Title:
NOVEL BIARYL AMIDE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2019/189766
Kind Code:
A1
Abstract:
[Problem] To provide: a compound which is a muscarinic M3 receptor positive allosteric modulator, in particular, a compound having a structure represented by formula (I) or a pharmaceutically acceptable salt thereof or a solvate thereof, or crystal of a specific compound having the structure represented by formula (I); a pharmaceutical composition which is characterized by comprising, as an active ingredient, the compound or the pharmaceutically acceptable salt thereof or the solvate thereof, or the crystal of the specific compound having the structure represented by formula (I); and pharmaceutical use of the compound or the pharmaceutically acceptable salt thereof or the solvate thereof, or the crystal of the specific compound having the structure represented by formula (I), in particular, a preventive and/or therapeutic agent for diseases associated with muscarinic M3 receptors (e.g., Sjogren's syndrome, inflammatory bowel disease, micturition disorder, urine storage symptom). [Solution] Provided is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof or a solvate thereof, or crystal of a specific compound represented by formula (I).
Inventors:
OGAWA KOKI (JP)
KARIBE YUSUKE (JP)
CHIYODA KOHJI (JP)
KUDO TAKASHI (JP)
KARIBE YUSUKE (JP)
CHIYODA KOHJI (JP)
KUDO TAKASHI (JP)
Application Number:
PCT/JP2019/014009
Publication Date:
October 03, 2019
Filing Date:
March 29, 2019
Export Citation:
Assignee:
MOCHIDA PHARM CO LTD (JP)
International Classes:
C07D207/09; A61K31/437; A61K31/4439; A61K31/454; A61K31/4545; A61K31/496; A61K31/497; A61P1/02; A61P1/04; A61P1/10; A61P13/02; A61P27/02; A61P27/06; C07D401/06; C07D401/12; C07D401/14; C07D471/04
Domestic Patent References:
| WO2015186821A1 | 2015-12-10 |
Other References:
HWANG J. Y. ET AL.: "Optimization of Cloronitrobenzamides as therapeutic leads for human african trypanosomiasis", JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, no. 7, 2013, pages 2850 - 2860, XP055116160, DOI: 10.1021/jm301687p
Attorney, Agent or Firm:
HANABUSA PATENT & TRADEMARK OFFICE (JP)
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