Title:
NOVEL BIOTIN-SPECIFIC MONOCLONAL ANTIBODY AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/122205
Kind Code:
A3
Abstract:
The present invention relates to a monoclonal antibody capable of binding to biotin. In one embodiment the monoclonal antibody according to the invention also does not bind to a biotin moiety on a biotinylated molecule, wherein the biotin moiety is attached to the molecule via the carbon atom of the carboxyl function of the valeric acid moiety of biotin. Also disclosed is a method for generation of an antibody as discloed herein. The monoclonal antibody according to the invention is of specific use in a method for measuring an analyte in a sample, wherein a (strept)avidin/biotin pair is used to bind a biotinylated analyte specific binding agent to a (strept)avidin coated solid phase.
Inventors:
GERG MICHAEL (DE)
HEINDL DIETER (DE)
HILLRINGHAUS LARS (DE)
HIRZEL KLAUS (DE)
HOJER CAROLINE DOROTHEA (DE)
HUBER FLORIAN (DE)
JOSEL HANS-PETER (DE)
MEIER THOMAS (DE)
SCHRAEML MICHAEL (DE)
VOSS EDGAR (DE)
HEINDL DIETER (DE)
HILLRINGHAUS LARS (DE)
HIRZEL KLAUS (DE)
HOJER CAROLINE DOROTHEA (DE)
HUBER FLORIAN (DE)
JOSEL HANS-PETER (DE)
MEIER THOMAS (DE)
SCHRAEML MICHAEL (DE)
VOSS EDGAR (DE)
Application Number:
PCT/EP2017/084541
Publication Date:
August 09, 2018
Filing Date:
December 22, 2017
Export Citation:
Assignee:
HOFFMANN LA ROCHE (CH)
ROCHE DIAGNOSTICS GMBH (DE)
ROCHE DIAGNOSTICS OPERATIONS INC (US)
ROCHE DIAGNOSTICS GMBH (DE)
ROCHE DIAGNOSTICS OPERATIONS INC (US)
International Classes:
C07K16/44; A61K31/4188; A61K47/51; C07D495/04; C07K16/00; C07K16/40; G01N33/53; G01N33/82
Domestic Patent References:
| WO2000050088A2 | 2000-08-31 |
Foreign References:
| EP0371262A1 | 1990-06-06 | |||
| JP2008094721A | 2008-04-24 | |||
| US20010016343A1 | 2001-08-23 |
Other References:
HARVEY E. INDYK ET AL: "Biotin content of paediatric formulae, early lactation milk and seasonal bovine milk powders by biosensor immunoassay", INTERNATIONAL DAIRY JOURNAL, vol. 35, no. 1, 1 March 2014 (2014-03-01), GB, pages 25 - 31, XP055346243, ISSN: 0958-6946, DOI: 10.1016/j.idairyj.2013.10.002
LATISHA C JOHNSON: "The synthesis of new biotin derivatives and their bioactivity", 1 December 2002 (2002-12-01), XP055346535, Retrieved from the Internet
1 January 1986, CONDENSED IMIDAZOLES, JOHN WILES & SONS, NEW YOORK CHISTER BRISBANE TORONT SINGAPORE, PAGE(S) 198 - 199, ISBN: 0-471-88384-0, article PRESTON, XP002767342
WU F B ET AL: "Matrix interference in serum total thyroxin (T4) time-resolved fluorescence immunoassay (TRFIA) and its elimination with the use of streptavidin-biotin separation technique", CLINICA CHIMICA ACTA, ELSEVIER BV, AMSTERDAM, NL, vol. 308, no. 1-2, 1 June 2001 (2001-06-01), pages 117 - 126, XP027214145, ISSN: 0009-8981, [retrieved on 20010601]
DAKSHINAMURTI ET AL: "Production and characterization of a monoclonal antibody to biotin.", BIOCHEMICAL JOURNAL, vol. 237, no. 2, 1 July 1986 (1986-07-01), pages 477 - 482, XP055040137, ISSN: 0264-6021, DOI: 10.1042/bj2370477
KOHEN F ET AL: "PREPARATION AND PROPERTIES OF ANTI-BIOTIN ANTIBODIES", METHODS IN ENZYMOLOGY, ACADEMIC PRESS, US, vol. 279, 1 January 1997 (1997-01-01), pages 451 - 463, XP001029297, ISSN: 0076-6879, DOI: 10.1016/S0076-6879(97)79049-9
LATISHA C JOHNSON: "The synthesis of new biotin derivatives and their bioactivity", 1 December 2002 (2002-12-01), XP055346535, Retrieved from the Internet
1 January 1986, CONDENSED IMIDAZOLES, JOHN WILES & SONS, NEW YOORK CHISTER BRISBANE TORONT SINGAPORE, PAGE(S) 198 - 199, ISBN: 0-471-88384-0, article PRESTON, XP002767342
WU F B ET AL: "Matrix interference in serum total thyroxin (T4) time-resolved fluorescence immunoassay (TRFIA) and its elimination with the use of streptavidin-biotin separation technique", CLINICA CHIMICA ACTA, ELSEVIER BV, AMSTERDAM, NL, vol. 308, no. 1-2, 1 June 2001 (2001-06-01), pages 117 - 126, XP027214145, ISSN: 0009-8981, [retrieved on 20010601]
DAKSHINAMURTI ET AL: "Production and characterization of a monoclonal antibody to biotin.", BIOCHEMICAL JOURNAL, vol. 237, no. 2, 1 July 1986 (1986-07-01), pages 477 - 482, XP055040137, ISSN: 0264-6021, DOI: 10.1042/bj2370477
KOHEN F ET AL: "PREPARATION AND PROPERTIES OF ANTI-BIOTIN ANTIBODIES", METHODS IN ENZYMOLOGY, ACADEMIC PRESS, US, vol. 279, 1 January 1997 (1997-01-01), pages 451 - 463, XP001029297, ISSN: 0076-6879, DOI: 10.1016/S0076-6879(97)79049-9
Attorney, Agent or Firm:
MISERA, Simon et al. (DE)
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