Title:
NOVEL BIS-AMIDE DERIVATIVE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/037892
Kind Code:
A1
Abstract:
The present invention relates to: a novel bis-amide derivative compound or a pharmaceutically acceptable salt thereof; a preparation method therefor; and a pharmaceutical composition for preventing or treating diseases caused by hepatitis C virus infection and a dietary supplement for preventing or alleviating diseases caused by hepatitis C virus infection, containing the bis-amide derivative compound or a pharmaceutically acceptable salt thereof as an active ingredient. The novel bis-amide derivative compound of the present invention, particularly WJCPA-126, specifically binds to the catalytic site of CypA to effectively inhibit the activity of an isomerase, and the duration of the inhibitory effect can be increased since WJCPA-126 binds to CypA with a high binding force exhibiting a low dissociation rate (Koff). Accordingly, WJCPA-126 has nontoxic and non-immunosuppressive characteristics and can effectively inhibit HCV replication in vitro and in vivo model systems. In addition, WJCPA-126 reactivates the host interferon response through an increase in the expression of IFN stimulated genes (ISGs) and the inhibition of interleukin-8 (IL-8) secretion. Therefore, a series of the bis-amide derivatives including WJCPA-126 can be useful as a novel type CypA inhibitor exhibiting antiviral efficacy.
Inventors:
KIM SUNG SOO (KR)
CHO WON JEA (KR)
CHO WON JEA (KR)
Application Number:
PCT/KR2014/008402
Publication Date:
March 19, 2015
Filing Date:
September 05, 2014
Export Citation:
Assignee:
UNIV KYUNG HEE UNIV IND COOP GROUP (KR)
International Classes:
A61K31/16; C07C233/05; A61P31/12
Domestic Patent References:
| WO2009150248A1 | 2009-12-17 | |||
| WO2012129452A2 | 2012-09-27 |
Other References:
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AMIT KUMAR ET AL.: "A expedient route to imidazo[1,4]diazepin-7-ones via a post-Ugi gold-catalyzed heteroannulation", ORGANIC LETTERS, vol. 15, no. 8, 19 April 2013 (2013-04-19), pages 1874 - 1877, XP055328863
AMIT KUMAR ET AL.: "Gold(I)-catalyzed post-Ugi hydroarylation'' an approach to pyrrolepyridines and azepinoindoles", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, no. ISSUE, April 2013 (2013-04-01), pages 2288 - 2292, XP055328865
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AMIT KUMAR ET AL.: "A expedient route to imidazo[1,4]diazepin-7-ones via a post-Ugi gold-catalyzed heteroannulation", ORGANIC LETTERS, vol. 15, no. 8, 19 April 2013 (2013-04-19), pages 1874 - 1877, XP055328863
AMIT KUMAR ET AL.: "Gold(I)-catalyzed post-Ugi hydroarylation'' an approach to pyrrolepyridines and azepinoindoles", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, no. ISSUE, April 2013 (2013-04-01), pages 2288 - 2292, XP055328865
DIPAK D. VACHHANI ET AL.: "Diversely substituted triazolo[1,5-a][1,4]benzo- diazepinones: A post-Ugi copper-catalyzed tandem azide-alkyne cycloaddition/ullmann C- N coupling approach", EUROPEAN JOURNAL OF ORGAINIC CHEMISTRY, no. ISSUE, March 2013 (2013-03-01), pages 1223 - 1227, XP055328867
P. PRAMITHA ET AL.: "Stereoselective synthesis of bio-hybrid amphiphiles of coumarin derivatives by Ugi-Mannich triazole randomization using copper catalyzed''.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 22, 9 February 2012 (2012-02-09), pages 2598 - 2603, XP028471773
Attorney, Agent or Firm:
SON, MIN (KR)
손민 (KR)
손민 (KR)
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