Title:
NOVEL BIOMARKER FOR CANCER IMMUNOTHERAPY
Document Type and Number:
WIPO Patent Application WO/2018/168949
Kind Code:
A1
Abstract:
The present invention provides a technique for predicting a responder prior to beginning cancer immunotherapy. The present invention provides a method for using the T cell receptor (TCR) diversity of a subject as an indicator of the responsiveness of the subject to cancer immunotherapy. The present invention also provides a composition including an immune checkpoint inhibitor, wherein the composition is for treating cancer in a subject having high TCR diversity of the T cells. The present invention also pertains to a companion drug in which such TCR diversity is used.
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Inventors:
MATSUMOTO SEIJI (JP)
SUZUKI RYUJI (JP)
SUZUKI RYUJI (JP)
Application Number:
PCT/JP2018/010028
Publication Date:
September 20, 2018
Filing Date:
March 14, 2018
Export Citation:
Assignee:
HYOGO COLLEGE MEDICINE (JP)
REPERTOIRE GENESIS INC (JP)
REPERTOIRE GENESIS INC (JP)
International Classes:
C12Q1/02; A61K39/395; A61K45/00; A61P35/00; A61P37/02; G01N33/53
Domestic Patent References:
| WO2015162596A1 | 2015-10-29 | |||
| WO2015075939A1 | 2015-05-28 |
Foreign References:
| JP2015536642A | 2015-12-24 | |||
| JP2016531849A | 2016-10-13 |
Other References:
KITAURA, KAZUTAKA ET AL.,: "Evaluation of effectiveness in cancer treatment by analysis of next generation TCR/BCR repertoire", BIO CLINICA, vol. 30, no. 3, 10 March 2015 (2015-03-10), pages 68 - 74, XP9515616
PARDOLL DM: "The blockade of immune checkpoints in cancer immunotherapy", NAT REV CANCER, vol. 12, no. 4, 22 March 2012 (2012-03-22), pages 252 - 64, XP055339916, DOI: 10.1038/nrc3239
OKAZAKI, T.CHIKUMA, S.IWAI, Y ET AL.: "A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application", NAT. IMMUNOL., vol. 14, 2013, pages 1212 - 1218
BUTTE, M. J.KEIR, M. E.PHAMDUY, T. B. ET AL., PD-LL INTERACTS SPECIFICALLY WITH B7-1 TO INHIBIT T CELL PROLIFERATION. IMMUNITY, vol. 27, 2007, pages 111 - 122
CELL, vol. 76, 1994, pages 287 - 299
ANNUAL REVIEW IMMUNOLOGY, vol. 6, 1993, pages 309 - 326
JOURNAL OF IMMUNOLOGICAL METHODS, vol. 169, 1994, pages 17 - 23
JOURNAL OF IMMUNOLOGICAL METHODS, vol. 201, 1997, pages 145 - 15
HUMAN IMMUNOLOGY, vol. 56, 1997, pages 57 - 69
See also references of EP 3597766A4
PARDOLL DM: "The blockade of immune checkpoints in cancer immunotherapy", NAT REV CANCER, vol. 12, no. 4, 22 March 2012 (2012-03-22), pages 252 - 64, XP055339916, DOI: 10.1038/nrc3239
OKAZAKI, T.CHIKUMA, S.IWAI, Y ET AL.: "A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application", NAT. IMMUNOL., vol. 14, 2013, pages 1212 - 1218
BUTTE, M. J.KEIR, M. E.PHAMDUY, T. B. ET AL., PD-LL INTERACTS SPECIFICALLY WITH B7-1 TO INHIBIT T CELL PROLIFERATION. IMMUNITY, vol. 27, 2007, pages 111 - 122
CELL, vol. 76, 1994, pages 287 - 299
ANNUAL REVIEW IMMUNOLOGY, vol. 6, 1993, pages 309 - 326
JOURNAL OF IMMUNOLOGICAL METHODS, vol. 169, 1994, pages 17 - 23
JOURNAL OF IMMUNOLOGICAL METHODS, vol. 201, 1997, pages 145 - 15
HUMAN IMMUNOLOGY, vol. 56, 1997, pages 57 - 69
See also references of EP 3597766A4
Attorney, Agent or Firm:
YAMAMOTO Shusaku et al. (JP)
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