Title:
NOVEL BAX VARIANT AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2024/035023
Kind Code:
A1
Abstract:
The present invention provides: a Bax protein variant in which lysine at position 128, lysine at position 190, or lysines at positions 128 and 190 in a Bax protein is(are) substituted with arginine; a method for increasing the half-life of a Bax protein, the method comprising substituting lysine at position 128, lysine at position 190, or lysines at positions 128 and 190 in the Bax protein with arginine; a pharmaceutical composition comprising the Bax protein variant; and a method for screening for an anticancer substance. The Bax protein variant according to the present invention can inhibit a mechanism of protein degradation through ubiquitination and exhibits a longer half-life than wild-type Bax.
Inventors:
BAEK KWANG-HYUN (KR)
CHOI HAE-SEUL (KR)
CHOI HAE-SEUL (KR)
Application Number:
PCT/KR2023/011541
Publication Date:
February 15, 2024
Filing Date:
August 07, 2023
Export Citation:
Assignee:
UNIV CHA IND ACAD COOP FOUND (KR)
International Classes:
C07K14/47; A61K38/00; A61P35/00; G01N33/50
Foreign References:
| KR20190016263A | 2019-02-18 | |||
| US5691179A | 1997-11-25 | |||
| US5702897A | 1997-12-30 | |||
| US20020052316A1 | 2002-05-02 |
Other References:
DATABASE Protein 19 March 2015 (2015-03-19), ANONYMOUS : "BAX, partial [synthetic construct]", XP093138235, retrieved from NCBI Database accession no. AIC48347.1
Attorney, Agent or Firm:
OH, Kook-Jin (KR)
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