Title:
NOVEL BIFIDOBACTERIUM BIFIDUM STRAIN AND STRAIN-DERIVED POLYSACCHARIDE
Document Type and Number:
WIPO Patent Application WO/2018/230960
Kind Code:
A3
Abstract:
The present invention relates to a Bifidobacterium bifidum inducing regulatory T cells (Treg), a polysaccharide derived from Bifidobacterium bifidum, and a probiotic strain producing a polysaccharide and, more particularly, a polysaccharide containing β-1-6-glucan as an effective ingredient, a probiotic strain producing β-1-6-glucan, a food comprising the polysaccharide or strain as an effective ingredient for alleviation of immune disease or inflammatory disease, a therapeutic agent comprising the polysaccharide or strain as an effective ingredient for alleviation of immune disease or inflammatory disease, a method for preparing induced regulatory T cells (iTreg) by treatment with the polysaccharide or strain, and a cell therapy product for prevention or treatment of immune disease or inflammatory disease, comprising the induced regulatory T cells prepared by the method.
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Inventors:
IM SIN-HYEOG (KR)
VERMA RAVI (KR)
LEE CHANGHON (KR)
VERMA RAVI (KR)
LEE CHANGHON (KR)
Application Number:
PCT/KR2018/006700
Publication Date:
March 28, 2019
Filing Date:
June 14, 2018
Export Citation:
Assignee:
INST BASIC SCIENCE (KR)
POSTECH ACAD IND FOUND (KR)
POSTECH ACAD IND FOUND (KR)
International Classes:
C12N1/20; A23L33/135; A61K31/716; A61K35/745; C08B37/00; C12N5/0783
Foreign References:
| US20150152454A1 | 2015-06-04 | |||
| EP1965809B1 | 2009-09-09 | |||
| US20170081428A1 | 2017-03-23 |
Other References:
SASSAKI, GUILHERME L.: "Pustulan and branched beta-gatactofuranan from the phytopathogenic fungus Guignardia citricarpa, excreted from media containing glucose and sucrose", CARBOHYDRATE POLYMERS, vol. 48, no. 4, June 2002 (2002-06-01), pages 385 - 389, XP004339327, ISSN: 0144-8617, DOI: 10.1016/S0144-8617(01)00286-7
LOPEZ ET AL.: "Immune response to Bifidobacterium bifidum strains support Treg/Th17 plasticityen", PLOS ONE, vol. 6, no. 9, 22 September 2011 (2011-09-22), pages e24776, XP055584689
IM, SIN-HYEOG: "Reprogramming of the immune system by rationally selected probiotics", UNIST-LIFE SCIENCES, 7 June 2018 (2018-06-07), BLDG 110 Room N104, XP055584695, Retrieved from the Internet
LOPEZ ET AL.: "Immune response to Bifidobacterium bifidum strains support Treg/Th17 plasticityen", PLOS ONE, vol. 6, no. 9, 22 September 2011 (2011-09-22), pages e24776, XP055584689
IM, SIN-HYEOG: "Reprogramming of the immune system by rationally selected probiotics", UNIST-LIFE SCIENCES, 7 June 2018 (2018-06-07), BLDG 110 Room N104, XP055584695, Retrieved from the Internet
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
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