Title:
NOVEL BENZIMIDAZOLE COMPOUND AND PHARMACEUTICAL USE OF SAME
Document Type and Number:
WIPO Patent Application WO/2017/043636
Kind Code:
A1
Abstract:
To provide a therapeutic agent for diseases associated with Nav 1.7, specifically diseases such as neuropathic pain, nociceptive pain, inflammatory pain, small fiber neuropathy, erythromelalgia, paroxysmal extreme pain disorder, urination disorders and multiple sclerosis.
Provided is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof.
(In the formula, each of R1a, R1b, R1c and R1d represents a hydrogen atom, a halogen atom, a cyano group, a C1-4 alkyl group, a C1-4 alkoxy group or the like, provided that at least one of the R1a, R1b, R1c and R1d moieties represents a C6-10 aryl group, a C6-10 aryloxy group or the like; each of R2 and R3 represents a hydrogen atom, a C1-6 alkyl group, a C3-10 cycloalkyl group or the like; R4 represents a hydrogen atom, a C1-6 alkyl group, a C3-7 cycloalkyl group or the like; m represents 1, 2 or 3; L represents a CR7R8 group; and each of R7 and R8 represents a hydrogen atom, a hydroxyl group, a C1-4 alkyl group, a C1-4 alkoxy group or the like.)
Inventors:
KOMIYA MASAFUMI (JP)
IWAMOTO KOHEI (JP)
KANAI TOSHIO (JP)
MIZUSHIMA SHINGO (JP)
ADACHI KEIJI (JP)
URASHIMA KUNIKO (JP)
IWAMOTO KOHEI (JP)
KANAI TOSHIO (JP)
MIZUSHIMA SHINGO (JP)
ADACHI KEIJI (JP)
URASHIMA KUNIKO (JP)
Application Number:
PCT/JP2016/076645
Publication Date:
March 16, 2017
Filing Date:
September 09, 2016
Export Citation:
Assignee:
SUMITOMO DAINIPPON PHARMA CO LTD (JP)
International Classes:
A61K31/4184; C07D235/06; A61K31/423; A61K31/4439; A61K31/497; A61K31/501; A61K31/506; A61K31/5375; A61P13/00; A61P25/00; A61P25/04; C07D401/04; C07D401/12; C07D403/06; C07D403/12; C07D405/06; C07D407/14; C07D413/04
Domestic Patent References:
| WO2016117647A1 | 2016-07-28 | |||
| WO2015008861A1 | 2015-01-22 | |||
| WO2016057834A1 | 2016-04-14 |
Foreign References:
| JP2015509110A | 2015-03-26 | |||
| US20150133500A1 | 2015-05-14 | |||
| JP2013530180A | 2013-07-25 | |||
| JP2008501714A | 2008-01-24 | |||
| US20140275011A1 | 2014-09-18 | |||
| JP2005529895A | 2005-10-06 |
Other References:
HAY, D. A. ET AL.: "Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 136, no. 26, 2014, pages 9308 - 9319, XP055135823
Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (JP)
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