Title:
NOVEL BICYCLIC HYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE
Document Type and Number:
WIPO Patent Application WO2003066579
Kind Code:
A3
Abstract:
The present invention is directed to certain bicyclic hydroxamate derivatives that are inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical compositions and processes for preparing these compounds are also disclosed
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Inventors:
LEAHY ELLEN M (US)
VERNER ERIK J (US)
VERNER ERIK J (US)
Application Number:
PCT/US2003/003846
Publication Date:
October 30, 2003
Filing Date:
February 07, 2003
Export Citation:
Assignee:
AXYS PHARMACEUTICALS (US)
LEAHY ELLEN M (US)
VERNER ERIK J (US)
LEAHY ELLEN M (US)
VERNER ERIK J (US)
International Classes:
C07D295/18; A61K31/166; A61K31/167; A61K31/18; A61K31/40; A61K31/404; A61K31/4045; A61K31/4164; A61K31/4184; A61K31/4406; A61K31/4409; A61K31/4453; A61K31/495; A61K31/5375; A61K45/00; A61P25/14; A61P35/00; A61P43/00; C07C259/10; C07C275/42; C07C311/08; C07C311/13; C07C311/21; C07C311/29; C07D207/16; C07D209/14; C07D209/18; C07D209/42; C07D211/10; C07D211/16; C07D211/22; C07D211/30; C07D211/46; C07D211/60; C07D211/62; C07D213/38; C07D213/56; C07D213/65; C07D213/81; C07D213/82; C07D233/54; C07D233/64; C07D235/18; C07D295/108; C07D295/135; C07D307/24; C07D307/68; C07D317/58; C07D317/60; C07D317/68; C07D333/24; C07D333/38; C07D401/12; C07D405/12; C12Q1/34; C12Q1/37; C12Q1/48; (IPC1-7): C07C259/10; A61K31/16; A61K31/18; A61K31/425; A61P35/00; C07C275/42; C07C311/21; C07D207/16; C07D209/14; C07D209/18; C07D211/22; C07D211/46; C07D211/60; C07D213/38; C07D213/56; C07D213/65; C07D213/81; C07D213/82; C07D233/64; C07D235/18; C07D295/14; C07D295/18; C07D317/58; C07D317/60; C07D317/68; C07D333/24; C07D333/38; C07D405/12
Domestic Patent References:
| WO2001070675A2 | 2001-09-27 |
Foreign References:
| EP1078917A1 | 2001-02-28 | |||
| EP0067511A2 | 1982-12-22 | |||
| US3903083A | 1975-09-02 |
Other References:
PYRIADI T M ET AL: "ANIONIC RING-OPENING POLYMERIZATION OF SEVERAL N-SUBSTITUTED DIPHENIMIDES", JOURNAL OF POLYMER SCIENCE, POLYMER CHEMISTRY EDITION, JOHN WILEY AND SONS. NEW YORK, US, vol. 31, no. 13, 1 December 1993 (1993-12-01), pages 3199 - 3203, XP000415132, ISSN: 0360-6376
FOKS H ET AL: "STUDIES ON PYRAZINE DERIVATIVES PART X. SYNTHESIS AND TUBERCULOSTATIC ACTIVITY OF SOME 6-CYCLAMINO-6-IMIDAZOLYL- AND TRIAZOLYLPYRAZINE-2CARBOXYLIC ACIDS DERIVATIVES", POLISH JOURNAL OF PHARMACOLOGY AND PHARMACY, POLISH ACADEMY OF SCIENCES INSTITUTE OF, PL, vol. 30, no. 1, 1978, pages 105 - 111, XP008016993, ISSN: 0301-0244
THUNUS, L. ET AL: "(4-Methyl-1-piperazinyl) pyridine dimethylsulfonamide derivatives", ANNALES PHARMACEUTIQUES FRANCAISES ( 1974 ), 32(11), 569-74, XP008020035
FOKS H ET AL: "STUDIES ON PYRAZINE DERIVATIVES PART X. SYNTHESIS AND TUBERCULOSTATIC ACTIVITY OF SOME 6-CYCLAMINO-6-IMIDAZOLYL- AND TRIAZOLYLPYRAZINE-2CARBOXYLIC ACIDS DERIVATIVES", POLISH JOURNAL OF PHARMACOLOGY AND PHARMACY, POLISH ACADEMY OF SCIENCES INSTITUTE OF, PL, vol. 30, no. 1, 1978, pages 105 - 111, XP008016993, ISSN: 0301-0244
THUNUS, L. ET AL: "(4-Methyl-1-piperazinyl) pyridine dimethylsulfonamide derivatives", ANNALES PHARMACEUTIQUES FRANCAISES ( 1974 ), 32(11), 569-74, XP008020035
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