Title:
NOVEL BONE MASS INCREASING AGENT
Document Type and Number:
WIPO Patent Application WO/2008/150025
Kind Code:
A1
Abstract:
Disclosed is a bone formation enhancing agent comprising an RANKL-acting molecule
which can enhance the differentiation, maturation or calcification of an osteoblast
or a cell capable of being differentiated into an osteoblast. Specifically
disclosed is a pharmaceutical composition for the treatment or prevention of
a metabolic bone disease accompanied by the decrease in bone mass, which comprises,
as an active ingredient, a compound which can act on an RANKL located on an osteoblast
or a cell capable of being differentiated into an osteoblast to accelerate the
differentiation, proliferation, maturation or calcification of the osteoblast
or the cell capable of being differentiated into an osteoblast.
Inventors:
YASUDA HISATAKA (JP)
FURUYA YURIKO (JP)
TAGUCHI YUSUKE (JP)
FURUYA YURIKO (JP)
TAGUCHI YUSUKE (JP)
Application Number:
PCT/JP2008/060731
Publication Date:
December 11, 2008
Filing Date:
June 05, 2008
Export Citation:
Assignee:
ORIENTAL YEAST CO LTD (JP)
YASUDA HISATAKA (JP)
FURUYA YURIKO (JP)
TAGUCHI YUSUKE (JP)
YASUDA HISATAKA (JP)
FURUYA YURIKO (JP)
TAGUCHI YUSUKE (JP)
International Classes:
A61K45/00; A61K38/00; A61P19/02; A61P19/08; A61P19/10; C07K14/705; C12Q1/02; G01N33/15; G01N33/50
Domestic Patent References:
| WO2001008677A1 | 2001-02-08 | |||
| WO2001083525A2 | 2001-11-08 | |||
| WO1998046644A1 | 1998-10-22 |
Foreign References:
| JP2003512011A | 2003-04-02 | |||
| JP2003533187A | 2003-11-11 | |||
| JP2002509430A | 2002-03-26 | |||
| JP3523650B2 | 2004-04-26 |
Other References:
HIGUCHI C. ET AL.: "Hone Keisei Inshi (BMP)", JAPANESE JOURNAL OF CLINICAL MEDICINE, vol. 62, no. SUPPL. 2, 2004, pages 52 - 56
HODA N.: "OPG", JOURNAL OF OSTEOPOROTIC MEDICINE, vol. 2, no. 3, 2003, pages 213 - 218
HODA N.: "OPG Seizai. Ko-RANKL Kotai", JAPANESE JOURNAL OF CLINICAL MEDICINE, vol. 63, no. 9, 2005, pages 1647 - 1653
AOKI K. ET AL.: "A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone loss", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 116, no. 6, 2006, pages 1525 - 1534, XP008126832
KOSTENUIK PJ, CURRENT OPINION IN PHARMACOLOGY, vol. 5, 2005, pages 618 - 625
MCLNTYRE JA; MARTIN L, DRUGS OF THE FUTURE, vol. 30, no. 3, 2005, pages 237 - 239
SUDA ET AL., ENDOCR REV, vol. 13, 1992, pages 66
SAMBOOK ET AL., N ENGL J MED, vol. 328, 1993, pages 1747
LUCKMAN ET AL., J BONE MINER RES, vol. 13, 1998, pages 581
WHYTE ET AL., N ENGL J MED, vol. 349, 2003, pages 457
ODVINA ET AL., J CLIN ENDOCRINOL METAB, vol. 90, 2005, pages 1294
YASUDA ET AL., PROC NATL ACAD SCI USA, vol. 95, 1998, pages 3597
LACEY ET AL., CELL, vol. 93, 1998, pages 165
SUDA ET AL., ENDOCR REV, vol. 20, 1999, pages 345
MARTIN ET AL., TRENDS MOL MED, vol. 11, 2005, pages 76
AOKI ET AL., J CLIN INVEST, vol. 116, 2006, pages 1525
TAKASAKI ET AL., NAT BIOTEC, vol. 15, 1997, pages 1266
CHENG ET AL., J BIOL CHEM, vol. 279, 2004, pages 8269
See also references of EP 2165716A4
HODA N.: "OPG", JOURNAL OF OSTEOPOROTIC MEDICINE, vol. 2, no. 3, 2003, pages 213 - 218
HODA N.: "OPG Seizai. Ko-RANKL Kotai", JAPANESE JOURNAL OF CLINICAL MEDICINE, vol. 63, no. 9, 2005, pages 1647 - 1653
AOKI K. ET AL.: "A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone loss", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 116, no. 6, 2006, pages 1525 - 1534, XP008126832
KOSTENUIK PJ, CURRENT OPINION IN PHARMACOLOGY, vol. 5, 2005, pages 618 - 625
MCLNTYRE JA; MARTIN L, DRUGS OF THE FUTURE, vol. 30, no. 3, 2005, pages 237 - 239
SUDA ET AL., ENDOCR REV, vol. 13, 1992, pages 66
SAMBOOK ET AL., N ENGL J MED, vol. 328, 1993, pages 1747
LUCKMAN ET AL., J BONE MINER RES, vol. 13, 1998, pages 581
WHYTE ET AL., N ENGL J MED, vol. 349, 2003, pages 457
ODVINA ET AL., J CLIN ENDOCRINOL METAB, vol. 90, 2005, pages 1294
YASUDA ET AL., PROC NATL ACAD SCI USA, vol. 95, 1998, pages 3597
LACEY ET AL., CELL, vol. 93, 1998, pages 165
SUDA ET AL., ENDOCR REV, vol. 20, 1999, pages 345
MARTIN ET AL., TRENDS MOL MED, vol. 11, 2005, pages 76
AOKI ET AL., J CLIN INVEST, vol. 116, 2006, pages 1525
TAKASAKI ET AL., NAT BIOTEC, vol. 15, 1997, pages 1266
CHENG ET AL., J BIOL CHEM, vol. 279, 2004, pages 8269
See also references of EP 2165716A4
Attorney, Agent or Firm:
HIRAKI, Yusuke et al. (3-20 Toranomon 4-chom, Minato-ku Tokyo 01, JP)
Download PDF:
Previous Patent: SILENCER
Next Patent: THERMOELECTRIC CONVERSION ELEMENT AND PROCESS FOR PRODUCING THE THERMOELECTRIC CONVERSION ELEMENT
Next Patent: THERMOELECTRIC CONVERSION ELEMENT AND PROCESS FOR PRODUCING THE THERMOELECTRIC CONVERSION ELEMENT