NOVEL BICYCLIC COMPOUND OR SALT THEREOF - TAIHO PHARMACEUTICAL CO LTD

Title:

NOVEL BICYCLIC COMPOUND OR SALT THEREOF

Document Type and Number:

WIPO Patent Application WO/2012/093708

Kind Code:

A1

Abstract:

Provided is a novel bicyclic compound which is capable of inhibiting HSP90 and has a carcinostatic effect. A compound represented by general formula (I) or a salt thereof. In general formula (I): at least one of X1, X2, X3 and X4 represents N or N-oxide and the remainders are the same or different and represent C-R2; one or two of Y1, Y2, Y3 and Y4 represent C-R4 and the remainders are the same or different and represent CH or N; R1 represents an optionally substituted monocyclic or bicyclic unsaturated heterocyclic group having 1-4 hetero atoms, said hetero atoms being selected from among N, S and O; R2 represents a hydrogen atom, an optionally substituted C1-6 alkyl group, etc.; R3 represents -CO-R5, etc.; R4 represents a hydrogen atom, -N(R7)(R8), etc.; R5 represents a hydroxyl group, an amino group, etc.; and R7 and R8 are the same or different and represent a hydrogen atom, an optionally substituted C1-6 alkyl group, etc.

Inventors:

KITADE MAKOTO (JP)
YAMASHITA SATOSHI (JP)
OHKUBO SHUICHI (JP)

Application Number:

PCT/JP2012/050141

Publication Date:

July 12, 2012

Filing Date:

January 06, 2012

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Assignee:

TAIHO PHARMACEUTICAL CO LTD (JP)
KITADE MAKOTO (JP)
YAMASHITA SATOSHI (JP)
OHKUBO SHUICHI (JP)

International Classes:

C07D215/12; A61K31/4375; A61K31/4709; A61K31/4725; A61K31/497; A61K31/501; A61K31/506; A61K31/517; A61K31/5377; A61P35/00; A61P35/02; A61P43/00; C07D401/04; C07D401/14; C07D403/14; C07D405/14; C07D413/04; C07D417/04; C07D471/04

Domestic Patent References:

WO2008026704A1	2008-03-06
WO2009133136A1	2009-11-05
WO2009062289A1	2009-05-22
WO2011004610A1	2011-01-13
WO2010106290A1	2010-09-23
WO2009122034A2	2009-10-08

Foreign References:

JP2004502685A	2004-01-29
JPS57203068A	1982-12-13

Other References:

GILMAN, H. ET AL.: "Some substituted isoquinolines", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 69, 1947, pages 1946 - 1948, XP055118250

Attorney, Agent or Firm:

THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
Patent business corporation Alga patent firm (JP)

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