Title:
NOVEL BETA-AMYLOID INHIBITORS, METHOD FOR PRODUCING THE SAME AND THE USE THEREOF AS MEDICAMENTS
Document Type and Number:
WIPO Patent Application WO2002014313
Kind Code:
A3
Abstract:
The invention relates to compounds of the general formula (I), wherein the residues A, Het, R<1>, R<2> and R<3> have the meanings indicated in the description and the claims. The invention further relates to methods for producing said compounds and to the use of compounds of the general formula (I) as medicaments, especially as medicaments having a beta-amyloid inhibiting effect.
Inventors:
FUCHS KLAUS (DE)
ROMIG MICHAEL (DE)
MENDLA KLAUS (DE)
BRIEM HANS (DE)
FECHTELER KATJA (DE)
ROMIG MICHAEL (DE)
MENDLA KLAUS (DE)
BRIEM HANS (DE)
FECHTELER KATJA (DE)
Application Number:
PCT/EP2001/008456
Publication Date:
May 23, 2002
Filing Date:
July 21, 2001
Export Citation:
Assignee:
BOEHRINGER INGELHEIM PHARMA (DE)
FUCHS KLAUS (DE)
ROMIG MICHAEL (DE)
MENDLA KLAUS (DE)
BRIEM HANS (DE)
FECHTELER KATJA (DE)
FUCHS KLAUS (DE)
ROMIG MICHAEL (DE)
MENDLA KLAUS (DE)
BRIEM HANS (DE)
FECHTELER KATJA (DE)
International Classes:
A61K31/437; A61K31/4545; A61K31/496; A61K31/5377; A61P25/14; A61P25/16; A61P25/28; A61P43/00; C07D471/04; (IPC1-7): C07D471/04; A61P25/28
Foreign References:
| EP0092458A2 | 1983-10-26 | |||
| US6030984A | 2000-02-29 |
Other References:
TRAPANI G ET AL: "Synthesis and Binding Affinity of 2-Phenylimidazo[1,2-alpha]pyridine Derivatives for both Central and Peripheral Benzodiazepine Receptors. A New Series of High-Affinity and Selective Ligands for the Peripheral Type", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 40, 1997, pages 3109 - 3118, XP002900938, ISSN: 0022-2623
GUPTA S P ET AL: "QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP STUDIES ON SOME NONBENZODIAZEPINE SERIES OF COMPOUNDS ACTING AT THE BENZODIAZEPINE RECEPTOR", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER SCIENCE LTD, GB, vol. 6, no. 11, 1998, pages 2213 - 2218, XP000872293, ISSN: 0968-0896
LOEBER S ET AL: "Azaindole Derivatives with High Affinity for the Dopamine D4 Receptor: Synthesis, Ligand Binding Studies and Comparison of Molecular Electrostatic Potential Maps", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 9, no. 1, January 1999 (1999-01-01), pages 97 - 102, XP004154785, ISSN: 0960-894X
LOMBARDINO J G: "Preparation and new reactions of Imidazo[1,2-a]pyridines", JOURNAL OF ORGANIC CHEMISTRY, no. 7, 12 July 1965 (1965-07-12), pages 2403 - 2407, XP001055720
GUPTA S P ET AL: "QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP STUDIES ON SOME NONBENZODIAZEPINE SERIES OF COMPOUNDS ACTING AT THE BENZODIAZEPINE RECEPTOR", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER SCIENCE LTD, GB, vol. 6, no. 11, 1998, pages 2213 - 2218, XP000872293, ISSN: 0968-0896
LOEBER S ET AL: "Azaindole Derivatives with High Affinity for the Dopamine D4 Receptor: Synthesis, Ligand Binding Studies and Comparison of Molecular Electrostatic Potential Maps", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 9, no. 1, January 1999 (1999-01-01), pages 97 - 102, XP004154785, ISSN: 0960-894X
LOMBARDINO J G: "Preparation and new reactions of Imidazo[1,2-a]pyridines", JOURNAL OF ORGANIC CHEMISTRY, no. 7, 12 July 1965 (1965-07-12), pages 2403 - 2407, XP001055720
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