Title:
NOVEL BISPECIFIC BINDING MOLECULE AND DRUG CONJUGATE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/177717
Kind Code:
A1
Abstract:
The present invention provides a novel bispecific binding molecule and use thereof. The novel bispecific binding molecule-drug conjugate of the present invention comprises: a) a bispecific binding molecule consisting of a first binding part bound to a tumor cell surface antigen (T) and a second antigen binding domain bound to the internalization effect albumen (E), b) a cytotoxic component covalently coupled to the bispecific binding molecule. The bispecific binding molecule may specifically exert cytotoxic activity against tumor cells by specifically targeting to the tumor cells through the first antigen binding domain, and internalizing the cytotoxic component into the tumor cells by the second antigen binding domain of the bispecific binding molecule.
Inventors:
WANG FENG (CN)
ZHENG HUAYANG (CN)
ZHANG YUHAN (CN)
ZHENG HUAYANG (CN)
ZHANG YUHAN (CN)
Application Number:
PCT/CN2020/077793
Publication Date:
September 10, 2020
Filing Date:
March 04, 2020
Export Citation:
Assignee:
SHANGHAI YICHEN BIOMED CO LTD (CN)
International Classes:
A61K47/68; C07K16/28; A61P35/00; C07K16/32; C07K19/00
Domestic Patent References:
| WO2019028125A1 | 2019-02-07 | |||
| WO2017185662A1 | 2017-11-02 |
Foreign References:
| CN107849131A | 2018-03-27 | |||
| CN109071658A | 2018-12-21 | |||
| CN105073781A | 2015-11-18 | |||
| CN104302664A | 2015-01-21 | |||
| CN105814082A | 2016-07-27 |
Other References:
HUANG, YAOXING ET AL.: "Engineered Bispecific Antibodies with Exquisite HIV-1-Neutralizinj Activity", CELL, vol. 165, no. 7, 16 June 2016 (2016-06-16), pages 1621 - 1631, XP029612948, DOI: 10.1016/j.cell.2016.05.024
Attorney, Agent or Firm:
WU, FENG & ZHANG (CN)
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