Title:
NOVEL BENZOXAZINE DERIVATIVE AND MEDICINE COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2016/006593
Kind Code:
A1
Abstract:
Provided are an amyloid fibril formation inhibitor and a therapeutic or prophylactic drug for neurodegenerative diseases, said inhibitor and drug comprising a compound represented by general formula (I), a pharmaceutically acceptable salt thereof or a solvate of the same.
In general formula (I): X represents an oxygen atom, etc.; Y represents -CH2-, etc.; Z represents -(CH2)l-C(O)-(CH2)m-NH-(CH2)n-, etc.; Ar represents an aryl group or a heteroaryl group; R1 and R2 independently represent a hydrogen atom, an alkyl group, an alkoxyalkyl group, etc., or R1 and R2 may together form a ring; R3 represents a hydrogen atom, a halogen atom, an alkyl group, a cycloalkyl group, an alkoxy group, etc.; and R4 represents a hydrogen atom, etc.
Inventors:
YANAGISAWA KATSUHIKO (JP)
KAWAI AKIYOSHI (JP)
FURUYA TOSHIO (JP)
TAKAYAMA KIYOSHI (JP)
SHIMIZU TOMOKO (JP)
KAWAI AKIYOSHI (JP)
FURUYA TOSHIO (JP)
TAKAYAMA KIYOSHI (JP)
SHIMIZU TOMOKO (JP)
Application Number:
PCT/JP2015/069487
Publication Date:
January 14, 2016
Filing Date:
July 07, 2015
Export Citation:
Assignee:
NAT CT GERIATRICS & GERONTOLOGY (JP)
PHARMADESIGN INC (JP)
NB HEALTH LAB CO LTD (JP)
PHARMADESIGN INC (JP)
NB HEALTH LAB CO LTD (JP)
International Classes:
A61K31/538; A61K31/47; A61P25/28
Domestic Patent References:
| WO2007062007A1 | 2007-05-31 | |||
| WO2015080904A1 | 2015-06-04 |
Foreign References:
| JP2012514038A | 2012-06-21 | |||
| JP2003113147A | 2003-04-18 |
Other References:
DATABASE REGISTRY [o] retrieved from STN Database accession no. 924142-40-5
DATABASE REGISTRY [o] retrieved from STN Database accession no. 950150-67-1
DATABASE REGISTRY [o] retrieved from STN Database accession no. 950150-67-1
Attorney, Agent or Firm:
OKUYAMA, Shoichi et al. (JP)
Okuyama In addition, it is 1. (JP)
Okuyama In addition, it is 1. (JP)
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