NOVEL BIPHENYL COMPOUND OR SALT THEREOF - TAIHO PHARMACEUTICAL CO LTD

Title:

NOVEL BIPHENYL COMPOUND OR SALT THEREOF

Document Type and Number:

WIPO Patent Application WO/2018/216800

Kind Code:

A1

Abstract:

The present invention provides: a compound represented by general formula (I) or a salt thereof; an LSD1 inhibitor which contains the compound or a salt thereof as an active ingredient; a pharmaceutical composition which contains the compound or a salt thereof; and an antitumor agent which contains the compound or a salt thereof as an active ingredient.

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Inventors:

YAMASHITA SATOSHI (JP)
OGAWA TAKAHIRO (JP)

Application Number:

PCT/JP2018/020158

Publication Date:

November 29, 2018

Filing Date:

May 25, 2018

Export Citation:

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Assignee:

TAIHO PHARMACEUTICAL CO LTD (JP)

International Classes:

C07D207/14; A61K31/40; A61K31/407; A61K31/416; A61K31/4184; A61K31/4192; A61K31/423; A61K31/437; A61K31/438; A61K31/439; A61K31/445; A61K31/4709; A61K31/4725; A61K31/496; A61K31/498; A61K31/502; A61K31/517; A61K31/537; A61K31/551; A61P35/00; A61P35/02; A61P43/00; C07D211/56; C07D211/58; C07D223/12; C07D243/08; C07D295/192; C07D401/10; C07D403/10; C07D405/10; C07D413/10; C07D417/10; C07D471/04; C07D471/08; C07D471/10; C07D487/04; C07D487/08; C07D487/10; C07D498/10; C07D519/00

Domestic Patent References:

WO2016037005A1	2016-03-10
WO2016007727A1	2016-01-14
WO2017090756A1	2017-06-01
WO2015089192A1	2015-06-18
WO2015168466A1	2015-11-05
WO2012135113A2	2012-10-04

Other References:

WU, F. ET AL.: "3-(Piperidin-4-ylmethoxy)pyridine Containing Compounds Are Potent Inhibitors of Lysine Specific Demethylase 1", JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, no. 1, 14 January 2016 (2016-01-14), pages 253 - 263, XP055440785
BIOCHIM. BIOPHYS. ACTA, vol. 1829, no. 10, 2013, pages 981 - 986
EPIGENOMICS, vol. 7, no. 4, 2015, pages 609 - 626
CANCER CELL, vol. 21, no. 4, 2012, pages 473 - 487
CANCER CELL, vol. 28, no. 1, 2015, pages 57 - 69
SCI. TRANSL. MED., vol. 6, no. 265, 2014, pages 265ra169
NAT. MED., vol. 19, no. 3, 2013, pages 291 - 294
T.W. GREEN: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS
See also references of EP 3632897A4

Attorney, Agent or Firm:

SAEGUSA & PARTNERS (JP)

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