Title:
NOVEL BIFIDOBACTERIUM LONGUM OR LACTOBACILLUS RHAMNOSUS STRAIN HAVING EFFECT OF PREVENTING OR TREATING OBESITY, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/199094
Kind Code:
A1
Abstract:
The present invention relates to a novel Bifidobacterium longum or Lactobacillus rhamnosus strain having an effect of preventing or treating obesity, and a use thereof. Treatment of each of the lactic acid bacteria strains of Bifidobacterium longum and Lactobacillus rhamnosus, of the present invention, causes browning of white adipocytes and, particularly, it has been confirmed that beige adipocyte- and brown adipocyte-specific gene expression significantly increases over that of an untreated control group. In addition, as a result of experimentation on high fat diet-induced obese mice is carried out, each strain exhibits a weight gain inhibitory effect more significant than that of a negative control group, and an effect of increased expression of a thermogenesis-specific gene, in the white adipocytes of the mice, has been confirmed. Therefore, each of the lactic acid bacteria strains of Bifidobacterium longum and Lactobacillus rhamnosus exhibits an anti-obesity effect so as to be effectively usable as a food, a drug or a feed for preventing or treating obesity, thereby being very useful in related industries.
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Inventors:
KIM YONG SIK (KR)
PARK DOO SANG (KR)
SON MI YOUNG (KR)
KI SOO JIN (KR)
KIM JI SUN (KR)
OH HYUN WOO (KR)
LEE YU RI (KR)
JEON JUN HYOUNG (KR)
JEONG SEON A (KR)
PARK DOO SANG (KR)
SON MI YOUNG (KR)
KI SOO JIN (KR)
KIM JI SUN (KR)
OH HYUN WOO (KR)
LEE YU RI (KR)
JEON JUN HYOUNG (KR)
JEONG SEON A (KR)
Application Number:
PCT/KR2019/004395
Publication Date:
October 17, 2019
Filing Date:
April 11, 2019
Export Citation:
Assignee:
KOREA RES INST BIOSCIENCE & BIOTECHNOLOGY (KR)
UNIV SOONCHUNHYANG IND ACAD COOP FOUND (KR)
UNIV SOONCHUNHYANG IND ACAD COOP FOUND (KR)
International Classes:
A61K35/744; A23K10/16; A23L33/135; A61K35/745; A61K35/747; A61P3/04
Domestic Patent References:
| WO2008116700A1 | 2008-10-02 |
Foreign References:
| KR101709246B1 | 2017-02-22 | |||
| KR20150118084A | 2015-10-21 |
Other References:
BORGERAAS, H. ET AL.: "Effects of probiotics on body weight, body mass index, fat mass and fat percentage 4in subjects with overweight or obesity: a systematic review and meta-analysis of randomized controlled trials", OBESITY REVIEWS, vol. 19, no. 2, 18 October 2017 (2017-10-18) - February 2018 (2018-02-01), pages 219 - 232
KOBYLIAK, N. ET AL.: "Probiotics in prevention and treatment of obesity: a critical view", NUTRITION & METABOLISM, vol. 13, 2016, pages 1 - 13, XP055429690, DOI: 10.1186/s12986-016-0067-0
HOSSAIN, M. ET AL.: "The effect of Bifidobacterium longum DS0956 in the browning through activation of thermogenic genes' expression", KMB 2018, 27 June 2018 (2018-06-27), Korea
KOBYLIAK, N. ET AL.: "Probiotics in prevention and treatment of obesity: a critical view", NUTRITION & METABOLISM, vol. 13, 2016, pages 1 - 13, XP055429690, DOI: 10.1186/s12986-016-0067-0
HOSSAIN, M. ET AL.: "The effect of Bifidobacterium longum DS0956 in the browning through activation of thermogenic genes' expression", KMB 2018, 27 June 2018 (2018-06-27), Korea
Attorney, Agent or Firm:
BAE, KIM & LEE IP GROUP (KR)
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