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Title:
NOVEL BENZOTHIAZEPINE AND BENZOTHIEPINE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2005/082874
Kind Code:
A1
Abstract:
It is intended to provide a drug useful as a remedy and a preventive for hyperlipemia; a drug also useful as a remedy and a preventive for liver disorders accompanying bile stasis, in particular, primary biliary cirrhosis, primary sclerotic cholantitis and so on; and a drug useful as a remedy and a preventive for obesity, fatty liver and fatty hepatitis. A benzothiazepine or benzothiepine compound represented by the following general formula (1A) which has a thioamide bond and a quaternary ammonium substituent.

Inventors:
Sasahara, Takehiko (95 Magome, Numazu-shi, Shizuoka 05, 41001, JP)
Mohri, Mitsunobu (2-4-16, Higashihoncho Mishima-shi, Shizuoka 31, 41108, JP)
Kasahara, Ken-ichi (134-1, Jike Nirayama-cho, Tagata-gun Shizuoka 22, 41021, JP)
Application Number:
PCT/JP2005/003686
Publication Date:
September 09, 2005
Filing Date:
February 25, 2005
Export Citation:
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Assignee:
ASAHI KASEI PHARMA CORPORATION (9-1 Kanda Mitoshiro-cho, Chiyoda-ku, Tokyo 81, 10184, JP)
Sasahara, Takehiko (95 Magome, Numazu-shi, Shizuoka 05, 41001, JP)
Mohri, Mitsunobu (2-4-16, Higashihoncho Mishima-shi, Shizuoka 31, 41108, JP)
Kasahara, Ken-ichi (134-1, Jike Nirayama-cho, Tagata-gun Shizuoka 22, 41021, JP)
International Classes:
A61K31/22; A61K31/366; A61K31/38; A61K31/381; A61K31/395; A61K31/4025; A61K31/428; A61K31/439; A61K31/4995; A61K31/5375; A61K31/541; A61K31/554; A61P1/16; A61P3/04; A61P3/06; A61P9/10; C07D281/10; C07D285/36; C07D337/08; C07D409/12; C07D453/02; C07D471/08; C07D487/08; (IPC1-7): C07D281/10; A61K31/22; A61K31/366; A61K31/38; A61K31/381; A61K31/395; A61K31/4025; A61K31/428; A61K31/439; A61K31/4995; A61K31/5375; A61K31/541; A61K31/554; A61P1/16; A61P3/04; A61P3/06; A61P9/10; C07D337/08; C07D409/12; C07D453/02; C07D471/08; C07D487/08
Domestic Patent References:
WO2002008211A2
WO2002050051A1
WO2004020421A1
Foreign References:
JP2002519418A
JP2002536440A
JP2002541248A
JP2002533413A
Other References:
TELFORD D.E. ET AL: 'Inhibition of both the apical sodium-dependent bile acid transporter and HMG CoA reductase markedly enhances the clearance of LDL apoB.' J.LIPID RES., vol. 44, no. 5, 2003, pages 943 - 952, XP002989164
See also references of EP 1719768A1
Attorney, Agent or Firm:
Sakai, Hiroaki (Sakai International Patent Office, Kasumigaseki Building 2-5, Kasumigaseki 3-chom, Chiyoda-ku Tokyo, 100-6019, JP)
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