Title:
NOVEL BIPHENYL AND PHENYL-PYRIDINE AMIDES
Document Type and Number:
WIPO Patent Application WO/2010/149578
Kind Code:
A3
Abstract:
Compounds of the formula (I) or a pharmaceutically acceptable salt thereof, wherein, R1, R2, R3, R4, R5, R6, R7, and R8 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.
Inventors:
BROKA CHRIS ALLEN (US)
HAWLEY RONALD CHARLES (US)
HAWLEY RONALD CHARLES (US)
Application Number:
PCT/EP2010/058611
Publication Date:
July 14, 2011
Filing Date:
June 18, 2010
Export Citation:
Assignee:
HOFFMANN LA ROCHE (CH)
BROKA CHRIS ALLEN (US)
HAWLEY RONALD CHARLES (US)
BROKA CHRIS ALLEN (US)
HAWLEY RONALD CHARLES (US)
International Classes:
C07C237/42; A61K31/166; A61K31/33; C07D213/00; C07D231/00; C07D233/00; C07D241/00; C07D261/00; C07D263/00; C07D265/00; C07D277/00; C07D285/00; C07D305/00; C07D307/00; C07D309/00; C07D333/00
Domestic Patent References:
| WO2009058298A1 | 2009-05-07 | |||
| WO2003066579A2 | 2003-08-14 | |||
| WO2010030592A1 | 2010-03-18 |
Foreign References:
| US20080004442A1 | 2008-01-03 |
Other References:
KASSACK M U ET AL: "Structure-activity relationships of analogues of NF449 confirm NF449 as the most potent and selective known P2X1 receptor antagonist", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 39, no. 4, 1 April 2004 (2004-04-01), pages 345 - 357, XP004502469, ISSN: 0223-5234, DOI: DOI:10.1016/J.EJMECH.2004.01.007
Attorney, Agent or Firm:
SAUER, Frank (Basel, CH)
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