Title:
NOVEL BCR-ABL KINASE INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2016/165205
Kind Code:
A1
Abstract:
Disclosed is a BCR-ABL kinase inhibitor. The BCR-ABL kinase inhibitor comprises a compound of formula I or a pharmaceutically acceptable salt, a solvate, an ester, an acid, a metabolite or a prodrug thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined in the specification. Also disclosed are a pharmaceutical composition comprising the compound of formula I and a use of the compound in the present invention in preparation of drugs for treating a disease activated and mediated by the BCR-ABL kinase. ![]()
Inventors:
LIU JING (CN)
LIU QINGSONG (CN)
LIANG XIAOFEI (CN)
WANG BEILEI (CN)
WANG AOLI (CN)
LIU XIAOCHUAN (CN)
CHEN CHENG (CN)
QI ZIPING (CN)
WANG WENCHAO (CN)
ZHAO ZHENG (CN)
WANG LI (CN)
LIU QINGSONG (CN)
LIANG XIAOFEI (CN)
WANG BEILEI (CN)
WANG AOLI (CN)
LIU XIAOCHUAN (CN)
CHEN CHENG (CN)
QI ZIPING (CN)
WANG WENCHAO (CN)
ZHAO ZHENG (CN)
WANG LI (CN)
Application Number:
PCT/CN2015/081220
Publication Date:
October 20, 2016
Filing Date:
June 11, 2015
Export Citation:
Assignee:
HEFEI INST PHYSICAL SCI CAS (CN)
HEFEI COSOURCE PHARMACEUTICAL CO LTD (CN)
HEFEI COSOURCE PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D239/48; A61K31/506; A61P35/00; C07D239/47; C07D239/56
Domestic Patent References:
| WO2007059157A1 | 2007-05-24 | |||
| WO2008144253A1 | 2008-11-27 |
Foreign References:
| CN101023063A | 2007-08-22 | |||
| CN101080396A | 2007-11-28 | |||
| CN101522636A | 2009-09-02 | |||
| CN1898208A | 2007-01-17 | |||
| CN1842529A | 2006-10-04 |
Attorney, Agent or Firm:
SHANGCHENG & PARTNERS (CN)
北京尚诚知识产权代理有限公司 (CN)
北京尚诚知识产权代理有限公司 (CN)
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