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Title:
NOVEL BENZAZEPINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2014/104209
Kind Code:
A1
Abstract:
The objective of the present invention is to provide a compound which has V2 receptor agonistic activity. A pharmaceutical composition which contains, as an active ingredient, a compound represented by general formula (I) or a pharmacologically acceptable salt thereof. (In general formula (I), R1 represents a group represented by formula (2) or the like; R2 represents a hydrogen atom or a lower alkyl group; R3 represents a lower alkyl group which may be substituted by 1-3 fluorine atoms, or a halogen atom; R4 represents a five-membered aromatic monocyclic heterocyclic group, a five-membered non-aromatic monocyclic heterocyclic group or the like (provided that these heterocyclic groups have at least one nitrogen atom and may be substituted by a lower alkyl group); and R5 represents a lower alkyl group, a halogen atom or the like.) (In formula (2), A represents a lower alkylene group which may be substituted by a lower alkyl group, or the like; R6 represents a hydrogen atom or the like; and R7 represents a hydroxyl group, an aromatic heterocyclic group which may be substituted by a lower alkyl group, a carbamoyl group or the like.)

Inventors:
KITAMOTO KATSUNORI (JP)
KASUGAI NOBUYOSHI (JP)
KATAOKA HIROYO (JP)
OHSAWA YASUSHI (JP)
KUNO YUKA (JP)
FUJIEDA HIROKI (JP)
SAKAI KEITA (JP)
NAGANO HIROKI (JP)
TAKAHASHI NAOKI (JP)
IZUCHI TORU (JP)
TAKEUCHI MITSUAKI (JP)
KURUMAZUKA DAISUKE (JP)
MIYAZAWA TOSHIYUKI (JP)
HARADA SATOKO (JP)
GOTOH IZUMI (JP)
ASANO YUKIYASU (JP)
YAMADA YURIE (JP)
OKABE MORIO (JP)
Application Number:
PCT/JP2013/084937
Publication Date:
July 03, 2014
Filing Date:
December 26, 2013
Export Citation:
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Assignee:
SANWA KAGAKU KENKYUSHO CO (JP)
International Classes:
C07D223/16; A61K31/55; A61P7/04; A61P13/00; A61P13/10; A61P43/00; C07D403/10; C07D413/10
Domestic Patent References:
WO2006104008A12006-10-05
WO1995034540A11995-12-21
WO1997022591A11997-06-26
WO2006104008A12006-10-05
WO2005037795A22005-04-28
Foreign References:
JPH1081668A1998-03-31
JPH04321669A1992-11-11
JPH04154765A1992-05-27
JP2010504352A2010-02-12
JP2004323372A2004-11-18
US4952573A1990-08-28
JPH09221476A1997-08-26
JP2000351768A2000-12-19
JPH1160488A1999-03-02
JPH111456A1999-01-06
Other References:
"AZABENZOCYCLOHEPTENONES. PART XVII. SOME SUBSTITUTION REACTIONS IN TETRAHYDRO-1-BENZAZEPIN-5-ONES", J.CHEM.SOC.,PERKIN TRANS.I, vol. 1974, 1974, pages 1828 - 1833, XP002303553
See also references of EP 2940008A4
"Protecting Groups in Organic Synthesis", 1999, WILEY
Attorney, Agent or Firm:
SAKAMOTO TOMOHIRO (JP)
Tomohiro Sakamoto (JP)
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