Title:
NOVEL BICYCLIC HETEROARYL COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/014885
Kind Code:
A1
Abstract:
The present invention provides a novel compound represented by chemical formula 1, an optical isomer thereof, or a pharmaceutically acceptable salt thereof. With an excellent inhibitory activity against PIKfyve, the novel compound of the present invention is useful as a therapeutic agent for PIKfyve activity-related cancer disease, inflammatory disease, or lysosomal storage disease.
Inventors:
PARK SUNYOUNG (KR)
SONG HYOJUNG (KR)
JANG KYUSIC (KR)
CHANG MIN WHAN (KR)
KIM MINKYUNG (KR)
JEONG IL JI (KR)
LIM JONGHA (KR)
YOO JISU (KR)
JEON WOOJIN (KR)
SONG YOONSUNG (KR)
YOON HONG CHUL (KR)
PARK JOON TAE (KR)
LEE JUNG WOO (KR)
AN KYUNG MI (KR)
PARK DONGSIK (KR)
KIM DASOL (KR)
IM WEONBIN (KR)
EUN SO-YOUNG (KR)
MIN BYONG-KEOL (KR)
LEE HONG JAE (KR)
KIM EUNJUNG (KR)
PARK EOK (KR)
SONG HYOJUNG (KR)
JANG KYUSIC (KR)
CHANG MIN WHAN (KR)
KIM MINKYUNG (KR)
JEONG IL JI (KR)
LIM JONGHA (KR)
YOO JISU (KR)
JEON WOOJIN (KR)
SONG YOONSUNG (KR)
YOON HONG CHUL (KR)
PARK JOON TAE (KR)
LEE JUNG WOO (KR)
AN KYUNG MI (KR)
PARK DONGSIK (KR)
KIM DASOL (KR)
IM WEONBIN (KR)
EUN SO-YOUNG (KR)
MIN BYONG-KEOL (KR)
LEE HONG JAE (KR)
KIM EUNJUNG (KR)
PARK EOK (KR)
Application Number:
PCT/KR2023/009985
Publication Date:
January 18, 2024
Filing Date:
July 12, 2023
Export Citation:
Assignee:
ILDONG PHARMACEUTICAL CO LTD (KR)
ARBORMED CO LTD (KR)
ARBORMED CO LTD (KR)
International Classes:
C07D487/04; A61K31/52; A61K31/5377; A61P25/00; A61P29/00; A61P35/00; C07D401/04; C07D471/04; C07D473/00; C07D473/34
Domestic Patent References:
| WO2021146192A1 | 2021-07-22 | |||
| WO2009023978A1 | 2009-02-26 |
Foreign References:
| CN110256436A | 2019-09-20 |
Other References:
LINK, W ET AL.: "Chemical Interrogation of FOXO3a Nuclear Translocation Identifies Potent and Selective Inhibitors of Phosphoinositide 3-Kinases", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 284, no. 41, 2009, pages 28392 - 28400, XP002620422, DOI: 10.1074/JBC.M109.038984
MA, J. -G. ET AL.: "PH 006, a novel and selective Src kinase inhibitor, suppresses human breast cancer growth and metastasis in vitro and in vivo", BREAST CANCER RESEARCH AND TREATMENT, vol. 130, no. 1, 2011, pages 85 - 96, XP019958066, DOI: 10.1007/s10549-010-1302-4
MA, J. -G. ET AL.: "PH 006, a novel and selective Src kinase inhibitor, suppresses human breast cancer growth and metastasis in vitro and in vivo", BREAST CANCER RESEARCH AND TREATMENT, vol. 130, no. 1, 2011, pages 85 - 96, XP019958066, DOI: 10.1007/s10549-010-1302-4
Attorney, Agent or Firm:
KIM, Kyeongkyo et al. (KR)
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