR'R", with R, R' and R" which may be identical or different, representing a (Ci-C4)alkyl group optionally substituted with one or more hydroxyl groups, such as methyl, ethyl, propyl or 2-hydroxyethyl, and preferably R, R' and R", which may be identical or different, represent a C1-C4 alkyl group such as methyl; or

a radical -W-Rs, in which:

o W represents:

- an oxygen or sulfur atom,

- a divalent group -N(Rg)-; or

- a linear or branched, saturated or unsaturated, preferably saturated, divalent hydrocarbon-based chain, comprising from 1 to 14 carbon atoms, said hydrocarbon-based chain being:

optionally substituted with one or more radicals, which may be identical or different, chosen from the following radicals: i) hydroxyl, ii) C1-C4 alkoxy, iii) amino -IM H2, iv) mono- and/or (di)(Ci-C6)(alkyl)amino, v) ammoniums -ISTRR'R" with R, R' and R" as defined previously, vi) aromatic or non-aromatic, optionally substituted, 5- to 10-membered cationic heterocycles, preferably a 5- or 6-membered cationic heteroaryl optionally substituted with one or more (Ci-C4)alkyl groups, such as (Ci-C4)(alkyl)imidazolium, vii) aromatic or non-aromatic, 5- or 6-membered non-cationic heterocycles, substituted with one or more radicals, which may be identical or different, chosen from the following radicals: a) ammonium -ISTRR'R" with R, R' and R" as defined previously, b) aromatic or non-aromatic, 5- to 10-membered cationic heterocycle, optionally substituted especially with one or more identical or different radicals chosen from C1-C4 alkyl; preferably, the cationic heterocycle is a cationic heteroaryl optionally substituted with one or more (Ci-C4)alkyl groups, such as (Ci-C4)(alkyl)imidazolium, and c) a hydroxyl, amino, C1-C4 alkylamino, di(Ci-C4)alkylamino, C1-C4 alkoxy, C1-C4 alkyl or C1-C4 hydroxyalkyl radical;

and/or

optionally interrupted and/or optionally terminating with one or more divalent heteroatoms or groups, which may be identical or different, chosen from:

- -0-, -S-, -N(Rio)-, -S(O)-, -S(0)2- and -C(X)- with X representing an oxygen or sulfur atom or N-R10 and R10 representing a hydrogen atom or a (Ci-Ce)alkyl group, and

- combinations thereof;

preferably optionally interrupted and/or optionally terminating with: -0-, -NH-, -O-C(O)-, -C(0)-0-, -C(0)-N(H)-, -N(H)-C(0)-, -N(H)-C(0)-N(H)- , -0-C(0)-N(H)-, -N(H)-C(0)-0- or -N(H)-C(NH)-NH-;

Re and Rg, which may be identical or different, represent:

a hydrogen atom,

a linear or branched C1-C14, in particular Ci-Cs and preferably C1-C6 alkyl group, said alkyl group being:

- optionally interrupted with one or more heteroatoms or groups, which may be identical or different, such as -0-, -S-, -N(Rio)-, -S(O)-, -S(0)2- and -C(X)- with X and R10 as defined previously, or combinations thereof; and/or

- optionally substituted with one or more radicals, which may be identical or different, chosen from: i) hydroxyl, ii) C1-C4 alkoxy, iii) amino -IMH2, iv) mono- and/or (di)(Ci-C6)(alkyl)amino, v) ammoniums -ISTRR'R" with R, R' and R" as defined previously, vi) aromatic or non-aromatic, optionally substituted, 5- to 10-membered cationic heterocycles, preferably a 5- or 6-membered cationic heteroaryl optionally substituted with one or more (Ci-C4)alkyl groups, such as (Ci-C4)(alkyl)imidazolium, vii) aromatic or non-aromatic, 5- or 6-membered non-cationic heterocycles, substituted with one or more radicals, which may be identical or different, chosen from the following radicals: a) ammonium - ISTRR'R" with R, R' and R" as defined previously, b) aromatic or non- aromatic, 5- to 10-membered cationic heterocycle, optionally substituted especially with one or more identical or different radicals chosen from C1-C4 alkyl; preferably, the cationic heterocycle is a cationic heteroaryl optionally substituted with one or more (Ci-C4)alkyl groups, such as (Ci- C4)(alkyl)imidazolium, and c) a hydroxyl, amino, C1-C4 alkylamino di(Ci- C4)alkylamino, C1-C4 alkoxy, C1-C4 alkyl or C1-C4 hydroxyalkyl radical;

- R3 and R4, which may be identical or different, representing:

- a hydrogen atom,

- a (Ci-Ce)alkyl radical optionally substituted with one or more radicals chosen from i) hydroxyl, ii) (Ci-C4)alkoxy, iii) amino, iv) (Ci-C6)alkylamino and v) di(Ci- C6)alkylamino;

- R5 and R6, which may be identical or different, represent an atom or group chosen from:

- a hydrogen atom,

- a halogen atom,

- a C1-C6 alkyl radical,

- a (Ci-Ce)alkyl radical substituted with one or more radicals chosen from the following radicals: i) hydroxyl, ii) amino -IMH2, iii) (Ci-C6)alkylamino, and iv) di(Ci- C6)alkylamino,

- a (Ci-C6)alkoxy radical, and

- a (Ci-Ce)alkoxy radical substituted with one or more radicals chosen from the following radicals: i) hydroxyl, ii) amino, iii) (Ci-C6)alkylamino, and iv) di(Ci- C6)alkylamino,

it being understood that:

Xi and/or X2 comprise at least one permanent cationic charge, and

- the compound of formula (I) or (II) optionally comprises one or more anions An" and optionally one or more cations M+ to ensure the electrical neutrality of the molecule;

with:

An" denotes an anion, preferably chosen from bromide, chloride, methylsulfate and toluenesulfonate ions or a mixture of these ions;

M+ represents a cation, preferably chosen from sodium, potassium, magnesium, calcium and ammonium.

2. Compound of formula (I) or (II) according to the preceding claim, characterized in that R3 and R4 represent a hydrogen atom.

3. Compound of formula (I) or (II) according to either of the preceding claims, characterized in that R5 and R6 represent a hydrogen atom.

4. Compound of formula (I) or (II) according to either of the preceding claims, characterized in that n and n' represent an integer equal to 0. 5. Compound of formula (I) or (II) according to any one of the preceding claims, characterized in that Xi and X2, which may be identical or different, represent:

a radical -ORs;

a radical -SRs;

a radical -N RsRg;

- a linear or branched C1-C14, in particular Ci-Cs and preferably C1-C6 alkyl radical, said alkyl radical being:

o optionally interrupted with one or more heteroatoms or groups, which may be identical or different, chosen from -0-, -S-, -N(Ri0)-, -S(O)-, S(0)2, and -C(X)- with X representing an oxygen or sulfur atom or N-R10 with R10 as defined in Claim 1 , or combinations thereof preferably chosen from: -O-C(O)-, -C(0)-0-, -

C(0)-N(H)-, -N(H)-C(0)-, -N(H)-C(0)-N(H)-, -0-C(0)-N(H)-, -N(H)-C(0)-0-, - N(H)-C(NH)-NH-; and/or

o optionally substituted with one or more radicals, which may be identical or different, chosen from the following radicals: i) hydroxyl, ii) C1-C4 alkoxy, iii) amino -IM H2, iv) mono- and/or di(Ci-C6)alkylamino, v) ammoniums -ISTRR'R",

An" with R, R' and R" as defined in Claim 1 , vi) optionally substituted, aromatic or non-aromatic, 5- to 10-membered cationic heterocycles, preferably a 5- or 6- membered cationic heteroaryl optionally substituted with one or more (Ci- C4)alkyl groups, such as (Ci-C4)(alkyl)irmidazolium, and vii) aromatic or non- aromatic, 5- or 6-membered non-cationic heterocycles, substituted with one or more radicals, which may be identical or different, chosen from the following radicals:

ammoniums -ISTRR'R" with R, R' and R" as defined previously, and/or optionally substituted, aromatic or non-aromatic, 5- to 10-membered cationic heterocycle, preferably a cationic heteroaryl optionally substituted with one or more (Ci-C4)alkyl groups, such as (Ci- C4)(alkyl)imidazolium;

- a hydroxyl, amino, C1-C4 alkylamino, di(Ci-C4)alkylamino, C1-C4 alkoxy,

C1-C4 alkyl or C1-C4 hydroxyalkyl radical.

a linear or branched C1-C14, in particular Ci-Cs and preferably C1-C6 alkoxy radical, said alkoxy radical being:

o optionally interrupted with one or more heteroatoms or groups, which may be identical or different, chosen from -0-, -S-, -N(Rio)-, -S(O)-, -S(0)2- and -

C(X)- with X and R10 as defined previously, or combinations thereof preferably chosen from: -O-C(O)-, -C(0)-0-, -C(0)-N(H)-, -N(H)-C(0)-, -N(H)-C(0)-N(H)- , -0-C(0)-N(H)-, -N(H)-C(0)-0-, -N(H)-C(NH)-NH-; and/or

o optionally substituted with one or more radicals, which may be identical or different, chosen from the following radicals: i) hydroxyl, ii) C1-C4 alkoxy, iii) amino -IM H2, iv) mono- and/or di(Ci-C6)alkylamino, v) ammoniums -ISTRR'R" with R, R' and R" as defined previously, vi) optionally substituted, aromatic or non-aromatic, 5- to 10-membered cationic heterocycles, preferably a 5- or 6- membered cationic heteroaryl optionally substituted with one or more (Ci- C4)alkyl groups, such as (Ci-C4)(alkyl)imidazolium, and vii) aromatic or non- aromatic, 5- or 6-membered non-cationic heterocycles, substituted with one or more radicals, which may be identical or different, chosen from the following radicals:

ammoniums -ISTRR'R" with R, R' and R" as defined previously, and/or ■ optionally substituted, aromatic or non-aromatic, 5- to 10-membered cationic heterocycle, preferably a cationic heteroaryl optionally substituted with one or more (Ci-C4)alkyl groups, such as (Ci-C4)(alkyl)imidazolium;

a hydroxyl, amino, C1-C4 alkylamino, di(Ci-C4)alkylamino, C1-C4 alkoxy, Ci- C4 alkyl or C1-C4 hydroxyalkyl radical.

with

- Re and Rg, which may be identical or different, represent an atom or group chosen from:

a hydrogen atom,

a (Ci-Ci4)alkyl radical, o optionally interrupted with one or more heteroatoms or groups, which may be identical or different, chosen from -0-, -S-, -N(H)-, -N(Rio)- with Rio as defined previously, -S(O)-, S(0)2, and -C(X)- with X representing an oxygen or sulfur atom or N-R-io with Rio as defined previously, or combinations thereof preferably chosen from: -O-C(O)-, -C(0)-0-, -C(O)- N(H)-, -N(H)-C(0)-, -N(H)-C(0)-N(H)-, -0-C(0)-N(H)-, -N(H)-C(0)-0-, - N(H)-C(NH)-NH-; and/or

o optionally substituted with one or more radicals, which may be identical or different, chosen from the following radicals: i) hydroxyl, ii) C1-C4 alkoxy, iii) amino -IMH2, iv) mono- and/or di(Ci-C6)alkylamino, v) ammoniums - NTRR'R" with R, R' and R" as defined previously, vi) optionally substituted, aromatic or non-aromatic, 5- to 10-membered cationic heterocycles, preferably a 5- or 6-membered cationic heteroaryl optionally substituted with one or more (Ci-C4)alkyl groups, such as (Ci-C4)(alkyl)imidazolium, and vii) aromatic or non-aromatic, 5- or 6-membered non-cationic heterocycles, substituted with one or more radicals, which may be identical or different, chosen from the following radicals:

ammoniums -NTRR'R" with R, R' and R" as defined previously,

optionally substituted, aromatic or non-aromatic, 5- to 10-membered cationic heterocycle, preferably a cationic heteroaryl optionally substituted with one or more (Ci-C4)alkyl groups, such as (Ci- C4)(alkyl)imidazolium; and

a hydroxyl, amino, C1-C4 alkylamino, di(Ci-C4)alkylamino, C1-C4 alkoxy, C1-C4 alkyl or C1-C4 hydroxyalkyl radical.

6. Compound of formula (I) or (II) according to any one of the preceding claims, characterized in that:

Xi and X2, which may be identical or different, represent a radical radical -N-RsRg; in which Re and Rg, which may be identical or different, represent an atom or group chosen from:

a hydrogen atom,

a (Ci-Cs)alkyl radical,

o optionally interrupted with one or more heteroatoms or groups, which may be identical or different, chosen from -0-, -S-, -N(H)-, -N(Rio)- with R10 as defined previously, -S(O)-, S(0)2, and -C(X)- with X representing an oxygen or sulfur atom or N-R10 with R10 as defined previously, or combinations thereof preferably chosen from: -O-C(O)-, -C(0)-0-, -C(0)-N(H)-, -N(H)-C(0)-, -N(H)- C(0)-N(H)-, -0-C(0)-N(H)-, -N(H)-C(0)-0-, -N(H)-C(NH)-NH-; and/or o optionally substituted with one or more radicals, which may be identical or different, chosen from the following radicals: i) hydroxyl, ii) C1-C4 alkoxy, iii) amino -IM H2, iv) mono- and/or di(Ci-C4)alkylamino, v) ammoniums -ISTRR'R" with R, R' and R" as defined in claim 1 , vi) optionally substituted, aromatic or non-aromatic, 5- to 10-membered cationic heterocycles, preferably a 5- or 6- membered cationic heteroaryl optionally substituted with one or more (Ci- C4)alkyl groups, such as (Ci-C4)(alkyl)imidazolium, and vii) aromatic or non- aromatic, 5- or 6-membered non-cationic heterocycles, substituted with one or more radicals, which may be identical or different, chosen from the following radicals:

ammoniums -ISTRR'R" with R, R' and R" as defined previously, ■ optionally substituted, aromatic or non-aromatic, 5- to 6-membered cationic heterocycle, preferably a cationic heteroaryl optionally substituted with one or more (Ci-C4)alkyl groups, such as (Ci-C4)(alkyl)imidazolium; and

a hydroxyl, amino, C1-C4 alkylamino, di(Ci-C4)alkylamino, C1-C4 alkoxy, Ci- C4 alkyl or C1-C4 hydroxyalkyl radical.

- n and n' represent an integer equal to 0;

R3 and R4, which may be identical or different, represent a hydrogen atom, a (Ci- Ce)alkyl radical, or a (Ci-Ce)alkyl radical substituted with one or more radicals chosen from hydroxyl and/or C1-C4 alkoxy; preferentially R3 and R4 represent a hydrogen atom;

- R5 and R6 represent a hydrogen atom;

it being understood that:

Xi and/or X2 comprise at least one permanent cationic charge, and

the compound of formula (I) or (II) comprises one or more anions An" to ensure the electrical neutrality of the molecule;

- An" is an anion as defined previously, preferably chosen from bromide, chloride, methyl sulfate and toluene sulfonate ions or a mixture of these ions; more preferentially, An" is a halide and even more preferentially a chloride.

7. Compound of formula (I) or (II) according to any one of the preceding claims, characterized in that Xi and X2, which may be identical or different, represent a radical - ORs or a radical -N RsRg, in which Re and Rg, which may be identical or different, represent an atom or group chosen from:

a hydrogen atom,

a (Ci-Cs)alkyl radical,

o optionally interrupted with one or more heteroatoms or groups, which may be identical or different, chosen from -0-, -S-, -N(H)-, -N(Rio)- with Rio as defined previously, -S(O)-, S(0)2, and -C(X)- with X representing an oxygen or sulfur atom or N-R-io with Rio as defined previously, or combinations thereof preferably chosen from: -O-C(O)-, -C(0)-0-, -C(O)- N(H)-, -N(H)-C(0)-, -N(H)-C(0)-N(H)-, -0-C(0)-N(H)-, -N(H)-C(0)-0-, -

N(H)-C(NH)-NH-; and/or

o optionally substituted with one or more radicals, which may be identical or different, chosen from:

hydroxyl radicals;

■ aromatic or non-aromatic, 5- to 10-membered cationic heterocycles, said cationic heterocycles being optionally substituted, preferably an aromatic or non-aromatic, 5- or 6-membered cationic heterocycle, optionally substituted with one or more (Ci-C4)alkyl groups, such as imidazoliums, piperaziniums, pyrrolidiniums, morpholiniums and piperidiniums, preferably pyrrolidiniums and piperidiniums;

ammoniums -ISTRR'R", An" with R, R' and R" as defined previously, such as trimethyammonium; and

aromatic or non-aromatic, 5- or 6-membered non-cationic heterocycles, substituted with one or more radicals, which may be identical or different, chosen especially from ammonium radicals -ISTRR'R" with R, R' and R" as defined previously, and/or with an aromatic or non-aromatic, 5- to 10- membered cationic heterocycle, said cationic heterocycle being optionally substituted, in particular optionally substituted with one or more (Ci-C4)alkyl groups.

8. Compound of formula (I) or (II) according to any one of the preceding claims, characterized in that Xi and X2 are different, preferably represent a radical -N RsRg in which Re and Rg, which may be identical or different, represent an atom or group chosen from a (d-Cs)alkyl radical, optionally substituted with one or more radicals, which may be identical or different, chosen from the following radicals: i) hydroxyl, ii) ammoniums -ISTRR'R" with R, R' and R" as defined previously, iii) aromatic or non- aromatic, 5- to 10-membered cationic heterocycles, preferably a 5-membered cationic heteroaryl optionally substituted with one or more (Ci-C4)alkyl groups, such as (Ci- C4)(alkyl)imidazolium, and iv) non-aromatic, 5-membered non-cationic heterocycles, substituted with one radical, chosen from the following radicals:

ammoniums -ISTRR'R" with R, R' and R" as defined previously,

optionally substituted, aromatic or non-aromatic, 5- to 6-membered cationic heterocycle, preferably a cationic heteroaryl optionally substituted with one or more (Ci-C4)alkyl groups, such as (Ci-C4)(alkyl)imidazolium; and - n and n' represent an integer equal to 0;

it being understood that:

Xi and/or X2 comprise at least one permanent cationic charge, and

the compound of formula (I) or (II) comprises one or more anions An" to ensure the electrical neutrality of the molecule.

9. Compound of formula (I) or (II) according to any one of the preceding claims 1 to 7, characterized in that Xi and X2 are identical, preferably represent a radical -N RsRg in which Re and Rg, which may be identical or different, represent an atom or group chosen from a (Ci-Cs)alkyl radical, optionally substituted with one or more radicals, which may be identical or different, chosen from the following radicals: i) hydroxyl, ii) ammoniums -ISTRR'R" with R, R' and R" as defined previously, iii) aromatic or non- aromatic, 5- to 10-membered cationic heterocycles, preferably a 5-membered cationic heteroaryl optionally substituted with one or more (Ci-C4)alkyl groups, such as (Ci- C4)(alkyl)imidazolium, and iv) non-aromatic, 5-membered non-cationic heterocycles, substituted with one radical, chosen from the following radicals:

ammoniums -ISTRR'R" with R, R' and R" as defined previously,

optionally substituted, aromatic or non-aromatic, 5- to 6-membered cationic heterocycle, preferably a cationic heteroaryl optionally substituted with one or more (Ci-C4)alkyl groups, such as (Ci-C4)(alkyl)imidazolium; and - n and n' represent an integer equal to 0;

it being understood that:

Xi and/or X2 comprise at least one permanent cationic charge, and

the compound of formula (I) or (II) comprises one or more anions An" to ensure the electrical neutrality of the molecule.

10. Compound of formula (I) or (II) according to any one of the preceding claims, characterized in that said cationic heterocycle(s) are chosen from imidazoliums, piperaziniums, pyrrolidiniums, morpholiniums and piperidiniums; optionally substituted with one or more radicals, which may be identical or different, chosen from (hydroxy)(Ci- C4)alkyl radicals.

11. Compound of formula (I) or (II) according to any one of Claims 1 to 7, characterized in that said non-cationic heterocycle(s) are 5- or 6-membered and are preferably chosen from piperidines, piperazines, pyrrolidines, morpholines, thiazoles, imidazoles and pyridines, more preferentially chosen from piperidines, piperazines, pyrrolidines, morpholines and imidazoles, the 5- or 6-membered non-cationic heterocycles possibly being substituted especially with:

an ammonium radical -ISTRR'R", An- with R, R' and R", which may be identical or different, representing a (Ci-C4)alkyl group optionally substituted with one or more hydroxyl groups, such as methyl, ethyl, propyl or 2-hydroxyethyl, and, more preferentially, the radical -ISTRR'R" denotes a trimethylammonium radical, and/or

an aromatic or non-aromatic, 5- to 10-membered cationic heterocycle, which is optionally substituted, especially with one or more identical or different radicals chosen from (hydroxy)(Ci-C4)alkyl radicals;

preferably, said non-cationic heterocycle(s) are 5- or 6-membered and are pyrrolidines substituted with:

an ammonium radical -ISTRR'R" with R, R' and R" as defined previously, preferably a trimethylammonium radical, and/or

an aromatic or non-aromatic, 5- to 10-membered cationic heterocycle, which is optionally substituted with one or more (hydroxy)(Ci-C4)alkyl groups.

12. Compound of formula (I) or (II) according to any one of Claims 1 to 7, characterized in that said non-cationic heterocycle(s) are 5- or 6-membered and aromatic, preferably chosen from imidazoles, pyridines, pyrimidines, benzimidazoles, benzothiazoles, oxazoles, benzotriazoles, pyrazoles, thiazoles, triazoles and benzoxazoles; said 5- or 6-membered non-cationic heterocycles possibly being substituted especially with:

· an ammonium radical -ISTRR'R" with R, R' and R", which may be identical or different, representing a (Ci-C4)alkyl group optionally substituted with one or more hydroxyl groups, such as methyl, ethyl, propyl or 2-hydroxyethyl, and, more preferentially, the radical -ISTRR'R" denotes a trimethylammonium radical, and/or an aromatic or non-aromatic, 5- to 10-membered cationic heterocycle, which is optionally substituted, especially with one or more identical or different radicals chosen from (hydroxy)(Ci-C4)alkyl radicals.

13. Compound of formula (I) or (II) according to any one of the preceding claims, characterized in that it is chosen from compounds [I] to (13) and (1 ') to (13'), and also the geometrical or optical isomers thereof, the tautomers thereof, the organic or mineral

(13)

3,3'-{[4-({4-amino-6-oxo-3-[(4-{[3- (trimethylammonio)propyl]amino}phenyl)imino]cyc lohexa-1 ,4-dien-1 - yl}amino)phenyl]imino}bis(N,N,N-trimethylpropan- 1 -aminium) salt

with An" as defined in Claim 1 .

14. Cosmetic composition comprising one or more compounds of formula (I) and/or (II) as defined in any one of Claims 1 to 13; preferably, the compounds of formula (I) and of formula (II) are chosen from compounds (1 ) to (13) and compounds (1 ') to (13'), as described in Claim 1 1 ; preferentially, the compounds are chosen from compounds (1 ) to (4) and (T) to (4').

15. Composition according to the preceding claim, characterized in that it does not comprise any chemical oxidizing agent. 16. Composition according to Claim 14, comprising one or more compounds of formula (I) and/or (II), preferentially one or more compounds of formula (II), characterized in that it also comprises one or more chemical oxidizing agents, chosen in particular from hydrogen peroxide, urea peroxide, alkali metal bromates, persalts such as perborates and persulfates, peracids, and oxidase enzymes (with the possible cofactors thereof), among which mention may be made of peroxidases, 2-electron oxidoreductases such as uricases, and 4-electron oxygenases, for instance laccases, and preferably, the chemical oxidizing agent is hydrogen peroxide.

17. Process for dyeing keratin fibres, in particular human keratin fibres such as the hair, in one or more steps, comprising the following steps:

either the application to said keratin fibres of a composition as defined in Claim 14, 15 or 16;

or the sequential application to said keratin fibres, in a first step a), of a composition according to Claim 14, which especially comprises one or more compounds of formula (I) or (II) as defined in any one of Claims 1 to 13, and then, in a second step b), of an oxidizing composition, which comprises one or more chemical oxidizing agents as described in Claim 16;

it being understood that, between step a) and step b), said fibres may be rinsed, and/or washed and then optionally dried.

18. Process according to Claim 17 for dyeing keratin fibres, in particular human keratin fibres such as the hair, in one or more steps, in which a composition which comprises one or more compounds of formula (I) as defined in any one of Claims 1 to 13 is applied to said fibres, and the fibres are then optionally rinsed, and/or washed, and said fibres are dried or left to dry.

19. Process according to Claim 17, in which a cosmetic composition comprising one or more compounds of formula (II) as defined in any one of Claims 1 to 13 is applied to said fibres, and the fibres are then optionally rinsed, and/or washed, and said fibres are dried or left to dry.

which consists for the compounds (I):

a) in a first stage, in reacting one molar equivalent of a nitrobenzene compound (i) comprising in position 2 a nucleofugal group Nu and in position 5 a hydroxyl group protected with a group Prot, with one molar equivalent of aniline compound (ii); Nu representing a nucleofugal group, such as a halogen atom, for instance a chlorine atom, a methoxide, tosylate, mesylate or sulfonate group, and Prot representing a protecting group for a hydroxyl function, such as a benzyl, tetrahydropyran or trialkylsilyl group. Preferably, this reaction is performed i) in a polar protic solvent such as in water or a mixture of water/Ci- Cio alcohol such as ethanol or in a polar aprotic solvent such as in 1 -methyl-2- pyrrolidinone, acetone, acetonitrile, pyridine or Ν,Ν-dimethylformamide, ii) and/or in the presence of one or more mineral or organic basifying agents, as defined below, chosen in particular from diisopropylethylamine, triethylamine, sodium hydroxide, potassium hydroxide, a mineral carbonate such as potassium carbonate, or an acetate, iii) and/or at a temperature of between 0°C and 75°C, preferably at 75°C; and then

in a second stage, in maintaining the reaction medium under stirring for a time of between 5 minutes and 48 hours, more particularly between 30 minutes and 24 hours if the reaction is performed at room temperature; and then

the reaction product (iii) is optionally purified via a standard technique such as recrystallization, filtration or chromatography;

in a third stage, in performing a reduction reaction, and at the same time a reaction for the deprotection of the hydroxyl function according to a standard literature method, on compound (iii), preferably, the reduction of compound (iii) may be performed in the presence of hydrazine, of ammonium formate, or under a hydrogen atmosphere, and in the presence of a hydrogenation catalyst based especially on a metal, for example palladium, nickel or rhodium, the reduction preferentially being performed with palladium on charcoal (Pd/C) under a hydrogen atmosphere; preferentially, this reaction is performed in a solvent such as esters, in particular such as (Ci-Ce)alkyl acetates, in particular ethyl acetate, (Ci-Ce)alkanols (i.e. a compound of formula R-OH with R = (Ci-Ce)-alkyl) such as ethanol or methanol, and mixtures thereof; better still, the solvent is ethanol, methanol or a mixture of the two; to give compound (iv); advantageously, the reduction is performed at a temperature of between 20 and 25°C in the presence of a catalytic amount of the hydrogenation catalyst, better still based on palladium such as Pd/C, and at a hydrogen pressure of greater than or equal to 1 bar, especially between 1 and 5 bar; the amount of catalyst is advantageously less than 10 mol% relative to the molar amount of the compound of formula (iii) to be hydrogenated; and then

in a fourth stage, in reacting compound (iv) with one molar equivalent of aniline compound (v) to give compound (Γ). Compound (Γ) is a particular compound of formula (I) according to the invention, in which R3 and R4 represent a hydrogen atom. Preferably, this reaction is performed i) in a polar protic solvent such as in water or a mixture of water/Ci-Cio alcohol such as ethanol or in a polar aprotic solvent such as in 1 -methyl-2-pyrrolidinone, acetone, acetonitrile, pyridine or Ν,Ν-dimethylformamide, ii) and/or in the presence of one or more mineral or organic basifying agents, as defined below, chosen in particular from diisopropylethylamine, triethylamine, sodium hydroxide, potassium hydroxide, a mineral carbonate such as potassium carbonate, or an acetate, iii) and/or at a temperature of between room temperature, i.e. 25°C, and the reflux temperature of the solvent, preferably at room temperature; and then

f) in a fifth stage, in maintaining the reaction medium under stirring for a time of between 5 minutes and 48 hours, more particularly between 30 minutes and 24 hours; and then

g) the reaction product (Γ) is optionally purified via a standard technique such as recrystallization, filtration or chromatography;

h) according to another variant, compound (iv) is not purified, and reacts with one molar equivalent of aniline compound (v) under the same conditions as steps e) and f), to give the product (Γ), which is optionally purified via a standard technique such as recrystallization, filtration or chromatography;

i) compound (Γ) possibly being N-substituted with halogenated reagents R3-Hal and R4-Hal with Hal representing a halogen atom, preferably CI or I, preferably with heating at the reflux point of the solvent and in the presence of an alkaline agent, in particular in a polar aprotic solvent such as THF, to give compound (I) according to the invention after filtration, removal of the precipitate and optionally purification by chromatography or recrystallization;

it being understood that in the formulae (i), (ii), (iii), (iv), (v), (I) and (II), the radicals Xi , X2, Ri to R6, n and n' are as defined in any one of Claims 1 to 13.

21. Use of one or more compounds of formula (I) and/or (II) as defined according to any one of Claims 1 to 13, optionally in the presence of one or more chemical oxidizing agents as defined in Claim 16, for dyeing keratin fibres, in particular human keratin fibres such as the hair.

22. Device comprising one or more compartments comprising a first compartment containing one or more compounds of formula (I) and/or (II) as defined in any one of Claims 1 to 13, and a second compartment comprising one or more chemical oxidizing agents as defined in Claim 16.

Description:
Novel azomethine direct dyes bearing at least one cationic charge, cosmetic composition comprising at least one such dye, implementation process therefor and use thereof The present invention relates to a process for dyeing keratin fibres, in particular human keratin fibres such as the hair, in one or more steps, comprising the application to said keratin fibres of a composition comprising one or more compounds of formula (I) and/or the leuco forms thereof of formula (II), and also to the use of one or more compounds of formula (I) and/or (II) for dyeing keratin fibres, and to a device.

It is known practice to dye keratin fibres, and in particular the hair, with cosmetic compositions containing one or more direct dyes, according to a "direct dyeing" process.

The process conventionally used in direct dyeing consists in applying to keratin fibres one or more direct dyes, or colouring molecules, which have affinity for said fibres, leaving them to stand on the fibres, and then rinsing the fibres. The direct dyes used hitherto are generally nitrobenzene dyes, anthraquinone dyes, nitropyridine dyes, dyes of azo, xanthene, acridine or azine type or triarylmethane-based dyes.

However, the colourings that result therefrom are temporary or semi-permanent, since the nature of the interactions that bind the direct dyes to the keratin fibre and their desorption from the surface and/or the core of the fibre are responsible for their weak dyeing power and their limited fastness with respect to washing, inclement weather or perspiration.

These dyes also have the drawback of lacking stability towards light, on account of the poor resistance of the chromophore to photochemical attack, which has a tendency to lead to fading over time of the colouring of keratin fibres and/or changing of the colour.

In addition, although a wide range of colours is currently accessible, it generally proves necessary to combine three dyes of complementary colours - trichromatic principle - in order to obtain a natural chestnut-brown, dark chestnut-brown, brown or black shade (see, for example, WO 95/15144 and WO 95/01772). This tripartite combination does not, however, show good persistence with respect to repeated shampooing. It generally, or even systematically, induces an unaesthetic changing of the colour, which the consumer finds dissuasive.

There is thus a real need for direct dyes that can dye keratin fibres in an intense, chromatic manner with good build-up of the colour, which are stable towards light, and/or capable of giving colourings that are resistant to the various attacking factors to which the fibres may be subjected, such as inclement weather, washing and/or perspiration.

The Applicant has thus discovered, surprisingly, that azomethine direct dyes bearing at least one cationic charge of formula (I) and the leuco forms thereof of formula (II) as defined below, and also the tautomeric forms, optical isomers and geometrical isomers thereof, the addition salts thereof with an organic or mineral acid or base, and/or the solvates thereof, make it possible to achieve these aims.

One particular aim of the present invention is also to be able to dye light keratin fibres efficiently in chestnut-brown, dark chestnut-brown, brown or brown with a glint or even black, with a single type of dye of formula (I) or (II) as defined below.

One subject of the invention is thus an azomethine direct dye of formula (I), and also the tautomeric forms, optical isomers and geometrical isomers thereof, the addition salts thereof with an organic or mineral acid or base and/or the solvates thereof:

(I)

in which formula (I):

- n and n', which may be identical or different, represent an integer equal to 0, 1 , 2, 3 or 4; preferably, n and n' represent 0;

- Ri and R2, which may be identical or different, represent:

a halogen atom,

- a C1-C6 alkyl radical,

a (Ci-Ce)alkyl radical substituted with one or more radicals chosen from the following radicals: i) hydroxyl, ii) amino -IM H2, iii) (Ci-C6)alkylamino, and iv) di(Ci- C6)alkylamino,

a (Ci-C6)alkoxy radical, and

- a (Ci-Ce)alkoxy radical substituted with one or more radicals chosen from the following radicals: i) hydroxyl, ii) amino, iii) (Ci-C6)alkylamino, and iv) di(Ci- C6)alkylamino,

- Xi and X2, which may be identical or different, represent:

a hydrogen atom,

- a sulfonic radical -SO3H or sulfonate radical -SO3 " ,

a carboxyl radical -CO2H , a carboxylate radical -COO " ,

a C1-C4 alkoxycarbonyl radical,

a carbamide radical -CO2N H2, an aromatic or non-aromatic, 5- to 10-membered cationic heterocycle, which is optionally substituted, especially with one or more identical or different radicals chosen from C1-C4 alkyl and C1-C4 hydroxyalkyl;

an aromatic or non-aromatic, 5- to 6-membered non-cationic heterocycle, substituted with:

o an ammonium radical -ISTRR'R" with R, R' and R", which may be identical or different, representing a (Ci-C4)alkyl group optionally substituted with one or more hydroxyl groups, such as methyl, ethyl, propyl or 2- hydroxyethyl, and/or

o an aromatic or non-aromatic, 5- to 10-membered cationic heterocycle, which is optionally substituted, especially with one or more identical or different radicals chosen from C1-C4 alkyl and C1-C4 hydroxyalkyl, and/or o a hydroxyl, amino, C1-C4 alkylamino, di(Ci-C4)alkylamino, C1-C4 alkoxy, C1-C4 alkyl or C1-C4 hydroxyalkyl radical;

an ammonium radical -ISTRR'R", with R, R' and R" as defined previously, and preferably R, R' and R", which may be identical or different, represent a C1-C4 alkyl group such as methyl; or

a radical -W-Rs, in which:

o W represents:

- an oxygen or sulfur atom,

- a divalent group -N(Rg)-; or

- a linear or branched, saturated or unsaturated, preferably saturated, divalent hydrocarbon-based chain, comprising from 1 to 14 carbon atoms, said hydrocarbon-based chain being:

optionally substituted with one or more radicals, which may be identical or different, chosen from the following radicals: i) hydroxyl, ii) C1-C4 alkoxy, iii) amino -IM H2, iv) mono- and/or (di)(Ci-C6)(alkyl)amino, v) ammoniums -ISTRR'R" with R, R' and R" as defined previously, vi) aromatic or non-aromatic, optionally substituted, 5- to 10-membered cationic heterocycles, preferably a 5- or 6-membered cationic heteroaryl optionally substituted with one or more (Ci-C4)alkyl groups, such as (Ci-C4)(alkyl)imidazolium, vii) aromatic or non-aromatic, 5- or 6-membered non-cationic heterocycles, substituted with one or more radicals, which may be identical or different, chosen from the following radicals: a) ammonium -ISTRR'R" with R, R' and R" as defined previously, b) aromatic or non-aromatic, 5- to 10-membered cationic heterocycle, optionally substituted especially with one or more identical or different radicals chosen from C1-C4 alkyl; preferably, the cationic heterocycle is a cationic heteroaryl optionally substituted with one or more (Ci-C4)alkyl groups, such as (Ci-C4)(alkyl)imidazolium, and c) a hydroxyl, amino, C1-C4 alkylamino, di(Ci-C4)alkylamino, C1-C4 alkoxy, C1-C4 alkyl or C1-C4 hydroxyalkyl radical;

and/or

optionally interrupted and/or optionally terminating with one or more divalent heteroatoms or groups, which may be identical or different, chosen from:

- -0-, -S-, -N(Rio)-, -S(O)-, -S(0) 2 - and -C(X)- with X representing an oxygen or sulfur atom or N-R10 and R10 representing a hydrogen atom or a (Ci-Ce)alkyl group, and

- combinations thereof;

preferably optionally interrupted and/or optionally terminating with: -0-, -NH-, -O-C(O)-, -C(0)-0-, -C(0)-N(H)-, -N(H)-C(0)-, -N(H)-C(0)-N(H)- , -0-C(0)-N(H)-, -N(H)-C(0)-0- or -N(H)-C(NH)-NH-;

Re and R9, which may be identical or different, represent:

a hydrogen atom,

a linear or branched C1-C14, in particular Ci-Cs and preferably C1-C6 alkyl group, said alkyl group being:

- optionally interrupted with one or more heteroatoms or groups, which may be identical or different, such as -0-, -S-, -N(Rio)-, -S(O)-, -S(0)2- and -C(X)- with X and R10 as defined previously, or combinations thereof; and/or

- optionally substituted with one or more radicals, which may be identical or different, chosen from: i) hydroxyl, ii) C1-C4 alkoxy, iii) amino -IM H2, iv) mono- and/or (di)(Ci-C6)(alkyl)amino, v) ammoniums -ISTRR'R" with R, R' and R" as defined previously, and vi) aromatic or non-aromatic, optionally substituted, 5- to 10-membered cationic heterocycles, preferably a 5- or 6-membered cationic heteroaryl optionally substituted with one or more (Ci-C4)alkyl groups, such as (Ci-C4)(alkyl)imidazolium, vii) aromatic or non-aromatic, 5- or 6-membered non-cationic heterocycles, substituted with one or more radicals, which may be identical or different, chosen from the following radicals: a) ammonium - ISTRR'R" with R, R' and R" as defined previously, b) aromatic or non- aromatic, 5- to 10-membered cationic heterocycle, optionally substituted especially with one or more identical or different radicals chosen from C1-C4 alkyl; preferably, the cationic heterocycle is a cationic heteroaryl optionally substituted with one or more (Ci-C4)alkyl groups, such as (Ci- C4)(alkyl)imidazolium, and c) a hydroxyl, amino, C1-C4 alkylamino, di(Ci- C4)alkylamino, C1-C4 alkoxy, C1-C4 alkyl or C1-C4 hydroxyalkyl radical;

- R3 and R 4 , which may be identical or different, representing:

- a hydrogen atom,

- a (Ci-Ce)alkyl radical optionally substituted with one or more radicals chosen from i) hydroxyl, ii) (Ci-C4)alkoxy, iii) amino, iv) (Ci-C6)alkylamino and v) di(Ci- C6)alkylamino;

- R5 and R6, which may be identical or different, represent an atom or group chosen from:

- a hydrogen atom,

- a halogen atom,

- a C1-C6 alkyl radical,

- a (Ci-Ce)alkyl radical substituted with one or more radicals chosen from the following radicals: i) hydroxyl, ii) amino -IMH2, iii) (Ci-C6)alkylamino, and iv) di(Ci- C6)alkylamino,

- a (Ci-C6)alkoxy radical, and

- a (Ci-Ce)alkoxy radical substituted with one or more radicals chosen from the following radicals: i) hydroxyl, ii) amino, iii) (Ci-C6)alkylamino, and iv) di(Ci- C6)alkylamino,

it being understood that:

Xi and/or X2 comprise at least one permanent cationic charge, and

the compound of formula (I) optionally comprises one or more anions An " and optionally one or more cations M + to ensure the electrical neutrality of the molecule;

with:

An " denotes an anion, preferably chosen from bromide, chloride, methylsulfate and toluenesulfonate ions or a mixture of these ions;

M + represents a cation, preferably chosen from sodium, potassium, magnesium, calcium and ammonium.

By way of example: when only Xi (or, respectively, X2) bears a cationic charge and when none of the substituents bears an SO3 " or CO2 " radical, then the compounds of formula (I) comprise an anion An " such that the corresponding compound of formula (I) is globally neutral.

When only Xi and X2 bear a cationic charge and when none of the substituents bears an SO3 " or CO2 " radical, then the compounds of formula (I) comprise two singly charged anions An " such as two chloride anions or a doubly charged anion such as a sulfate, such that the corresponding compound of formula (I) is globally neutral.

When only Xi (or, respectively, X2) bears a cationic charge and when only one of the substituents bears an SO3 " or CO2 " radical, then the compounds of formula (I) do not comprise any anions An " such that the corresponding compound of formula (I) is globally neutral.

When only Xi (or, respectively, X2) bears a cationic charge and when two substituents bear an SO3 " or CO2 " radical, then the compounds of formula (I) do not comprise any anions An " but comprise a cation M + such that the corresponding compound of formula (I) is globally neutral.

Another subject of the present invention relates to the use of one or more azomethine direct dyes of formula (I), as defined previously, and/or of the leuco forms thereof (II) as defined below, optionally in the presence of one or more chemical oxidizing agents, for dyeing keratin fibres, in particular human keratin fibres such as the hair.

A subject of the present invention is also a cosmetic composition for dyeing keratin fibres, in particular human keratin fibres such as the hair, comprising one or more azomethine direct dyes of formula (I) and/or of the leuco forms thereof (II) as defined previously.

In particular, the invention also relates to the use of said cosmetic composition for dyeing keratin fibres, especially human keratin fibres such as the hair.

The invention also relates to a process for dyeing keratin fibres, in particular human keratin fibres such as the hair, in which the cosmetic composition as defined previously is applied to said fibres, said application optionally being followed by rinsing with water and/or washing, said process being followed by drying naturally or using a heating apparatus such as a drying hood or a hairdryer or a heating brush.

The invention relates more particularly to a process for dyeing and lightening keratin fibres, especially human keratin fibres such as the hair, in which (i) said cosmetic composition, free of oxidizing agent, and (ii) a cosmetic composition comprising one or more chemical oxidizing agents are applied to said fibres; compositions (i) and (ii) being applied to said keratin fibres sequentially or simultaneously for a time that is sufficient to obtain the desired lightening, after which the fibres are rinsed, optionally washed with shampoo and rinsed again, and the resulting fibres are dried or left to dry.

The azomethine direct dyes of formula (I) according to the invention can thus give colourings that are resistant to the various attacking factors to which keratin fibres may be subjected, such as inclement weather, light, washing and perspiration.

Furthermore, the direct dyes according to the invention can satisfactorily dye keratin fibres, especially producing powerful, chromatic and sparingly selective colourings, and/or with good colour build-up. The direct dyes according to the invention also have the advantage of being light- stable and can be used in the presence of an oxidizing agent, which facilitates their use in lightening direct dyeing cosmetic compositions based on oxidizing agents.

In other words, the direct dyes according to the present invention lead to persistent colourings and are compatible with cosmetic compositions intended for lightening keratin fibres.

Moreover, a subject of the invention is colourless or weakly coloured compounds of leuco type of formula (II) below, which correspond to the reduced form of the azomethine direct dyes of formula (I) according to the invention, organic or mineral acid or base salts thereof, tautomeric forms, optical isomers or geometrical isomers thereof, and/or solvates thereof:

(II)

in which formula (II) Xi, X2, Ri, R2, R3, R 4 , R5, R6, An " and M + n, and n', have the same meanings as those indicated previously in formula (I).

The compounds of leuco type according to the invention lead, in the presence of one or more chemical oxidizing agents or following exposure to atmospheric oxygen, to the azomethine direct dyes of formula (I).

It is known practice to use azomethine direct dyes for dyeing keratin fibres, but these dyes are not always satisfactory in terms of the dyeing property.

The novel azomethine direct dyes of formula (I) or the direct dyeing precursors (II) have the feature of being cationic and of having the advantage of producing powerful and sparingly chromatic colours. Furthermore, it is possible to obtain natural colours, especially intense black colours, on white keratin fibres using a single azomethine direct dye of formula (I) or a single direct dyeing precursor (II), without necessarily having to use a mixture of several direct dyes, or a mixture of several direct dyeing precursors, of complementary colours (trichromatic principle: see, for example, WO 95/15144 and WO 95/01772). The reason for this is that the mixture of direct dyes has the drawback of not being very stable with respect to light or washing, as a result of which unaesthetic changing of the colour is very often observed. Now, the dyes of the invention have good stability with respect to external agents such as light and washing once applied to the keratin fibres, and also good stability in oxidizing medium. Thus, the invention also relates to the use of one or more compounds of leuco type of formula (II) as precursors of the direct dyes of formula (I).

In particular, the invention relates to the use of one or more compounds of leuco type of formula (II) optionally in the presence of one or more chemical oxidizing agents, for dyeing keratin fibres, especially human keratin fibres such as the hair.

The compounds of leuco type of formula (II) used under oxidizing conditions thus have the advantage of giving colourings that are resistant to the various attacking factors to which keratin fibres may be subjected, such as inclement weather, washing, light or perspiration.

Moreover, the dyeing process using colourless or weakly coloured compounds of formula (II) followed by a step of revealing the colour in the presence of a chemical oxidizing agent makes it possible to produce clean dyeing, i.e. dyeing that produces very little or no staining of clothing or linen such as towels used during said process.

The invention also relates to a multi-compartment device or "kit" containing a first compartment comprising one or more compounds of formula (I) or of leuco type of formula (II) as defined previously, and a second compartment comprising one or more oxidizing agents.

Other characteristics, aspects, subjects and advantages of the present invention will emerge even more clearly on reading the description and the examples that follow.

For the purposes of the invention, unless otherwise indicated:

The term "anion or anionic counterion" means a cosmetically acceptable inorganic or organic anion derived from an organic or mineral acid salt associated with the cationic charge of the dye; more particularly, the anion is chosen from: i) halides such as chloride or bromide; ii) alkylsulfonates, including C1-C6 alkylsulfonates: Alk-S(0)20 " such as methylsulfonate or mesylate and ethylsulfonate; iii) arylsulfonates: Ar-S(0)20 " such as benzenesulfonate and toluenesulfonate or tosylate; iv) citrate; v) succinate; vi) tartrate; vii) lactate; xiii) alkyl sulfates: Alk-O- S(0)0 " such as methyl sulfate and ethyl sulfate; ix) aryl sulfates: Ar-0-S(0)0 " such as benzene sulfate and toluene sulfate; x) alkoxy sulfates: Alk-0-S(0)20 " such as methoxy sulfate and ethoxy sulfate; xi) aryloxy sulfates: Ar-0-S(0)20 " , xii) phosphates 0=Ρ(ΟΗ) 2 -0-, 0=P(0>OH 0=Ρ(0 " ) 3 , HO-[P(0)(0-)]w-P(0)(0-) 2 with w being an integer; xiii) acetate; xiv) triflate; xv) borates such as tetrafluoroborate, xvi) disulfate S(0)2C>2 " ; xvii) carbonate; and xviii) hydrogen carbonate;

more particularly, the cosmetically acceptable anions are chosen in particular from halides such as chloride, methosulfates; alkylsulfonates: Alk-S(0)20 " such as methylsulfonate or mesylate and ethylsulfonate; arylsulfonates: Ar-S(0)20 " such as benzenesulfonate and toluenesulfonate or tosylate; citrate; succinate; tartrate; lactate; alkyl sulfates: Alk-0-S(0)0 " such as methyl sulfate; aryl sulfates such as benzene sulfate and toluene sulfate; phosphate; acetate; triflate; and borates such as tetrafluoroborate; carbonate; and hydrogen carbonate.

As the anion derived from an organic or mineral acid salt ensures the electrical neutrality of the molecule, it is understood that when the anion comprises several anionic charges, then the same anion may serve for the electrical neutrality of several cationic groups in the same molecule or else may serve for the electrical neutrality of several molecules; for example, a dye of formula (I) which contains two cationic groups and no anionic radicals such as SO3 " or COO " may contain either two "singly charged" anions or a "doubly charged" anion such as S(0)202 " or

0=P(0>OH.

The term "cation or cationic counterion" means a cosmetically acceptable organic or inorganic cation or cationic group derived from an organic or mineral base salt associated with the anionic charge of the dye; more particularly, the cationic counterion is chosen from i) alkali metals such as Na + and K + , ii) alkaline-earth metals such as Ca ++ and Mg ++ , and iii) ammoniums such as R a RbR c RdN + with R a , Rb, Rc and Rd, which may be identical or different, representing a hydrogen atom or a hydroxyl or (Ci-Cs)alkyl group.

The term "alkyi' means a saturated, linear or branched hydrocarbon-based radical, preferably of C1-C6;

The term "hydroxyalkyi' means an alkyl group as defined previously substituted with one or more hydroxyl groups, preferably a (Ci-Ce)alkyl group substituted with a hydroxyl group, such as hydroxyethyl;

The term "(hydroxy)alkyr means an alkyl or hydroxyalkyl group as defined previously;

the term "alkoxy" means a group -O-alkyl with alkyl as defined previously; in particular, alkoxy denotes a methoxy or ethoxy group;

The term "cationic heterocycle" means a monocyclic or bicyclic, preferably monocyclic, 5- to 10-membered, preferably 5- to 8-membered heterocycle, at least one ring member of which is a heteroatom bearing a cationic charge such as N + , said heterocycle being saturated or unsaturated, aromatic or non-aromatic, and also possibly comprising at least one heteroatom, chosen from oxygen, nitrogen and/or sulfur atoms;

The aromatic cationic heterocycles (also known as cationic heteroaryls) are preferably chosen from imidazoliums, pyridiniums, pyrimidiniums, benzimidazoliums, benzothiazoliums, oxazoliums, benzotriazoliums, pyrazoliums, thiazoliums, triazoliums and benzoxazoliums;

The non-aromatic cationic heterocycles are in particular saturated cationic heterocycles, and are preferably chosen from piperaziniums, pyrrolidiniums, morpholiniums and piperidiniums;

each of the aromatic or non-aromatic, 5- to 10-membered cationic heterocycles possibly being substituted with one or more identical or different radicals chosen from (hydroxy)(Ci-C4)alkyl radicals;

the term "non-cationic heterocycle" means an aromatic or non-aromatic, 5- to 10- membered, preferably 5- to 6-membered, uncharged heterocycle, containing at least one heteroatom chosen from oxygen, nitrogen and/or sulfur atoms, preferably containing at least one nitrogen atom, and optionally substituted with:

a 5- to 10-membered cationic heterocycle as described above, preferably chosen from i) imidazolium, ii) pyridinium, iii) piperazinium, iv) pyrrolidinium, v) morpholinium, vi) pyrimidinium, vii) thiazolium, viii) benzimidazolium, ix) benzothiazolium, x) oxazolium, benzotriazolium, xi) pyrazolium, xii) triazolium, xiii) benzoxazolium, xiv) piperidinium; said cationic heterocycle being optionally substituted with one or more radicals, which may be identical or different, chosen from (hydroxy)(Ci-C4)alkyl radicals; and/or

a C1-C4 tri(hydroxy)alkylammonium radical, for instance trimethylammonium, triethylammonium, dimethylethylammonium, diethylmethylammonium, diisopropylmethylammonium, diethylpropylammonium, 2- hydroxyethyldiethylammonium, β-dihydroxyethylmethylammonium, β- trihydroxyethylammonium, dimethylhydroxyethylammonium, 2- hydroxyethyldimethylammonium or 2-hydroxyethylmethylethylammonium. the "ary or "heteroaryr or "heterocyclic" radicals may be substituted with at least one substituent borne by a carbon atom, chosen from:

a C1-C6 alkyl radical optionally substituted with one or more radicals chosen from the following radicals: hydroxyl, C1-C2 alkoxy, C2-C4 (poly)hydroxyalkoxy, acylamino, amino substituted with two identical or different C1-C4 alkyl radicals optionally bearing at least one hydroxyl group or the two radicals possibly forming, with the nitrogen atom to which they are attached, a saturated or unsaturated, optionally substituted, 5- to 7-membered and preferably 5- or 6-membered heterocycle optionally comprising another nitrogen or non-nitrogen heteroatom;

a halogen atom;

a hydroxyl group;

a C1-C2 alkoxy radical; a C2-C4 (poly)hydroxyalkoxy radical;

an amino radical;

an amino radical substituted with one or two identical or different C1-C6 alkyl radicals, optionally bearing at least:

i) a hydroxyl group,

ii) one amino group optionally substituted with one or two optionally substituted C1-C3 alkyl radicals, said alkyl radicals possibly forming with the nitrogen atom to which they are attached a saturated or unsaturated, optionally substituted 5- to 7-membered heterocycle, optionally comprising at least one other nitrogen or non-nitrogen heteroatom,

iii) a quaternary ammonium group -N + R'R"R"', An " for which R', R" and R"\ which may be identical or different, represent a hydrogen atom or a C1-C4 alkyl group and An " is as defined previously;

iv) or an optionally cationic 5- or 6-membered heteroaryl radical, preferentially imidazolium, optionally substituted with a (Ci-C4)alkyl radical, preferentially methyl;

an acylamino radical (-NR-C(O)-R') in which the radical R is a hydrogen atom or a C1-C4 alkyl radical optionally bearing at least one hydroxyl group and the radical R' is a C1-C2 alkyl radical;

a carbamoyl radical ((R)2N-C(0)-) in which the radicals R, which may be identical or different, represent a hydrogen atom or a C1-C4 alkyl radical optionally bearing at least one hydroxyl group;

an alkylsulfonylamino radical (R'-S(0)2-N(R)-) in which the radical R represents a hydrogen atom or a C1-C4 alkyl radical optionally bearing at least one hydroxyl group and the radical R' represents a C1-C4 alkyl radical or a phenyl radical; an aminosulfonyl radical ((R)2N-S(0)2-) in which the radicals R, which may be identical or different, represent a hydrogen atom or a C1-C4 alkyl radical optionally bearing at least one hydroxyl group;

a carboxylic radical in acid or salified (preferably with an alkali metal or a substituted or unsubstituted ammonium) form;

a cyano group;

a nitro or nitroso group;

a polyhaloalkyl group, preferentially trifluoromethyl;

the cyclic or heterocyclic part of a non-aromatic radical may be substituted with at least one substituent chosen from the following groups:

hydroxyl;

C1-C4 alkoxy or C2-C4 (poly)hydroxyalkoxy; • C1-C4 alkyl;

alkylcarbonylamino (R-C(O)-N(R')-) in which the radical R' is a hydrogen atom or a C1-C4 alkyl radical optionally bearing at least one hydroxyl group, and the radical R is a C1-C2 alkyl radical or an amino radical optionally substituted with one or two C1-C4 alkyl groups, which may be identical or different, optionally bearing at least one hydroxyl group, said alkyl radicals possibly forming, with the nitrogen atom to which they are attached, a saturated or unsaturated, optionally substituted 5- to 7-membered heterocycle optionally comprising at least one other nitrogen or non-nitrogen heteroatom;

· alkylcarbonyloxy (R-C(O)-O-) in which the radical R is a C1-C4 alkyl radical or an amino group optionally substituted with one or two identical or different Ci- C4 alkyl groups optionally bearing at least one hydroxyl group, said alkyl radicals possibly forming with the nitrogen atom to which they are attached a saturated or unsaturated, optionally substituted 5- to 7-membered heterocycle, optionally comprising at least one other nitrogen or non-nitrogen heteroatom;

alkoxycarbonyl (R-G-C(O)-) in which the radical R is a C1-C4 alkoxy radical, G is an oxygen atom or an amino group optionally substituted with a C1-C4 alkyl group optionally bearing at least one hydroxyl group, said alkyl radical possibly forming with the nitrogen atom to which they are attached a saturated or unsaturated, optionally substituted 5- to 7-membered heterocycle, optionally comprising at least one other nitrogen or non-nitrogen heteroatom;

a quaternary ammonium group -N + R'R"R"', An " for which R', R" and R"\ which may be identical or different, represent a hydrogen atom or a C1-C4

(hydroxy )alkyl group and An " is as defined previously;

a cyclic or heterocyclic radical, or a non-aromatic part of an aryl or heteroaryl radical, may also be substituted with one or more oxo groups. /. Azomethine direct dyes

According to a particular embodiment of the invention, the azomethine direct dye(s) are of formula (I) and the direct dyeing precursors of formula (II) such that, taken together or separately:

Xi and X2, which may be identical or different, represent:

- a radical -ORs;

a radical -SRs;

a radical -N RsRg; a linear or branched C1-C14, in particular Ci-Cs and preferably C1-C6 alkyl radical, said alkyl radical being:

o optionally interrupted with one or more heteroatoms or groups, which may be identical or different, chosen from -0-, -S-, -N(H)-, -N(Rio)- with R10 as defined previously, -S(O)-, S(0)2, and -C(X)- with X representing an oxygen or sulfur atom or N-R10 with R10 as defined previously, or combinations thereof preferably chosen from: -O-C(O)-, -C(0)-0-, -C(0)-N(H)-, -N(H)-C(0)-, -N(H)- C(0)-N(H)-, -0-C(0)-N(H)-, -N(H)-C(0)-0-, -N(H)-C(NH)-NH-; and/or o optionally substituted with one or more radicals, which may be identical or different, chosen from the following radicals: i) hydroxyl, ii) C1-C4 alkoxy, iii) amino -IM H2, iv) mono- and/or di(Ci-C6)alkylamino, v) ammoniums -ISTRR'R" with R, R' and R" as defined previously, vi) optionally substituted, aromatic or non-aromatic, 5- to 10-membered cationic heterocycles, preferably a 5- or 6- membered cationic heteroaryl optionally substituted with one or more (Ci- C 4 )alkyl groups, such as (Ci-C 4 )(alkyl)irmidazolium, and vii) aromatic or non- aromatic, 5- or 6-membered non-cationic heterocycles, substituted with one or more radicals, which may be identical or different, chosen from the following radicals:

ammoniums -ISTRR'R" with R, R' and R" as defined previously, and/or

optionally substituted, aromatic or non-aromatic, 5- to 10-membered cationic heterocycle, preferably a cationic heteroaryl optionally substituted with one or more (Ci-C 4 )alkyl groups, such as (Ci- C 4 )(alkyl)irmidazolium;

a hydroxyl, amino, C1-C4 alkylamino, di(Ci-C 4 )alkylamino, C1-C4 alkoxy, C1-C4 alkyl or C1-C4 hydroxyalkyl radical.

a linear or branched C1-C14, in particular Ci-Cs and preferably C1-C6 alkoxy radical, said alkoxy radical being:

o optionally interrupted with one or more heteroatoms or groups, which may be identical or different, chosen from -0-, -S-, -N(Rio)- with R10 as defined previously, -S(O)-, S(0)2, and -C(X)- with X representing an oxygen or sulfur atom or N-R10 with R10 as defined previously, or combinations thereof preferably chosen from: -O-C(O)-, -C(0)-0-, -C(0)-N(H)-, -N(H)-C(0)-, -N(H)- C(0)-N(H)-, -0-C(0)-N(H)-, -N(H)-C(0)-0-, -N(H)-C(NH)-NH-; and/or o optionally substituted with one or more radicals, which may be identical or different, chosen from the following radicals: i) hydroxyl, ii) C1-C4 alkoxy, iii) amino -IM H2, iv) mono- and/or di(Ci-C6)alkylamino, v) ammoniums -ISTRR'R" with R, R' and R" as defined previously, vi) optionally substituted, aromatic or non-aromatic, 5- to 10-membered cationic heterocycles, preferably a 5- or 6- membered cationic heteroaryl optionally substituted with one or more (Ci- C 4 )alkyl groups, such as (Ci-C 4 )(alkyl)irmidazolium, and vii) aromatic or non- aromatic, 5- or 6-membered non-cationic heterocycles, substituted with one or more radicals, which may be identical or different, chosen from the following radicals:

ammoniums -ISTRR'R" with R, R' and R" as defined previously, and/or

optionally substituted, aromatic or non-aromatic, 5- to 10-membered cationic heterocycle, preferably a cationic heteroaryl optionally substituted with one or more (Ci-C 4 )alkyl groups, such as (Ci-C 4 )(alkyl)irmidazolium; - a hydroxyl, amino, Ci-C 4 alkylamino, di(Ci-C 4 )alkylamino, C1-C4 alkoxy, Ci-

C 4 alkyl or C1-C4 hydroxyalkyl radical.

with

Re and Rg, which may be identical or different, represent an atom or group chosen from:

- a hydrogen atom,

a (Ci-Ci 4 )alkyl radical,

o optionally interrupted with one or more heteroatoms or groups, which may be identical or different, chosen from -0-, -S-, -N(Rio)- with Rio as defined previously, -S(O)-, S(0)2, and -C(X)- with X representing an oxygen or sulfur atom or N-R-io with Rio as defined previously, or combinations thereof preferably chosen from: -O-C(O)-, -C(0)-0-, -C(0)-N(H)-, -N(H)- C(O)-, -N(H)-C(0)-N(H)-, -0-C(0)-N(H)-, -N(H)-C(0)-0-, -N(H)-C(NH)-NH- ; and/or

o optionally substituted with one or more radicals, which may be identical or different, chosen from the following radicals: i) hydroxyl, ii) Ci-C 4 alkoxy, iii) amino -IMH2, iv) mono- and/or di(Ci-C6)alkylamino, v) ammoniums - ISTRR'R" with R, R' and R" as defined previously, vi) optionally substituted, aromatic or non-aromatic, 5- to 10-membered cationic heterocycles, preferably a 5- or 6-membered cationic heteroaryl optionally substituted with one or more (Ci-C 4 )alkyl groups, such as (Ci-C 4 )(alkyl)irmidazolium, and vii) aromatic or non-aromatic, 5- or 6-membered non-cationic heterocycles, substituted with one or more radicals, which may be identical or different, chosen from the following radicals:

ammoniums -ISTRR'R" with R, R' and R" as defined previously, ■ optionally substituted, aromatic or non-aromatic, 5- to 10-membered cationic heterocycle, preferably a cationic heteroaryl optionally substituted with one or more (Ci-C 4 )alkyl groups, such as (Ci- C 4 )(alkyl)irmidazolium; and a hydroxyl, amino, C1-C4 alkylamino, di(Ci-C4)alkylamino, C1-C4 alkoxy, C1-C4 alkyl or C1-C4 hydroxyalkyl radical.

Preferably, in formula (I), azomethine direct dyes according to the invention are such that, taken together or separately:

- Xi and X2, which may be identical or different, represent a radical -N-RsRg:

in which Re and Rg, which may be identical or different, represent an atom or group chosen from:

a hydrogen atom,

a (Ci-Cs)alkyl radical,

o optionally interrupted with one or more heteroatoms or groups, which may be identical or different, chosen from -0-, -S-, -N(H)-, -N(Rio)- with R10 as defined previously, -S(O)-, S(0)2, and -C(X)- with X representing an oxygen or sulfur atom or N-R10 with R10 as defined previously, or combinations thereof preferably chosen from: -O-C(O)-, -C(0)-0-, -C(0)-N(H)-, -N(H)-C(0)-, -N(H)- C(0)-N(H)-, -0-C(0)-N(H)-, -N(H)-C(0)-0-, -N(H)-C(NH)-NH-; and/or o optionally substituted with one or more radicals, which may be identical or different, chosen from the following radicals: i) hydroxyl, ii) C1-C4 alkoxy, iii) amino -IMH2, iv) mono- and/or di(Ci-C4)alkylamino, v) ammoniums -ISTRR'R" with R, R' and R" as defined previously, vi) optionally substituted, aromatic or non-aromatic, 5- to 10-membered cationic heterocycles, preferably a 5- or 6- membered cationic heteroaryl optionally substituted with one or more (Ci- C4)alkyl groups, such as (Ci-C4)(alkyl)imidazolium, and vii) aromatic or non- aromatic, 5- or 6-membered non-cationic heterocycles, substituted with one or more radicals, which may be identical or different, chosen from the following radicals:

ammoniums -ISTRR'R" with R, R' and R" as defined previously,

optionally substituted, aromatic or non-aromatic, 5- to 6-membered cationic heterocycle, preferably a cationic heteroaryl optionally substituted with one or more (Ci-C4)alkyl groups, such as (Ci-C4)(alkyl)imidazolium; and - a hydroxyl, amino, C1-C4 alkylamino, di(Ci-C4)alkylamino, C1-C4 alkoxy, Ci-

C4 alkyl or C1-C4 hydroxyalkyl radical,

n and n' represent an integer equal to 0;

R3 and R 4 , which may be identical or different, represent a hydrogen atom, a (Ci- Ce)alkyl radical, or a (Ci-Ce)alkyl radical substituted with one or more radicals chosen from hydroxyl and/or C1-C4 alkoxy; preferentially R3 and R4 represent a hydrogen atom;

R5 and R6 represent a hydrogen atom;

it being understood that: Xi and/or X2 comprise at least one permanent cationic charge, and

the compound of formula (I) comprises one or more anions An " to ensure the electrical neutrality of the molecule;

An " is an anion as defined previously, preferably chosen from bromide, chloride, methyl sulfate and toluene sulfonate ions or a mixture of these ions; more preferentially, An " is a halide and even more preferentially a chloride.

According to a particular embodiment of the invention, Xi and X2, which may be identical or different, represent a radical -ORs or a radical -N RsRg, in which Re and Rg, which may be identical or different, represent an atom or group chosen from:

a hydrogen atom,

a (Ci-Cs)alkyl radical,

o optionally interrupted with one or more heteroatoms or groups, which may be identical or different, chosen from -0-, -S-, -N(H)-, -N(Rio)- with R10 as defined previously, -S(O)-, S(0)2, and -C(X)- with X representing an oxygen or sulfur atom or N-R10 with R10 as defined previously, or combinations thereof preferably chosen from: -O-C(O)-, -C(0)-0-, -C(O)- N(H)-, -N(H)-C(0)-, -N(H)-C(0)-N(H)-, -0-C(0)-N(H)-, -N(H)-C(0)-0-, - N(H)-C(NH)-NH-; and/or

o optionally substituted with one or more radicals, which may be identical or different, chosen from:

hydroxyl radicals;

aromatic or non-aromatic, 5- to 10-membered cationic heterocycles, said cationic heterocycles being optionally substituted, preferably an aromatic or non-aromatic, 5- or 6-membered cationic heterocycle, optionally substituted with one or more (Ci-C4)alkyl groups, such as imidazoliums, piperaziniums, pyrrolidiniums, morpholiniums and piperidiniums, preferably pyrrolidiniums and piperidiniums;

ammoniums -ISTRR'R", An " with R, R' and R" as defined previously, such as trimethylammonium; and

aromatic or non-aromatic, 5- or 6-membered non-cationic heterocycles, substituted with one or more radicals, which may be identical or different, chosen especially from ammonium radicals -ISTRR'R" with R, R' and R" as defined previously, and/or with an aromatic or non-aromatic, 5- to 10- membered cationic heterocycle, said cationic heterocycle being optionally substituted, in particular optionally substituted with one or more (Ci-C4)alkyl groups. Preferably, the ammonium radicals -NTRR'R" described above are chosen from trimethylammonium, triethylammonium, dimethylethylammonium, diethylmethylammonium, diisopropylmethylammonium, diethylpropylammonium, 2- hydroxyethyldiethylammonium, /3-dihydroxyethylmethylammonium, β- trihydroxyethylammonium, dimethylhydroxyethylammonium, 2- hydroxyethyldimethylammonium and 2-hydroxyethylmethylethylammonium; preferentially, the ammonium radicals -NTRR'R" are chosen from trimethylammonium and 2- hydroxyethylmethylethylammonium; even more preferentially, the ammonium radicals NTRR'R" denote trimethylammonium.

According to a particular embodiment of the invention, the cationic heterocycles are 5- to 10-membered and aromatic and are preferably chosen from imidazoliums, pyridiniums, pyrimidiniums, benzimidazoliums, benzothiazoliums, oxazoliums, benzotriazoliums, pyrazoliums, thiazoliums, triazoliums and benzoxazoliums; each of said aromatic 5- to 10- membered cationic heterocycles being optionally substituted with one or more radicals, which may be identical or different, chosen from (hydroxy)(Ci-C4)alkyl radicals. According to this embodiment, the cationic heterocycles more preferentially denote imidazoliums optionally substituted with one or more identical or different (hydroxy)(Ci-C4)alkyl radicals.

According to another embodiment of the invention, the cationic heterocycles are 5- to 10-membered and non-aromatic and are preferably chosen from piperaziniums, pyrrolidiniums, morpholiniums, thiazoliums and piperidiniums; each of said non-aromatic 5- to 10-membered cationic heterocycles possibly being substituted with one or more radicals, which may be identical or different, chosen from (hydroxy)(Ci-C4)alkyl radicals. According to this embodiment, the cationic heterocycles more preferentially denote piperidiniums and pyrrolidiniums, and these non-aromatic cationic heterocycles are optionally substituted with one or more identical or different (hydroxy)(Ci-C4)alkyl radicals.

According to an advantageous variant of the invention, the cationic heterocycles are imidazoliums, which are optionally substituted, especially with one or more identical or different radicals chosen from (hydroxy)(Ci-C4)alkyl radicals, such as a methyl.

According to another preferential embodiment of the invention, the cationic heterocycles are chosen from imidazoliums, piperaziniums, pyrrolidiniums, morpholiniums and piperidiniums; optionally substituted with one or more radicals, which may be identical or different, chosen from (hydroxy)(Ci-C4)alkyl radicals.

According to a particular embodiment of the invention, the non-cationic heterocycles are 5- or 6-membered and are preferably chosen from piperidines, piperazines, pyrrolidines, morpholines, thiazoles, imidazoles and pyridines, more preferentially chosen from piperidines, piperazines, pyrrolidines, morpholines and imidazoles, the 5- or 6- membered non-cationic heterocycles possibly being substituted especially with: o an ammonium radical -ISTRR'R" with R, R' and R", which may be identical or different, representing a (Ci-C4)alkyl group optionally substituted with one or more hydroxyl groups, such as methyl, ethyl, propyl or 2-hydroxyethyl, and, more preferentially, the radical -ISTRR'R" denotes a trimethylammonium radical, and/or - an aromatic or non-aromatic, 5- to 10-membered cationic heterocycle, which is optionally substituted, especially with one or more identical or different radicals chosen from (hydroxy)(Ci-C4)alkyl radicals.

According to a particular embodiment of the invention, Xi and X2 are different, preferably represent a radical -N RsRg in which Re and Rg, which may be identical or different, represent an atom or group chosen from a (Ci-Cs)alkyl radical, optionally substituted with one or more radicals, which may be identical or different, chosen from the following radicals: i) hydroxyl, ii) ammoniums -ISTRR'R" with R, R' and R" as defined previously, iii) aromatic or non-aromatic, 5- to 10-membered cationic heterocycles, preferably a 5-membered cationic heteroaryl optionally substituted with one or more (Ci- C4)alkyl groups, such as (Ci-C4)(alkyl)imidazolium, and iv) non-aromatic, 5-membered non-cationic heterocycles, substituted with one radical, chosen from the following radicals:

ammoniums -ISTRR'R" with R, R' and R" as defined previously,

optionally substituted, aromatic or non-aromatic, 5- to 6-membered cationic heterocycle, preferably a cationic heteroaryl optionally substituted with one or more (Ci-C4)alkyl groups, such as (Ci-C4)(alkyl)imidazolium; and n and n' represent an integer equal to 0;

it being understood that:

Xi and/or X2 comprise at least one permanent cationic charge, and

- the compound of formula (I) comprises one or more anions An " to ensure the electrical neutrality of the molecule.

According to a particular embodiment of the invention, Xi and X2 are identical, preferably represent a radical -N RsRg in which Re and Rg, which may be identical or different, represent an atom or group chosen from a (d-Cs)alkyl radical, optionally substituted with one or more radicals, which may be identical or different, chosen from the following radicals: i) hydroxyl, ii) ammoniums -ISTRR'R" with R, R' and R" as defined previously, iii) aromatic or non-aromatic, 5- to 10-membered cationic heterocycles, preferably a 5-membered cationic heteroaryl optionally substituted with one or more (Ci- C4)alkyl groups, such as (Ci-C4)(alkyl)imidazolium, and iv) non-aromatic, 5-membered non-cationic heterocycles, substituted with one radical, chosen from the following radicals:

ammoniums -ISTRR'R" with R, R' and R" as defined previously, optionally substituted, aromatic or non-aromatic, 5- to 6-membered cationic heterocycle, preferably a cationic heteroaryl optionally substituted with one or more (Ci-C4)alkyl groups, such as (Ci-C4)(alkyl)imidazolium; and n and n' represent an integer equal to 0;

it being understood that:

Xi and/or X2 comprise at least one permanent cationic charge, and

the compound of formula (I) comprises one or more anions An " to ensure the electrical neutrality of the molecule. According to a particular embodiment of the invention, the non-cationic heterocycles are 5- or 6-membered and non-aromatic, preferably chosen from piperazines, pyrrolidines, morpholines and piperazines, and are more preferentially chosen from pyrrolidines and piperidines, and even more preferentially pyrrolidines, said 5- or 6- membered non-cationic heterocycles possibly being substituted especially with:

an ammonium radical -ISTRR'R" with R, R' and R", which may be identical or different, representing a (Ci-C4)alkyl group optionally substituted with one or more hydroxyl groups, such as methyl, ethyl, propyl or 2-hydroxyethyl, and, more preferentially, the radical -ISTRR'R" denotes a trimethylammonium radical, and/or an aromatic or non-aromatic, 5- to 10-membered cationic heterocycle, which is optionally substituted, especially with one or more identical or different radicals chosen from (hydroxy)(Ci-C4)alkyl radicals.

According to another embodiment of the invention, the non-cationic heterocycles are 5- or 6-membered and aromatic, preferably chosen from imidazoles, pyridines, pyrimidines, benzimidazoles, benzothiazoles, oxazoles, benzotriazoles, pyrazoles, thiazoles, triazoles and benzoxazoles; said 5- or 6-membered non-cationic heterocycles possibly being substituted especially with:

an ammonium radical -ISTRR'R" with R, R' and R", which may be identical or different, representing a (Ci-C4)alkyl group optionally substituted with one or more hydroxyl groups, such as methyl, ethyl, propyl or 2-hydroxyethyl, and, more preferentially, the radical -ISTRR'R" denotes a trimethylammonium radical, and/or an aromatic or non-aromatic, 5- to 10-membered cationic heterocycle, which is optionally substituted, especially with one or more identical or different radicals chosen from (hydroxy)(Ci-C4)alkyl radicals.

According to a particular embodiment of the invention, the non-cationic heterocycles contain at least one heteroatom chosen from O and N, and are substituted with one or more identical or different tri(hydroxy)(Ci-C4)alkylammonium radicals chosen from trimethylammonium, triethylammonium, dimethylethylammonium, diethylmethylammonium, diisopropylmethylammonium, diethylpropylammonium, 2- hydroxyethyldiethylammonium, β-dihydroxyethylmethylethylammonium, β- trihydroxyethylammonium, dimethylhydroxyethylammonium, 2- hydroxyethyldimethylammonium and 2-hydroxyethylmethylethylammonium; preferentially, the non-cationic heterocycles contain at least one heteroatom chosen from O and N, and are substituted with one or more identical or different tri(hydroxy)(Ci-C4)alkylammonium radicals chosen from trimethylammonium and 2-hydroxyethylmethylethylammonium, and even more preferentially one or more trimethylammonium radicals.

According to an advantageous variant of the invention, the non-cationic heterocycles are pyrrolidines substituted especially with:

one or more identical or different ammonium radicals -ISTRR'R" with R, R' and R" as defined previously, preferably a trimethylammonium radical, and/or an aromatic or non-aromatic, 5- to 10-membered cationic heterocycle, which is optionally substituted, especially with one or more (hydroxy)(Ci-C4)alkyl groups. The compounds of formula (I) may be used directly for dyeing the hair.

Preferably, the azomethine direct dyes of formula (I) according to the invention are chosen from compounds (1 ) to (13) below, and the geometrical or optical isomer forms thereof, the tautomers thereof, the organic or mineral acid or base salts thereof or the solvates thereof such as hydrates

with An " as defined previously. Preferably, the direct dyes of formula (I) according to the present invention are of structure (1), (2), {3} or (4), and also the geometrical or optical isomer forms thereof, the tautomers thereof, the organic or mineral acid or base salts thereof or the solvates thereof such as hydrates.

According to the invention, the compounds of formula (I) may optionally be salified with mineral acids, for instance HCI, HBr, H2SO4 or H3PO4, or organic acids, for instance acetic acid, lactic acid, tartaric acid, citric acid, succinic acid, benzenesulfonic acid, para- toluenesulfonic acid, formic acid or methanesulfonic acid.

According to the invention, the compounds of formula (I) may also be in the form of solvates, for example a hydrate or a solvate of a linear or branched alcohol, for instance ethanol or isopropanol.

The azomethine direct dyes of formula (I) may be obtained according to the procedure described below:

Another subject of the invention is a process for preparing compounds of formulae (I) and (II) as defined previously, according to the following schemes:

which consists for the compounds (I):

a) in a first stage, in reacting one molar equivalent of a nitrobenzene compound (i) comprising in position 2 a nucleofugal group Nu and in position 5 a hydroxyl group protected with a group Prot, with one molar equivalent of aniline compound (ii); Nu representing a nucleofugal group, such as a halogen atom, for instance a chlorine atom, a methoxide, tosylate, mesylate or sulfonate group, and Prot representing a protecting group for a hydroxyl function, such as a benzyl, tetrahydropyran or trialkylsilyl group. Preferably, this reaction is performed i) in a polar protic solvent such as in water or a mixture of water/Ci-

Cio alcohol such as ethanol or in a polar aprotic solvent such as in 1 -methyl-2- pyrrolidinone, acetone, acetonitrile, pyridine or N,N-dimethylformamide, ii) and/or in the presence of one or more mineral or organic basifying agents, as defined below, chosen in particular from diisopropylethylamine, triethylamine, sodium hydroxide, potassium hydroxide, a mineral carbonate such as potassium carbonate, or an acetate, iii) and/or at a temperature of between 0°C and 75°C, preferably at 75°C; and then

) in a second stage, in maintaining the reaction medium under stirring for a time of between 5 minutes and 48 hours, more particularly between 30 minutes and 24 hours if the reaction is performed at room temperature; and then

) the reaction product (iii) is optionally purified via a standard technique such as recrystallization, filtration or chromatography;

) in a third stage, in performing a reduction reaction, and at the same time a reaction for the deprotection of the hydroxyl function according to a standard literature method, on compound (iii). Preferably, the reduction of compound (iii) may be performed in the presence of hydrazine, of ammonium formate, or under a hydrogen atmosphere, and in the presence of a hydrogenation catalyst based especially on a metal, for example palladium, nickel or rhodium, the reduction preferentially being performed with palladium on charcoal (Pd/C) under a hydrogen atmosphere. Preferentially, this reaction is performed in a solvent such as esters, in particular such as (Ci-Ce)alkyl acetates, in particular ethyl acetate, (Ci-Ce)alkanols (i.e. a compound of formula R-OH with R = (Ci-Ce)-alkyl) such as ethanol or methanol, and mixtures thereof; better still, the solvent is ethanol, methanol or a mixture of the two; to give compound (iv). The conditions under which the reduction may be performed, such as the temperature, the amount of metal, the hydrogen pressure, the reaction time and the concentration, may be determined by a person skilled in the art.

Advantageously, the reduction is performed at a temperature of between 20 and 25°C in the presence of a catalytic amount of the hydrogenation catalyst, better still based on palladium such as Pd/C, and at a hydrogen pressure of greater than or equal to 1 bar, especially between 1 and 5 bar. The amount of catalyst is advantageously less than 10 mol% relative to the molar amount of the compound of formula (iii) to be hydrogenated, and then

) in a fourth stage, in reacting compound (iv) with one molar equivalent of aniline compound (v) to give compound (Γ). Compound (Γ) is a particular compound of formula (I) according to the invention, in which R3 and R 4 represent a hydrogen atom. Preferably, this reaction is performed i) in a polar protic solvent such as in water or a mixture of water/Ci-Cio alcohol such as ethanol or in a polar aprotic solvent such as in 1 -methyl-2-pyrrolidinone, acetone, acetonitrile, pyridine or Ν,Ν-dimethylformamide, ii) and/or in the presence of one or more mineral or organic basifying agents, as defined below, chosen in particular from diisopropylethylamine, triethylamine, sodium hydroxide, potassium hydroxide, a mineral carbonate such as potassium carbonate, or an acetate, iii) and/or at a temperature of between room temperature, i.e. 25°C, and the reflux temperature of the solvent, preferably at room temperature; and then

f) in a fifth stage, in maintaining the reaction medium under stirring for a time of between 5 minutes and 48 hours, more particularly between 30 minutes and 24 hours; and then

g) the reaction product (Γ) is optionally purified via a standard technique such as recrystallization, filtration or chromatography;

h) according to another variant, compound (iv) is not purified, and reacts with one molar equivalent of aniline compound (v) under the same conditions as steps e) and f), to give the product (Γ), which is optionally purified via a standard technique such as recrystallization, filtration or chromatography;

compound (Γ) possibly being N-substituted with halogenated reagents R3-Hal and R4-Hal with Hal representing a halogen atom, preferably CI or I, preferably with heating at the reflux point of the solvent and in the presence of an alkaline agent, in particular in a polar aprotic solvent such as THF, to give compound (I) according to the invention after filtration, removal of the precipitate and optionally purification by chromatography or recrystallization;

it being understood that in the formulae (i), (ii), (iii), (iv), (v), (I) and (II), the radicals Xi, X2, Ri to R6, n and n' are as defined previously.

Said process consisting for the compounds (II) in performing a reduction reaction on the compounds (I); synthetic approaches similar to this scheme are described in patent applications FR2056799, FR2047932, FR2165965 and FR2262023. The characterization is performed by NMR spectroscopy and/or mass spectrometry.

According to one variant of the invention, the compounds of formula (I) in which n and n' represent an integer equal to 0 and Xi represents a group -NRsRg, may be prepared according to the following preparation process:

which consists:

a) in a first stage, in reacting, naturally, one molar equivalent of the 1 -amino-5- hydroxybenzene compound (i') with one molar equivalent of the para- phenylenediamine compound (ϋ'). The pH of the solution is adjusted to an alkaline pH (pH greater than 7) with the aid of basifying agents as described previously, and optionally an excess of hydrogen peroxide is added to the solution. Preferably, this reaction is performed i) in a polar protic solvent such as in water or a mixture of water/Ci-Cio alcohol such as ethanol or in a polar aprotic solvent such as in 1 -methyl-2-pyrrolidinone, acetone, acetonitrile, pyridine or Ν,Ν-dimethylformamide, ii) and/or in the presence of one or more mineral or organic basifying agents, as defined below, chosen in particular from diisopropylethylamine, triethylamine, sodium hydroxide, potassium hydroxide, a mineral carbonate such as potassium carbonate, or an acetate, iii) and/or at a temperature of between 0°C and 75°C, preferably at 25°C; and then

b) in a second stage, in maintaining the reaction medium under stirring for a time of between 5 minutes and 48 hours, more particularly between 30 minutes and 24 hours if the reaction is performed at room temperature; and then

c) the compound of formula (iii') is optionally purified via a standard technique such as recrystallization, filtration or chromatography;

d) in a third stage, in performing a reaction between compound (iii') and one molar equivalent of aniline compound (iv'), under the same reaction conditions and with the same preferences as in step a); e) the compounds (I") corresponding to particular compounds of formula (I) in which n and n' represent an integer equal to 0 and Xi represents a group -N(Rs)-R9; f) said process consisting for the compounds (II"), according to this variant, in performing a reduction reaction on the compounds (I").

//. Cosmetic composition

The present invention also relates to a cosmetic composition, in particular for dyeing keratin fibres, more particularly human keratin fibres such as the hair, comprising one or more direct dyes of formula (I) as defined previously.

Preferably, the cosmetic composition comprises one or more azomethine direct dyes of formula (I) chosen from compounds (1 ) to (13) as defined previously, the geometrical or optical isomer forms thereof, the tautomers thereof, the organic or mineral acid or base salts thereof or the solvates thereof such as hydrates, and also mixtures thereof.

Even more preferentially, the cosmetic composition comprises one or more azomethine direct dyes of formula (I) chosen from compounds (1), (2), (3) or (4).

According to a particular embodiment, the cosmetic composition according to the invention also comprises one or more chemical oxidizing agents, chosen in particular from hydrogen peroxide, urea peroxide, alkali metal bromates, persalts such as perborates and persulfates, peracids, and oxidase enzymes (with the possible cofactors thereof), among which mention may be made of peroxidases, 2-electron oxidoreductases such as uricases, and 4-electron oxygenases, for instance laccases, and preferably, the chemical oxidizing agent is hydrogen peroxide.

The direct dye(s) as defined previously may be present in the cosmetic composition according to the invention in a content ranging from 0.001 % to 10% by weight, preferably in a content ranging from 0.005% to 6% by weight and preferentially in a content ranging from 0.1 % to 1 % relative to the total weight of the cosmetic composition.

The cosmetic composition according to the invention may also comprise one or more additional dyes chosen from oxidation dyes.

The oxidation dyes are generally chosen from one or more oxidation bases optionally combined with one or more couplers.

By way of example, the oxidation bases are chosen from para-phenylenediamines, bis(phenyl)alkylenediamines, para-aminophenols, ortho-aminophenols and heterocyclic bases, and the corresponding addition salts. Among the para-phenylenediamines that may be mentioned are, for example, para- phenylenediamine, para-toluenediamine, 2-chloro-para-phenylenediamine, 2,3-dimethyl- para-phenylenediamine, 2,6-dimethyl-para-phenylenediamine, 2,6-diethyl-para- phenylenediamine, 2,5-dimethyl-para-phenylenediamine, N,N-dimethyl-para- phenylenediamine, N,N-diethyl-para-phenylenediamine, N,N-dipropyl-para- phenylenediamine, 4-amino-N,N-diethyl-3-methylaniline, N,N-bis(p-hydroxyethyl)-para- phenylenediamine, 4-N,N-bis(p-hydroxyethyl)amino-2-methylaniline, 4-N,N-bis(3- hydroxyethyl)amino-2-chloroaniline, 2-p-hydroxyethyl-para-phenylenediamine, 2- methoxymethyl-para-phenylenediamine, 2-fluoro-para-phenylenediamine, 2-isopropyl- para-phenylenediamine, N-(p-hydroxypropyl)-para-phenylenediamine, 2-hydroxymethyl- para-phenylenediamine, N,N-dimethyl-3-methyl-para-phenylenediamine, N-ethyl-N-(p- hydroxyethyl)-para-phenylenediamine, N-(p,y-dihydroxypropyl)-para-phenylenediamine, N-(4'-aminophenyl)-para-phenylenediamine, N-phenyl-para-phenylenediamine, 2-β- hydroxyethyloxy-para-phenylenediamine, 2-p-acetylaminoethyloxy-para- phenylenediamine, N-(p-methoxyethyl)-para-phenylenediamine, 4- aminophenylpyrrolidine, 2-thienyl-para-phenylenediamine, 2-p-hydroxyethylamino-5- aminotoluene and 3-hydroxy-1 -(4'-aminophenyl)pyrrolidine, and the corresponding addition salts with an acid.

Among the para-phenylenediamines mentioned above, para-phenylenediamine, para- toluenediamine, 2-isopropyl-para-phenylenediamine, 2-p-hydroxyethyl-para- phenylenediamine, 2-p-hydroxyethyloxy-para-phenylenediamine, 2,6-dimethyl-para- phenylenediamine, 2,6-diethyl-para-phenylenediamine, 2,3-dimethyl-para- phenylenediamine, N,N-bis(p-hydroxyethyl)-para-phenylenediamine, 2-chloro-para- phenylenediamine and 2-p-acetylaminoethyloxy-para-phenylenediamine, and the corresponding addition salts with an acid, are particularly preferred.

Among the bis(phenyl)alkylenediamines that may be mentioned, for example, are N,N'-bis(p-hydroxyethyl)-N,N'-bis(4'-aminophenyl)-1 ,3-diaminopropanol, N,N'-bis(p- hydroxyethyl)-N,N'-bis(4'-aminophenyl)ethylenediamine, N,N'-bis(4- aminophenyl)tetramethylenediamine, N,N'-bis(p-hydroxyethyl)-N,N'-bis(4- aminophenyl)tetramethylenediamine, N,N'-bis(4- methylaminophenyl)tetramethylenediamine, N,N'-bis(ethyl)-N,N'-bis(4'-amino-3'- methylphenyl)ethylenediamine and 1 ,8-bis(2,5-diaminophenoxy)-3,6-dioxaoctane, and the corresponding addition salts.

Among the para-aminophenols that are mentioned are, for example, para- aminophenol, 4-amino-3-methylphenol, 4-amino-3-fluorophenol, 4-amino-3-chlorophenol, 4-amino-3-hydroxymethylphenol, 4-amino-2-methylphenol, 4-amino-2- hydroxymethylphenol, 4-amino-2-methoxymethylphenol, 4-amino-2-aminomethylphenol, 4-amino-2-(p-hydroxyethyl-aminomethyl)phenol and 4-amino-2-fluorophenol, and the corresponding addition salts with an acid. Among the ortho-aminophenols that may be mentioned, for example, are 2- aminophenol, 2-amino-5-methylphenol, 2-amino-6-methylphenol and 5-acetamido-2- aminophenol, and the corresponding addition salts.

Among the heterocyclic bases that may be mentioned, for example, are pyridine, pyrimidine and pyrazole derivatives.

Among the pyridine derivatives that may be mentioned are the compounds described, for example, in patents GB 1 026 978 and GB 1 153 196, for example 2,5- diaminopyridine, 2-(4-methoxyphenyl)amino-3-aminopyridine and 3,4-diaminopyridine, and the corresponding addition salts.

Other pyridine oxidation bases that are useful in the present invention are the 3- aminopyrazolo[1 ,5-a]pyridine oxidation bases or the corresponding addition salts described, for example, in patent application FR 2 801 308. Examples that may be mentioned include pyrazolo[1 ,5-a]pyrid-3-ylamine, 2-acetylaminopyrazolo[1 ,5-a]pyrid-3- ylamine, 2-(morpholin-4-yl)pyrazolo[1 ,5-a]pyrid-3-ylamine, 3-aminopyrazolo[1 ,5- a]pyridine-2-carboxylic acid, 2-methoxypyrazolo[1 ,5-a]pyrid-3-ylamine, (3- aminopyrazolo[1 ,5-a]pyrid-7-yl)methanol, 2-(3-aminopyrazolo[1 ,5-a]pyrid-5-yl)ethanol, 2- (3-aminopyrazolo[1 ,5-a]pyrid-7-yl)ethanol, (3-aminopyrazolo[1 ,5-a]pyrid-2-yl)methanol, 3,6-diaminopyrazolo[1 ,5-a]pyridine, 3,4-diaminopyrazolo[1 ,5-a]pyridine, pyrazolo[1 ,5- a]pyridine-3,7-diamine, 7-(morpholin-4-yl)pyrazolo[1 ,5-a]pyrid-3-ylamine, pyrazolo[1 ,5- a]pyridine-3,5-diamine, 5-(morpholin-4-yl)pyrazolo[1 ,5-a]pyrid-3-ylamine, 2-[(3- aminopyrazolo[1 ,5-a]pyrid-5-yl)(2-hydroxyethyl)amino]ethanol, 2-[(3-aminopyrazolo[1 ,5- a]pyrid-7-yl)(2-hydroxyethyl)amino]ethanol, 3-aminopyrazolo[1 ,5-a]pyridin-5-ol, 3- aminopyrazolo[1 ,5-a]pyridin-4-ol, 3-aminopyrazolo[1 ,5-a]pyridin-6-ol, 3- aminopyrazolo[1 ,5-a]pyridin-7-ol, 2-3-hydroxyethoxy-3-aminopyrazolo[1 ,5-a]pyridine and 2-(4-dimethylpiperazinium-1 -yl)-3-aminopyrazolo[1 ,5-a]pyridine, and the corresponding addition salts.

More particularly, the oxidation bases that are useful in the present invention are chosen from 3-aminopyrazolo[1 ,5-a]pyridines and are preferably substituted on carbon atom 2 with:

a) a (di)(Ci-C6)(alkyl)amino group, said alkyl group possibly being substituted with at least one hydroxyl, amino or imidazolium group;

b) an optionally cationic 5- to 7-membered heterocycloalkyl group comprising from 1 to 3 heteroatoms, optionally substituted with one or more (Ci-Ce)alkyl groups such as a di(Ci-C4)alkylpiperazinium group; or

c) a (Ci-C6)alkoxy group optionally substituted with one or more hydroxyl groups, such as a β-hydroxyalkoxy group, and the corresponding addition salts.

Among the pyrimidine derivatives that may be mentioned are the compounds described, for example, in patents DE 2359399; JP 88-169571 ; JP 05-63124; EP 0770375 or patent application WO 96/15765, such as 2,4,5,6-tetraaminopyrimidine, 4- hydroxy-2,5,6-triaminopyrimidine, 2-hydroxy-4,5,6-triaminopyrimidine, 2,4-dihydroxy-5,6- diaminopyrimidine, 2,5,6-triaminopyrimidine and the addition salts thereof and the tautomeric forms thereof, when a tautomeric equilibrium exists.

Among the pyrazole derivatives that may be mentioned are the compounds described in patents DE 3843892 and DE 4133957 and patent applications WO 94/08969, WO 94/08970, FR-A-2 733 749 and DE 195 43 988, for instance 4,5-diamino-1 - methylpyrazole, 4,5-diamino-1 -(p-hydroxyethyl)pyrazole, 3,4-diaminopyrazole, 4,5- diamino-1 -(4'-chlorobenzyl)pyrazole, 4,5-diamino-1 ,3-dimethylpyrazole, 4,5-diamino-3- methyl-1 -phenylpyrazole, 4,5-diamino-1 -methyl-3-phenylpyrazole, 4-amino-1 ,3-dimethyl- 5-hydrazinopyrazole, 1 -benzyl-4,5-diamino-3-methylpyrazole, 4,5-diamino-3-ie f-butyl-1 - methylpyrazole, 4,5-diamino-1 -ie f-butyl-3-methylpyrazole, 4,5-diamino-1 -(β- hydroxyethyl)-3-methylpyrazole, 4,5-diamino-1 -ethyl-3-methylpyrazole, 4,5-diamino-1 - ethyl-3-(4'-methoxyphenyl)pyrazole, 4,5-diamino-1 -ethyl-3-hydroxymethylpyrazole, 4,5- diamino-3-hydroxymethyl-1 -methylpyrazole, 4,5-diamino-3-hydroxymethyl-1 - isopropylpyrazole, 4,5-diamino-3-methyl-1 -isopropylpyrazole, 4-amino-5-(2'- aminoethyl)amino-1 ,3-dimethylpyrazole, 3,4,5-triaminopyrazole, 1 -methyl-3,4,5- triaminopyrazole, 3,5-diamino-1 -methyl-4-methylaminopyrazole and 3,5-diamino-4-(p- hydroxyethyl)amino-1 -methylpyrazole, and the corresponding addition salts. Use may also be made of 4,5-diamino-1 -(p-methoxyethyl)pyrazole.

A 4,5-diaminopyrazole will preferably be used and even more preferentially 4,5- diamino-1 -(p-hydroxyethyl)pyrazole and/or a corresponding salt.

The pyrazole derivatives that may also be mentioned include diamino-N,N- dihydropyrazolopyrazolones and in particular those described in patent application FR-A- 2 886 136, such as the following compounds and the corresponding addition salts: 2,3- diamino-6,7-dihydro-1 H,5H-pyrazolo[1 ,2-a]pyrazol-1 -one, 2-amino-3-ethylamino-6,7- dihydro-1 H,5H-pyrazolo[1 ,2-a]pyrazol-1 -one, 2-amino-3-isopropylamino-6,7-dihydro- 1 H,5H-pyrazolo[1 ,2-a]pyrazol-1 -one, 2-amino-3-(pyrrolidin-1 -yl)-6,7-dihydro-1 H,5H- pyrazolo[1 ,2-a]pyrazol-1 -one, 4,5-diamino-1 ,2-dimethyl-1 ,2-dihydropyrazol-3-one, 4,5- diamino-1 ,2-diethyl-1 ,2-dihydropyrazol-3-one, 4,5-diamino-1 ,2-bis(2-hydroxyethyl)-1 ,2- dihydropyrazol-3-one, 2-amino-3-(2-hydroxyethyl)amino-6,7-dihydro-1 H,5H-pyrazolo[1 ,2- a]pyrazol-1 -one, 2-amino-3-dimethylamino-6,7-dihydro-1 H,5H-pyrazolo[1 ,2-a]pyrazol-1 - one, 2,3-diamino-5,6,7,8-tetrahydro-1 H,6H-pyridazino[1 ,2-a]pyrazol-1 -one, 4-amino-1 ,2- diethyl-5-(pyrrolidin-1 -yl)-1 ,2-dihydropyrazol-3-one, 4-amino-5-(3-dimethylaminopyrrolidin- 1 -yl)-1 ,2-diethyl-1 ,2-dihydropyrazol-3-one and 2,3-diamino-6-hydroxy-6,7-dihydro-1 H,5H- pyrazolo[1 ,2-a]pyrazol-1 -one.

Use will preferably be made of 2,3-diamino-6,7-dihydro-1 H,5H-pyrazolo[1 ,2-a]pyrazol- 1 -one and/or a corresponding salt. Heterocyclic bases that will preferably be used include 4,5-diamino-1 -(p- hydroxyethyl)pyrazole and/or 2,3-diamino-6,7-dihydro-1 H,5H-pyrazolo[1 ,2-a]pyrazol-1 - one and/or a corresponding salt.

The composition according to the invention may optionally comprise one or more coupling agents advantageously chosen from those conventionally used in the dyeing of keratin fibres.

Among these coupling agents, mention may be made in particular of meta- phenylenediamines, meta-aminophenols, meta-diphenols, naphthalene-based coupling agents and heterocyclic coupling agents, and also the corresponding addition salts.

Mention may be made, for example, of 1 ,3-dihydroxybenzene, 1 ,3-dihydroxy-2- methylbenzene, 4-chloro-1 ,3-dihydroxybenzene, 2,4-diamino-1 -(3- hydroxyethyloxy)benzene, 2-amino-4-(3-hydroxyethylamino)-1 -methoxybenzene, 1 ,3- diaminobenzene, 1 ,3-bis(2,4-diaminophenoxy)propane, 3-ureidoaniline, 3-ureido-1 - dimethylaminobenzene, sesamol, 1 -3-hydroxyethylamino-3,4-methylenedioxybenzene, a- naphthol, 2-methyl-1 -naphthol, 6-hydroxyindole, 4-hydroxyindole, 4-hydroxy-N- methylindole, 2-amino-3-hydroxypyridine, 6-hydroxybenzomorpholine, 3,5-diamino-2,6- dimethoxypyridine, 1 -N-(3-hydroxyethyl)amino-3,4-methylenedioxybenzene, 2,6-bis(3- hydroxyethylamino)toluene, 6-hydroxyindoline, 2,6-dihydroxy-4-methylpyridine, 1 -H-3- methylpyrazol-5-one, 1 -phenyl-3-methylpyrazol-5-one, 2,6-dimethylpyrazolo[1 ,5-b]-1 ,2,4- triazole, 2,6-dimethyl[3,2-c]-1 ,2,4-triazole and 6-methylpyrazolo[1 ,5-a]benzimidazole, 2- methyl-5-aminophenol, 5-N-^-hydroxyethyl)amino-2-methylphenol, 3-aminophenol and 3-amino-2-chloro-6-methylphenol, the corresponding addition salts with an acid and the corresponding mixtures.

In general, the addition salts of oxidation bases and couplers that may be used in the context of the invention are chosen in particular from the addition salts with an acid such as the hydrochlorides, hydrobromides, sulfates, citrates, succinates, tartrates, lactates, tosylates, benzenesulfonates, phosphates and acetates.

The oxidation base(s) each advantageously represent from 0.001 % to 10% by weight, and preferably from 0.005% to 5% by weight relative to the total weight of the composition and of the ready-to-use composition.

The coupler(s), if it (they) are present, each advantageously represents from 0.001 % to 10% by weight, and preferably from 0.005% to 5% by weight relative to the total weight of the composition and of the ready-to-use composition.

The composition according to the invention may optionally comprise b) one or more additional synthetic or natural direct dyes, other than the compounds of formula (I) and/or (II), chosen from cationic, anionic and nonionic species, preferably cationic or nonionic species, either as sole dyes or in addition to the additional oxidation dye(s). Examples of suitable additional direct dyes that may be mentioned include azo direct dyes; (poly)methine dyes such as cyanines, hemicyanines and styryls; carbonyl dyes; azine dyes; nitro(hetero)aryl dyes; tri(hetero)arylmethane dyes; porphyrin dyes; phthalocyanine dyes and natural direct dyes, alone or in the form of mixtures.

The additional direct dyes are preferably cationic direct dyes. Mention may be made of the hydrazono cationic dyes of formulae (Ilia) and (lll'a), the azo cationic dyes (IVa) and (IV'a) and the diazo cationic dyes (Va) below:

Het + -C(R a )=N-N(R b )-Ar, An " Het + -N(R a )-N=C(R b )-Ar, An " Het + -N=N-Ar, An "

(Ilia) (lll'a) (IVa)

Ar + -N=N-Ar", An " and Het + -N=N-Ar'-N=N-Ar, An "

(IVa) (Va) in which formulae (Ilia), (lll'a), (IVa), (IV'a) and (Va):

Het + represents a cationic heteroaryl radical, preferably bearing an endocyclic cationic charge, such as imidazolium, indolium or pyridinium, optionally substituted preferably with one or more (Ci-Cs)alkyl groups such as methyl;

Ar + represents an aryl radical, such as phenyl or naphthyl, bearing an exocyclic cationic charge, preferably ammonium, particularly tri(Ci-C8)alkylammonium such as trimethylammonium;

Ar represents an aryl group, in particular phenyl, which is optionally substituted, preferably with one or more electron-donating groups such as i) optionally substituted (Ci-C8)alkyl, ii) optionally substituted (Ci-Cs)alkoxy, iii) (di)(Ci- C8)(alkyl)amino optionally substituted on the alkyl group(s) with a hydroxyl group, iv) aryl(Ci-C8)alkylamino, v) optionally substituted N-(Ci-C8)alkyl-N-aryl(Ci- C8)alkylamino or, as a variant, Ar represents a julolidine group;

Ar' represents an optionally substituted divalent (hetero)arylene group such as phenylene, particularly para-phenylene, or naphthalene, which are optionally substituted, preferably with one or more groups (Ci-C8)alkyl, hydroxyl or (Ci- Cs)alkoxy;

Ar" represents an optionally substituted (hetero)aryl group such as phenyl or pyrazolyl, which are optionally substituted, preferably with one or more (Ci- Cs)alkyl, hydroxyl, (di)(Ci-C8)(alkyl)amino, (Ci-Cs)alkoxy or phenyl groups;

R a and R b , which may be identical or different, represent a hydrogen atom or a (Ci-Cs)alkyl group, which is optionally substituted, preferably with a hydroxyl group;

or, as a variant, the substituent R a with a substituent of Het + and/or R b with a substituent of Ar and/or R a with R b form, together with the atoms that bear them, a (hetero)cycloalkyl; in particular, R a and R b represent a hydrogen atom or a (Ci-C4)alkyl group, which is optionally substituted with a hydroxyl group;

An " represents an anionic counterion, such as mesylate or halide.

Mention may be made in particular of azo and hydrazono cationic dyes bearing an endocyclic cationic charge of formulae (Ilia), (lll'a) and (IVa) as defined hereinabove. More particularly, those of formulae (Ilia), (lll'a) and (IVa) derived from the dyes described in patent applications WO 95/15144, WO 95/01772 and EP-714954.

Preferably, the cationic part is derived from the following derivatives:

formulae (llla-1 ) and (IVa-1 ) with:

- R 1 representing a (Ci-C4)alkyl group such as methyl;

- R 2 and R 3 , which may be identical or different, represent a hydrogen atom or a (Ci- C 4 )alkyl group, such as methyl; and

- R 4 represent a hydrogen atom or an electron-donating group such as an optionally substituted (Ci-C8)alkyl, optionally substituted (Ci-Cs)alkoxy, or (di)(Ci-C8)(alkyl)amino group optionally substituted on the alkyl group(s) with a hydroxyl group; in particular, R 4 represents a hydrogen atom;

- Z represents a CH group or a nitrogen atom, preferably CH;

- An " represents an anionic counterion, such as mesylate or halide.

In particular, the dye of formulae (llla-1 ) and (IVa-1 ) is chosen from Basic Red 51 , Basic Yellow 87 and Basic Orange 31 or corresponding derivatives:

Among the natural direct dyes that may be used according to the invention, mention may be made of hennotannic acid, juglone, alizarin, purpurin, carminic acid, kermesic acid, purpurogallin, protocatechaldehyde, indigo, isatin, curcumin, spinulosin, apigenidin and orcein. Extracts or decoctions containing these natural dyes and in particular henna- based poultices or extracts may also be used.

When they are present, the additional direct dye(s) more particularly represent from 0.001 % to 10% by weight and preferably from 0.005% to 5% by weight relative to the total weight of the composition.

Among the acidifying agents that may be mentioned, by way of example, are mineral or organic acids, for instance hydrochloric acid, orthophosphoric acid or sulfuric acid, carboxylic acids, for instance acetic acid, tartaric acid, citric acid and lactic acid, and sulfonic acids.

Among the basifying agents, examples that may be mentioned include aqueous ammonia, alkali metal carbonates, alkanolamines such as monoethanolamine, diethanolamine and triethanolamine, and also derivatives thereof, sodium hydroxide, potassium hydroxide and the compounds of formula (III) below: R a RbN-W-NR c Rd in which Z is a linear or branched (Ci-Ce)alkylene group, which is optionally substituted, especially with one or more hydroxyl or amino groups, and preferably Z = propylene optionally substituted with a hydroxyl group or a C1-C4 alkyl radical; R a , Rt>, R c and Rd, which may be identical or different, represent a hydrogen atom or a C1-C4 alkyl or C1-C4 hydroxyalkyl radical.

The cosmetic composition according to the invention may be present in a variety of forms, such as in the form of liquids, creams, gels, or any other form which is appropriate for carrying out dyeing of keratin fibres, and in particular of human hair.

As indicated previously, the invention also relates to the use of the cosmetic composition as defined previously for dyeing keratin fibres, in particular human keratin fibres such as the hair.

///. Dyeing process

The present invention also relates to a process for dyeing keratin fibres, in particular human keratin fibres such as the hair, in one or more steps, comprising the following steps: either the application to said keratin fibres of a cosmetic composition comprising one or more above-mentioned compounds of formula (I), said composition also optionally comprising one or more chemical oxidizing agents as described above; or the sequential application to said keratin fibres, in a first step a), of a composition comprising one or more above-mentioned compounds of formula (I), and then, in a second step b), an oxidizing composition, which comprises one or more chemical oxidizing agents as described above;

it being understood that, between step a) and step b), said fibres may be rinsed, and/or washed and then optionally dried.

Preferably, said cosmetic composition is applied for a leave-on time of between 1 and 60 minutes, preferably between 5 and 40 minutes and even more preferentially between 10 and 30 minutes.

The cosmetic composition is generally applied to the keratin fibres at room temperature, preferably between 25 and 55°C.

According to one embodiment, in the above dyeing process, a composition which comprises one or more above-mentioned compounds of formula (I) is applied to said fibres, and the fibres are then optionally rinsed and/or washed, and said fibres are dried or left to dry.

According to one embodiment, the cosmetic composition according to the invention is applied to keratin fibres, especially human keratin fibres such as the hair, in the presence of one or more chemical oxidizing agents as described above, for a time that is sufficient to obtain the desired lightening.

According to a particular embodiment, the dyeing process according to the invention uses one or more chemical oxidizing agents, as described above, separately from the compound of formula (I) in another cosmetic composition. The two cosmetic compositions may be mixed just before use or may be used separately.

According to one variant, the dyeing process according to the invention consists in applying to keratin fibres, especially human keratin fibres such as the hair, a ready-to-use cosmetic composition which results from the mixing of a cosmetic composition comprising one or more above-mentioned compounds of formula (I) and a cosmetic composition comprising one or more chemical oxidizing agents, as described previously. The ready- to-use cosmetic composition that is thus applied to the keratin fibres may be in various forms, such as in the form of liquids, creams or gels, or in any other form that is suitable for dyeing keratin fibres, and in particular human hair.

Thus, the present invention also relates to a process for lightening keratin fibres, in particular human keratin fibres such as the hair, in which (i) the cosmetic composition comprising, in a suitable dyeing medium, one or more compounds of formula (I) as defined previously, free of chemical oxidizing agent, and (ii) a cosmetic composition comprising one or more chemical oxidizing agents as defined previously are applied to said fibres; compositions (i) and (ii) being applied to said keratin fibres sequentially or simultaneously for a time that is sufficient to obtain the desired lightening, and the fibres are then rinsed, optionally washed with shampoo and rinsed again, and the resulting fibres are dried or left to dry.

The oxidizing composition may also contain various adjuvants conventionally used in cosmetic compositions, in particular compositions for dyeing the hair and as defined previously.

For the purposes of the present invention, the term "sequentially" means that the oxidizing composition is applied before or after the cosmetic composition, i.e. as a pretreatment or a post-treatment, preferably as a pre-treatment. The pH of the oxidizing composition containing the chemical oxidizing agent is such that, after mixing with the cosmetic composition, the pH of the resulting composition applied to the keratin fibres preferably ranges between 2 and 12 approximately, even more preferentially between 3 and 10 and even more particularly between 4 and 9.5. It may be adjusted to the desired value by means of acidifying or basifying agents usually used in the dyeing of keratin fibres and as defined previously.

IV. Compounds of leuco type, cosmetic compositions containing same and dyeing process using same The present invention also relates to compounds of leuco type of formula (II) below, organic or mineral acid or base salts thereof, tautomeric forms, optical isomers or geometrical isomers thereof and/or solvates thereof:

in which formula (II) Xi, X2, Ri, R2, R3, R 4 , R5, R6, n and n' have the same meanings as those indicated previously in formula (I), and it being understood that: Xi and/or X2 comprise at least one permanent cationic charge, and

the compound of formula (II) optionally comprises one or more An " and optionally one or more cations M + to ensure the electrical neutrality of the molecule.

In particular, the preferred variants of n, n', Xi , X2, Ri , R2, R3, R 4 , R5, R6, Re, R9, of the cationic heterocycles, of the non-cationic heterocycles and of the ammonium radicals in formula (II) of the compounds of leuco type correspond to those indicated in formula (I) of the direct dyes.

The compounds of leuco type corresponding to formula (II) are generally obtained by reacting the compounds of azomethine type of formula (I) with a reducing agent according to the reaction scheme below:

Synthetic approaches similar to this scheme are described in patent applications FR 2 056 799, FR 2 047 932, FR 2 165 965 and FR 2 262 023.

The compounds of leuco type of formula (II) are used as precursors of the direct dyes of formula (I).

Preferably, the compounds of leuco type of formula (II) are chosen from compounds (1 ') to (13') corresponding to the reduced form of the azomethine direct dyes (1) to (13) as defined previously, the geometrical or optical isomer forms thereof, the tautomers thereof, the organic or mineral acid or base salts thereof or the solvates thereof such as hydrates, and also mixtures thereof.

(1')

3-(3-{4-[4-amino-5-(4- dimethylaminophenylamino)-2- hydroxyphenylamino]phenylamino } propyl)- 1 - methyl-3 H-imidazo 1- 1 -ium salt

with An " as defined previously.

Preferably, the direct dyes of formula (II) according to the present invention are of structure {V}, ( ), ( ) or (4^), and also the geometrical or optical isomer forms thereof, the tautomers thereof, the organic or mineral acid or base salts thereof or the solvates thereof such as hydrates.

According to the invention, the compounds of formula (II) may optionally be salified with mineral acids, for instance HCI, HBr, H2SO4 or H3PO4, or organic acids, for instance acetic acid, lactic acid, tartaric acid, citric acid, succinic acid, benzenesulfonic acid, para- toluenesulfonic acid, formic acid or methanesulfonic acid.

According to the invention, the compounds of formula (II) may optionally be in the form of solvates, for example a hydrate or a solvate of a linear or branched alcohol, for instance ethanol or isopropanol.

In particular, the invention relates to a cosmetic composition comprising one or more direct dye precursors of formula (II) as defined previously.

Preferably, the cosmetic composition comprises one or more compounds of leuco type of formula (II) chosen from compounds (V) to (13') as defined previously, the geometrical or optical isomer forms thereof, the tautomers thereof, the organic or mineral acid or base salts thereof or the solvates thereof such as hydrates, and also mixtures thereof. Even more preferentially, the cosmetic composition comprises one or more azomethine direct dyes of formula (II) chosen from compounds {V}, (2^), (3J) or (4 ) mentioned previously.

According to one variant of the invention, the cosmetic composition comprises one or more compounds of formulae (I) and (II) as defined above; preferably, the compounds of formula (I) and of formula (II) are chosen from compounds (1 ) to (13) and compounds (1') to (13'), as described above.

According to another variant of the invention, the cosmetic composition is a ready-to- use cosmetic composition, especially for dyeing keratin fibres, in particular human keratin fibres such as the hair, which results from the mixing of a cosmetic composition comprising one or more compounds of the above-mentioned formula (II) and of a cosmetic composition comprising one or more chemical oxidizing agents, as described previously.

According to one variant of the invention, the cosmetic composition does not comprise any chemical oxidizing agent. When the cosmetic composition does not comprise any chemical oxidizing agent, the dyeing of keratin fibres using the leuco compounds of formula (II) is performed with atmospheric oxygen. Simple exposure to air of the keratin fibres, especially human keratin fibres such as the hair, treated with the composition comprising the compound(s) of leuco type makes it possible to generate the colouring species and, consequently, to colour the fibres.

The cosmetic compositions according to these variants may also comprise one or more chemical oxidizing agents, chosen in particular from hydrogen peroxide, urea peroxide, alkali metal bromates, persalts such as perborates and persulfates, peracids, and oxidase enzymes (with the possible cofactors thereof), among which mention may be made of peroxidases, 2-electron oxidoreductases such as uricases, and 4-electron oxygenases, for instance laccases, and preferably, the chemical oxidizing agent is hydrogen peroxide.

The present invention also relates to a process for dyeing keratin fibres, in particular human keratin fibres such as the hair, in one or more steps, comprising the following steps:

either the application to said keratin fibres of a cosmetic composition comprising one or more above-mentioned compounds of formula (II), said composition also optionally comprising one or more chemical oxidizing agents as described above; - or the sequential application to said keratin fibres, in a first step a), of a composition comprising one or more above-mentioned compounds of formula (II), and then, in a second step b), an oxidizing composition, which comprises one or more chemical oxidizing agents as described above; it being understood that, between step a) and step b), said fibres may be rinsed, and/or washed and then optionally dried.

Preferably, said cosmetic composition is applied for a leave-on time of between 1 and 60 minutes, preferably between 5 and 40 minutes and even more preferentially between 10 and 30 minutes.

The cosmetic composition is generally applied to the keratin fibres at room temperature, preferably between 20 and 55°C.

According to a particular embodiment, the present invention also relates to a dyeing process, in one or more steps, in which a cosmetic composition comprising one or more above-mentioned compounds of leuco type of formula (II) is applied to keratin fibres, especially human keratin fibres such as the hair, for a time that is sufficient to develop the desired colouring, optionally after which the fibres are rinsed, optionally washed with shampoo and rinsed again, and the resulting fibres are dried or left to dry.

According to a particular embodiment of the invention, the process for dyeing keratin fibres, especially human keratin fibres such as the hair, does not use any chemical oxidizing agent. When the dyeing process does not use any chemical oxidizing agent, the dyeing operation using the leuco compounds of formula (II) is performed with atmospheric oxygen. Simple exposure to air of the keratin fibres, especially human keratin fibres such as the hair, treated with the composition comprising the compound(s) of leuco type makes it possible to generate the colouring species and, consequently, to colour the fibres.

According to one variant, the dyeing process is a dyeing process in which a cosmetic composition comprising one or more compounds of leuco type of the above-mentioned formula (II) is applied to keratin fibres, especially human keratin fibres such as the hair, in the presence of one or more chemical oxidizing agents as described previously, for a time that is sufficient to develop the desired colouring, optionally after which the fibres are rinsed, optionally washed with shampoo and rinsed again, and the resulting fibres are dried or left to dry.

According to another variant, the dyeing process is a process for dyeing keratin fibres, in particular human keratin fibres such as the hair, in which a ready-to-use cosmetic composition which results from the mixing of a cosmetic composition comprising one or more compounds of formula (II) as defined previously, and of a cosmetic composition comprising one or more chemical oxidizing agents, as described previously, is applied to said fibres. The ready-to-use cosmetic composition that is thus applied to the keratin fibres may be in various forms, such as in the form of liquids, creams or gels, or in any other form that is suitable for dyeing keratin fibres, and in particular human hair. According to one variant, the dyeing process is a sequential dyeing process which consists, in a first stage, in applying to wet or dry keratin fibres, especially human keratin fibres such as the hair, a cosmetic composition comprising one or more leuco compounds of formula (II) as defined previously, followed, in a second stage, by revealing the colour by applying an oxidizing composition containing one or more chemical oxidizing agents as defined previously. This process especially makes it possible to perform clean dyeing, i.e. dyeing that produces very little or no staining of linen and clothing, since the first composition uses compounds of formula (II) that are uncoloured or very sparingly coloured, and the colour is then revealed once said colourless compounds (II) have been applied to the hair, so that the staining of fabrics is avoided during the dyeing process.

According to an advantageous variant, the dyeing process consists in simultaneously applying to wet or dry keratin fibres, especially human keratin fibres such as the hair, a cosmetic composition comprising one or more leuco compounds of formula (II) as defined previously, and an oxidizing composition comprising one or more chemical oxidizing agents as defined previously.

According to another advantageous variant, the chemical oxidizing agent(s) may be applied simultaneously or sequentially to the cosmetic composition comprising the compounds of leuco type of formula (II).

The cosmetic composition comprising the chemical oxidizing agent(s) may be applied to the keratin fibres before, simultaneously with or after the cosmetic composition comprising the compounds of leuco type of formula (II) according to the invention.

According to another variant, the dyeing process consists in applying to keratin fibres, especially human keratin fibres such as the hair, a ready-to-use cosmetic composition which results from the mixing of a cosmetic composition comprising one or more above- mentioned compounds of leuco type of formula (II) and a cosmetic composition comprising one or more chemical oxidizing agents, as described previously. The ready- to-use cosmetic composition that is thus applied to the keratin fibres may be in various forms, such as in the form of liquids, creams or gels, or in any other form that is suitable for dyeing keratin fibres, and in particular human hair.

The leave-on time for the composition(s) ranges from 1 to 60 minutes, preferably from 1 to 40 minutes and even more preferentially from 1 to 30 minutes.

The cosmetic composition comprising such compounds of leuco type is generally applied to the keratin fibres at room temperature, preferably between 20 and 55°C. V. Dyeing device

The present invention also relates to a multi-compartment device or "kit" comprising a first compartment containing one or more compounds of formula (I) and/or (II), and a second compartment containing one or more chemical oxidizing agents as defined above.

In particular, the invention relates to a multi-compartment dyeing device or "kit" comprising a first compartment containing a cosmetic composition comprising one or more direct dyes of formula (I) as defined previously or containing one or more compounds of leuco type of formula (II) as defined previously, and a second compartment comprising one or more chemical oxidizing agents as defined previously.

More particularly, the invention relates to a multi-compartment dyeing device or kit comprising a first compartment containing a cosmetic composition comprising one or more dyes of formula (I) as defined previously, free of chemical oxidizing agent, and a second compartment containing a cosmetic composition comprising one or more chemical oxidizing agents.

According to a particular embodiment, the multi-compartment dyeing device or kit comprises a first compartment containing a cosmetic composition comprising one or more compounds of leuco type of the above-mentioned formula (II), and a second compartment containing a cosmetic composition comprising one or more chemical oxidizing agents.

According to a particular embodiment, the device may comprise at least one compartment comprising a cosmetic composition comprising one or more compounds of leuco type of the above-mentioned formula (II). In this case, the composition comprising the compound(s) of leuco type of formula (II) is applied to the keratin fibres, which become coloured due to their exposure to air.

The devices mentioned above are suitable for dyeing keratin fibres. The invention also relates to the use of one or more compounds of formula (I) and/or (II), optionally in the presence of one or more chemical oxidizing agents as defined previously, for dyeing keratin fibres, in particular human keratin fibres such as the hair.

The examples below are given to illustrate the invention and do not in any way limit the scope thereof.

The compounds were fully characterized via standard spectroscopic or spectrometric methods known to those skilled in the art. Synthesis examples

Synthesis of 3-[3-(4-{4-amino-3-[4-dimethylaminophenyliminol-6-oxocvclohe xa- 1 , 4-dienylamino}phenylamino)propyll- 1 -methyl-3H-imidazol- 1 -ium chloride a)

i) Synthesis of (4)-3-amino-4-{[4-(dimethylamino)phenyllimino}cvclohexa-2,5- dien-1- one (1a)

20 mmol of N,N-dimethylbenzene-1 ,4-diamine dihydrochloride (4.18 g, 1 equivalent) dissolved in 50 ml of water are placed in a 500 ml round-bottomed flask containing 20 mmol of 3-aminophenol dissolved in 14 ml of 1 -pentanol and 50 ml of water. The reaction medium is stirred at room temperature, 60 ml of 20-volumes aqueous hydrogen peroxide solution are then added and the reaction is monitored by TLC. After 72 hours at room temperature, the solid formed is filtered off on a sinter, washed with 15 ml of N,N- dimethylformamide and 3x15 ml of water, suction-filtered and dried in a desiccator (P2O5, vacuum, 40°C) to give compound (1 a) in the form of a very dark purple solid.

The NMR and mass spectrometry analyses are in accordance with the expected structure (1 a).

(1 a)

0.41 mmol of compound (1 a) (100 mg, 1 equivalent), 0.41 mmol of 1 -{3-[(4- aminophenyl)amino]propyl}-3-methyl-1 H-imidazol-3-ium chloride dihydrochloride (141 mg, 1 equivalent) and 0.91 mmol of N,N-diisopropylethylamine (159 μΙ, 2.2 equivalents) are placed in a 25 ml three-necked flask under an inert atmosphere containing 2 ml of ethanol. The reaction medium is stirred at room temperature and the reaction is monitored by HPLC. After 24 hours at room temperature, the reaction medium is concentrated on a rotavapor.

The viscous oil obtained is then taken up in 10 ml of acetonitrile and the insoluble black matter present in the solution is filtered off on a sinter, washed with 2x5 ml of acetonitrile, suction-filtered and then dried in a desiccator (P2O5, vacuum, 40°C) to give compound (a) in the form of a black solid.

The NMR and mass spectrometry analyses are in accordance with the expected structure

(a).

• Synthesis of 1-(3-{[4-({2-amino-5-[(4-{[3-(3-meth yl- 1 H-imidazol-3-ium- 1 - yl)propyllamino}phenyl)aminol-4-oxocvclohexa-2,5-dien-1- ylidene}amino)phenyllamino}propyl)-3-methyl-1H-imidazol-3-iu m dichloride

i) Synthesis of 4-(benzyloxy)-1 -fluoro-2-nitrobenzene (1b)

63.65 mmol of 4-fluoro-3-nitrophenol (10.0 g, 1 equivalent) are placed in a 500 ml three- necked flask containing 150 ml of acetonitrile. The reaction medium is stirred at room temperature, and 66.84 mmol of potassium carbonate (9.23 g, 1 .05 equivalents) and 66.84 mmol of benzyl bromide (7.95 ml, 1 .05 equivalents) are then added. The solution is heated to 80°C and the reaction is monitored by TLC (dichloromethane/methanol: 95/5). After 1 hour at 80°C, the reaction medium is poured onto ice. The precipitate formed is filtered off on a sinter to give, after washing with water, suction filtration and then drying (P2O5, vacuum, 40°C), compound (1 b) obtained in the form of a yellow powder.

The NMR and mass spectrometry analyses are in accordance with the expected structure (1 b). ii) Synthesis of 1 -{3-f(4-{[4-(benzyloxy)-2- nitrophenyllamino}phenyl)aminolpropyl}-3-methyl-1H-imidazol- 3-ium chloride

4.04 mmol of compound (1 b) (1.0 g, 1 equivalent), 4.04 mmol of 1 -{3-[(4- aminophenyl)amino]propyl}-3-methyl-1 H-imidazol-3-ium chloride dihydrochloride (1 .37 g, 1 .0 equivalent), 12.52 mmol of N,N-diisopropylethylamine (2.20 ml, 3.1 equivalents) and 10 ml of 1 -butanol are placed in a 50 ml three-necked flask under an inert atmosphere. The reaction medium is heated to 1 10°C and the reaction is monitored by HPLC. After 24 hours at 1 10°C, the heating is stopped and the reaction medium is then evaporated on a rotavapor.

The viscous oil obtained is then purified by chromatography on neutral alumina using an eluent constituted of a mixture of dichloromethane and methanol.

Compound (2b) is obtained in the form of a dark red solid. The NMR and mass spectrometry analyses are in accordance with the expected structure (2b).

Hi) Synthesis of 1-(3-{[4-({2-amino-5-[(4-{[3-(3-meth yl- 1 H-imidazol-3-ium- 1 - yl)propyllamino}phenyl)aminol-4-oxocvclohexa-2,5-dien-1- ylidene}amino)phenyllamino}propyl)-3-methyl-1H-imidazol-3-iu m dichloride

non-isolated crude reaction product

product

(b) 2.83 mmol of compound (2b) (1 .40 g, 1 equivalent) and 1 .0 g of 5% palladium on charcoal are placed in a 100 ml three-necked flask under an inert atmosphere containing 20 ml of methanol. The reaction medium is heated to 65°C, 28.3 mmol of cyclohexene (2.9 ml, 10 equivalents) are then added dropwise and the reaction is monitored by HPLC. After 2 hours at 65°C, the reaction medium is filtered through a sinter packed with Celite. The filtrate is stirred at room temperature for 30 minutes and is then evaporated. The dark blue viscous oil obtained (1 .05 g, 2.83 mmol, 1 equivalent), 2.83 mmol of 1 -{3-[(4- aminophenyl)amino]propyl}-3-methyl-1 H-imidazol-3-ium chloride dihydrochloride (959 mg, 1 equivalent) and 8.46 mmol of N,N-diisopropylethylamine (1 .48 ml, 3 equivalents) are placed in a 100 ml three-necked flask under an inert atmosphere containing 15 ml of ethanol. The reaction medium is stirred at room temperature and the reaction is monitored by HPLC. After 48 hours at room temperature, the reaction medium is concentrated on a rotavapor.

The viscous oil obtained is then purified by chromatography on neutral alumina using an eluent constituted of a mixture of dichloromethane and methanol. Compound (b) is obtained in the form of a black solid.

The NMR and mass spectrometry analyses are in accordance with the expected structure (b).

Synthesis of 3-[3-(4-{4-amino-3-[4-(ethylisopropylamino)phenyliminol-6- oxocyclohexa- 1 , 4-dien ylamino}phenylamino)propyll- 1 -meth yl-3H-imidazol- 1 -ium chloride

(c)

Synthesis of N'-[4-(benzyloxy)-2-nitrophenyll-N-ethyl-N-(propan-2-yl)benz ene- 1,4-diamine (1c)

40.45 mmol of compound (1 b) (1 .0 g, 1 equivalent), 42.47 mmol of N-ethyl-N-(propan-2- yl)benzene-1 ,4-diamine hydrochloride (9.12g, 1 .05 equivalents), 84.95 mmol of diisopropylethylamine (14.8 ml, 2.1 equivalents) and 100 ml of 1 -butanol are placed in a 500 ml three-necked flask under an inert atmosphere. The reaction medium is heated to 1 10°C and the reaction is monitored by HPLC. After 48 hours at 1 10°C, the heating is stopped and the reaction medium is then stirred at room temperature. After 3 hours at room temperature, the dark brown precipitate formed in the reaction medium is filtered off on a sinter, washed with 3x200 ml of ethanol, suction-filtered and then dried in a desiccator (P2O5, vacuum, 40°C) to give compound (1 c) in the form of a dark red solid.

The NMR and mass spectrometry analyses are in accordance with the expected structure (1 c). ii) Synthesis of 3-[3-(4-{4-amino-3-[4-(ethylisopropylamino)phenyliminol-6- oxocyclohexa- 1 , 4-dien ylamino}phenylamino)propyll- 1 -meth yl-3H-imidazol- 1 - ium chloride (c)

2.47 mmol of compound (1 c) (1.0 g, 1 equivalent) and 0.5 g of 5% palladium on charcoal are placed in a 100 ml three-necked flask under an inert atmosphere containing 20 ml of methanol. The reaction medium is heated to 65°C, 24.7 mmol of cyclohexene (2.5 ml, 10 equivalents) are then added dropwise and the reaction is monitored by HPLC. After 2 hours at 65°C, the reaction medium is filtered through a sinter packed with Celite. The filtrate is stirred at room temperature for 30 minutes and is then evaporated. The dark blue viscous oil obtained (700 mg, 2.47 mmol, 1 equivalent), 2.47 mmol of 1 -{3-[(4- aminophenyl)amino]propyl}-3-methyl-1 H-imidazol-3-ium chloride dihydrochloride (839 mg, 1 equivalent) and 5.06 mmol of N,N-diisopropylethylamine (882 μΙ, 2.1 equivalents) are placed in a 100 ml three-necked flask under an inert atmosphere containing 15 ml of ethanol. The reaction medium is stirred at room temperature and the reaction is monitored by HPLC. After 48 hours at room temperature, the reaction medium is evaporated on a rotavapor.

The viscous oil obtained is then purified by chromatography on neutral alumina using an eluent constituted of a mixture of dichloromethane and methanol.

Compound (c) is obtained in the form of a black solid.

The NMR and mass spectrometry analyses are in accordance with the expected structure (c).

Synthesis of 3-{3-f4-(4-amino-3-{(4-fbis(2-hydroxyethyi)aminolphenyiimino }-6- oxocyclohexa- 1 , 4-dien ylamino)phen ylaminolpropyl}- 1 -meth yl-3H-imidazol- 1 -ium chloride (d)

i) Synthesis of 2,2'-[(4-{[4-(benzyioxy)-2- nitrophenyllaminojphenvDiminoldiethanol (1d)

40.45 mmol of compound (1 b) (10.0 g, 1 equivalent), 40.45 mmol of 2,2'-[(4- aminophenyl)imino]diethanol sulfate hydrate (12.63 g, 1 .0 equivalent), 125.24 mmol of diisopropylethylamine (21.8 ml, 3.1 equivalents) and 75 ml of 1 -butanol are placed in a 500 ml three-necked flask under an inert atmosphere. The reaction medium is heated to 1 10°C and the reaction is monitored by HPLC. After 48 hours at 1 10°C, the heating is stopped and the reaction medium is then stirred at room temperature. After 4 hours at room temperature, the dark brown precipitate formed in the reaction medium is filtered off on a sinter, washed with 3x200 ml of ethanol, suction-filtered and then dried in a desiccator (P2O5, vacuum, 40°C) to give compound (1 d) in the form of a dark red solid. The NMR and mass spectrometry analyses are in accordance with the expected structure (1 d).

ΊΊ) Synthesis of 3-{3-[4-(4-amino-3-{(4-[bis(2-hvdroxyethyl)aminolphenylimino }-6- oxocyclohexa- 1 , 4-dien ylamino)phen ylaminolpropyl}- 1 -meth yl-3H-imidazol- 1 - ium chloride (d)

non-isolated product crude reaction product

35.42 mmol of compound (1 d) (15.0 g, 1 equivalent) and 8.0 g of 5% palladium on charcoal are placed in a 500 ml three-necked flask under an inert atmosphere containing 150 ml of methanol. The reaction medium is heated to 65°C, 354.2 mmol of cyclohexene (35.9 ml, 10 equivalents) are then added dropwise and the reaction is monitored by HPLC. After 2 hours at 65°C, the reaction medium is filtered through a sinter packed with Celite. The filtrate is stirred at room temperature for 30 minutes and is then evaporated. The dark blue viscous oil obtained (10.67 g, 35.42 mmol, 1 equivalent), 35.42 mmol of 1 - {3-[(4-aminophenyl)amino]propyl}-3-methyl-1 H-imidazol-3-ium chloride dihydrochloride (12.03 g, 1 equivalent) and 74.38 mmol of N,N-diisopropylethylamine (12.96 ml, 2.1 equivalents) are placed in a 500 ml three-necked flask under an inert atmosphere containing 200 ml of ethanol. The reaction medium is stirred at room temperature and the reaction is monitored by HPLC. After 48 hours at room temperature, the reaction medium is concentrated on a rotavapor. The viscous oil obtained is then purified by chromatography on neutral alumina using an eluent constituted of a mixture of dichloromethane and methanol.

Compound (d) is obtained in the form of a black solid. The NMR and mass spectrometry analyses are in accordance with the expected structure (d).

Examples of dyeing evaluation:

Cosmetic compositions 1 to 6 below were prepared:

2.0 g of compositions 1 to 4 are applied to a 1 .0 g lock of grey hair containing 90% white hairs. After a leave-on time of 30 minutes at room temperature, the lock is rinsed, washed with a standard shampoo and then dried.

Spectrocolorimetric evaluation:

The colour of the locks was evaluated in the CIE L * a * b * system using a Minolta Spectrophotometer CM3610D colorimeter. In this L * a * b * system, the three parameters respectively denote the intensity of the colour (L * ), the green/red colour axis (a * ) and the blue/yellow colour axis (b * ).

Colour build-up:

The variation in colouration between the non-dyed and dyed locks of hair is defined by (ΔΕ * ) according to the following equation: A E * = yl(L * -L 0 *) 2 + (a* - a 0 *) 2 + (b* -b 0 *) 2

In this equation, L*, a* and b* represent the values measured on locks of hair after dyeing and Lo*, ao* and bo* represent the values measured on locks of hair before dyeing. The higher the value of ΔΕ*, the greater the colour build-up.

Results:

The colours obtained on the lock thus treated are collated in the attached table:

It is seen through these results that the compositions according to the invention give intense hair colourings and with good colour build-up.

Comparative examples:

The following dye compositions A (comparative) and B (invention) were prepared from the ingredients indicated in the table below. The contents are expressed as percentages of active material relative to the total weight of the composition.

Compound 1 (comparative) Compound 2 (invention)

Composition A Composition B

(comparative) (invention)

Compound 1 0.5 -

Compound 2 - 0.5

Water 79.5 79.5

Pure ethyl alcohol 15 15

Benzyl alcohol 5 5 Process

2 g of each of the compositions are applied to 1 g locks of natural Caucasian hair containing 90% white hairs. After 30 minutes, the locks are rinsed, shampooed and then dried. The colorimetric data of each of the locks are then measured with a Minolta CM- 361 Od spectrophotometer.

Results

The results are given in the table below.

It is seen from the above table that the colour obtained with the comparative composition A is significantly lighter than that obtained with composition B according to the invention. It was not possible to obtain a black shade with the comparative composition A, whereas composition B according to the invention makes it possible to obtain a very intense grey- black colour.