Title:
NOVEL BENZYLIDENE DIHYDROINDENONE DERIVATIVE, AND COMPOSITION FOR PREVENTING OR TREATING INFLAMMATORY BOWEL DISEASE, CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2016/195361
Kind Code:
A1
Abstract:
The present invention provides: a novel benzylidene dihydroindenone derivative; and a composition for preventing or treating inflammatory bowel disease, containing the same. The benzylidene dihydroindenone derivative maintains the thickness of the small intestine and the length of the large intestine to be like the normal states thereof and has excellent inflammation inhibitory activity in the large intestine, thereby being useful in the prevention or treatment of inflammatory bowel disease.
Inventors:
LEE EUNG-SEOK (KR)
KIM JUNG-AE (KR)
JEONG TAE-CHEON (KR)
KIM JUNG-AE (KR)
JEONG TAE-CHEON (KR)
Application Number:
PCT/KR2016/005735
Publication Date:
December 08, 2016
Filing Date:
May 31, 2016
Export Citation:
Assignee:
UNIV YEUNGNAM RES COOPERATION FOUNDATION (KR)
International Classes:
C07C49/633; A61K31/122; C07C49/443; C07D307/34; C07D333/12
Other References:
BANSAL, RANJU ET AL.: "Synthesis of Some Imidazolyl-substituted 2-Benzylidene Indanone Derivatives as Potent Aromatase Inhibitors for Breast Cancer Therapy", MED. CHEM. RES., vol. 20, 2011, pages 661 - 669, XP019914674
DIMMOCK, JONATHAN R. ET AL.: "Conformational and Quantitative Structure-activity Relationship Study of Cytotoxic 2-Arylidenebenzocycloalkanones", J. MED. CHEM., vol. 42, 1999, pages 1358 - 1366, XP002422719
SARBAGYA D. P. ET AL.: "Synthesis of Pyrido[3,2-b]Benzofurans", INDIAN JOURNAL OF CHEMISTRY, vol. 25 R, 1986, pages 891 - 893, XP002912313
GIRGIS, ADD S. ET AL.: "Regoselective Synthesis of Dispiro [aH-Indene-2,3', Pyrrolidine-2',3''-[3H]Indole]-1,2''(1''H)-Diones of Potential Anti-tumor Properties", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 44, no. 1, 2009, pages 91 - 100, XP025842149
DIMMOCK, JONATHAN R. ET AL.: "Conformational and Quantitative Structure-activity Relationship Study of Cytotoxic 2-Arylidenebenzocycloalkanones", J. MED. CHEM., vol. 42, 1999, pages 1358 - 1366, XP002422719
SARBAGYA D. P. ET AL.: "Synthesis of Pyrido[3,2-b]Benzofurans", INDIAN JOURNAL OF CHEMISTRY, vol. 25 R, 1986, pages 891 - 893, XP002912313
GIRGIS, ADD S. ET AL.: "Regoselective Synthesis of Dispiro [aH-Indene-2,3', Pyrrolidine-2',3''-[3H]Indole]-1,2''(1''H)-Diones of Potential Anti-tumor Properties", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 44, no. 1, 2009, pages 91 - 100, XP025842149
Attorney, Agent or Firm:
OH, KOOK-JIN (KR)
오국진 (KR)
오국진 (KR)
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