NOVEL BENZENE-FUSED HETEROCYCLIC DERIVATIVES OR SALTS THEREOF

Title:

NOVEL BENZENE-FUSED HETEROCYCLIC DERIVATIVES OR SALTS THEREOF

Document Type and Number:

WIPO Patent Application WO/1999/037643

Kind Code:

A1

Abstract:

Benzene-fused heterocyclic derivatives represented by general formula (I) or salts thereof, wherein each symbol has the following meaning: R?1¿: (a) or (b); A: -CH=CR?4¿-CH¿2?-, -CH¿2?-CH¿2?-CH¿2?-, -NR?5¿-CO-CH¿2?- or -O-CH¿2?-CH¿2?-; X: a bond, -CO-, -CO-O- or -SO¿2?-; Y: lower alkylene, -NR?6¿-CO-, -CH¿2?-NR?6¿-CO-, -NR?6¿-(lower alkylene) or -CR?7¿=CH-; R?2¿: hydrogen or lower alkyl, or forming -CH=CH-. Because of having anticoagulant effects based on inhibition of activated blood coagulation factor X, these compounds are useful as blood anticoagulants or preventives/remedies for diseases induced by thrombosis or embolism.

Inventors:

HIRAYAMA FUKUSHI (JP)
KOSHIO HIROYUKI (JP)
ISHIHARA TSUKASA (JP)
KAIZAWA HIROYUKI (JP)
KATAYAMA NAOKO (JP)
TANIUCHI YUTA (JP)
MATSUMOTO YUZO (JP)

Application Number:

PCT/JP1999/000276

Publication Date:

July 29, 1999

Filing Date:

January 25, 1999

Export Citation:

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Assignee:

YAMANOUCHI PHARMA CO LTD (JP)
HIRAYAMA FUKUSHI (JP)
KOSHIO HIROYUKI (JP)
ISHIHARA TSUKASA (JP)
KAIZAWA HIROYUKI (JP)
KATAYAMA NAOKO (JP)
TANIUCHI YUTA (JP)
MATSUMOTO YUZO (JP)

International Classes:

C07D285/16; C07D401/12; C07D413/12; C07D417/12; (IPC1-7): C07D417/12; A61K31/445; A61K31/47; A61K31/54; C07D243/12; C07D401/04; C07D401/12; C07D417/04

Domestic Patent References:

WO1996016940A1	1996-06-06
WO1998003202A1	1998-01-29
WO1998026803A1	1998-06-25
WO1999005124A1	1999-02-04

Attorney, Agent or Firm:

Nagai, Shozo (Ltd. Patent Dept. 17-1, Hasune 3-chome Itabashi-ku Tokyo, JP)

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