Title:
NOVEL BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE MUTANT AND ISOLEUCINE PRODUCTION METHOD USING SAME
Document Type and Number:
WIPO Patent Application WO/2022/124708
Kind Code:
A1
Abstract:
The present application relates to: a novel branched-chain amino acid aminotransferase mutant for reducing a by-product that is generated when producing L-isoleucine; a polynucleotide for coding the mutant; a vector comprising the polynucleotide; a microorganism comprising the mutant, the polynucleotide or the vector; and an L-isoleucine production method using the microorganism.
Inventors:
KIM HEEYEONG (KR)
SHIM JIHYUN (KR)
KIM KYUNGRIM (KR)
LEE KWANG WOO (KR)
CHOI WOOSUNG (KR)
SHIM JIHYUN (KR)
KIM KYUNGRIM (KR)
LEE KWANG WOO (KR)
CHOI WOOSUNG (KR)
Application Number:
PCT/KR2021/018224
Publication Date:
June 16, 2022
Filing Date:
December 03, 2021
Export Citation:
Assignee:
CJ CHEILJEDANG CORP (KR)
International Classes:
C12N9/10; C12N15/77; C12P13/06; C12R1/15
Foreign References:
| KR20170047725A | 2017-05-08 | |||
| JPH0847397A | 1996-02-20 | |||
| KR101751967B1 | 2017-06-30 | |||
| US10113190B2 | 2018-10-30 | |||
| US6072083A | 2000-06-06 | |||
| KR20200136813A | 2020-12-08 | |||
| US7662943B2 | 2010-02-16 | |||
| US10584338B2 | 2020-03-10 | |||
| US10273491B2 | 2019-04-30 | |||
| KR101996769B1 | 2019-10-01 | |||
| KR20200078669A | 2020-07-01 | |||
| US10662450B2 | 2020-05-26 | |||
| KR101335789B1 | 2013-12-02 |
Other References:
DATABASE PROTEIN 15 June 2019 (2019-06-15), ANONYMOUS: "MULTISPECIES: branched-chain-amino-acid transaminase [Enterobacteriaceae]", XP055941343, retrieved from GENBANK Database accession no. WP_000208520
WANG XIAOYUAN: "Strategy for improving L-isoleucine production efficiency inCorynebacterium glutamicum", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, vol. 103, no. 5, 20 January 2019 (2019-01-20), Berlin/Heidelberg, pages 2101 - 2111, XP036727143, ISSN: 0175-7598, DOI: 10.1007/s00253-019-09632-2
PEARSON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 2444
NEEDLEMANWUNSCH, J. MOL. BIOL., vol. 48, 1970, pages 443 - 453
RICE ET AL.: "Trends Genet", vol. 16, 2000, article "EMBOSS: The European Molecular Biology Open Software Suite", pages: 276 - 277
DEVEREUX, J. ET AL., NUCLEIC ACIDS RESEARCH, vol. 12, 1984, pages 387
ATSCHUL, S. F. ET AL., J MOLEC BIOL, vol. 215, 1990, pages 403
"Guide to Huge Computers", 1994, ACADEMIC PRESS
CARILLO ET AL., SIAM J APPLIED MATH, vol. 48, 1988, pages 1073
NEEDLEMAN ET AL., J MOL BIOL., vol. 48, 1970, pages 443
SMITHWATERMAN, ADV. APPL. MATH, vol. 2, 1981, pages 482
GRIBSKOV ET AL., NUCL. ACIDS RES., vol. 14, 1986, pages 6745
"Atlas Of Protein Sequence And Structure", 1979, NATIONAL BIOMEDICAL RESEARCH FOUNDATION, pages: 353 - 358
J. SAMBROOK ET AL.: "Molecular Cloning, A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
SITNICKA ET AL.: "Functional Analysis of Genes", ADVANCES IN CELL BIOLOGY, vol. 2, 2010, pages 1 - 16
SAMBROOK ET AL., MOLECULAR CLONING, 2012
NAKASHIMA N. ET AL.: "Bacterial cellular engineering by genome editing and gene silencing", INT J MOL SCI, vol. 15, no. 2, 2014, pages 2773 - 2793, XP055376889, DOI: 10.3390/ijms15022773
"Manual of Methods for General Bacteriology", 1981, AMERICAN SOCIETY FOR BACTERIOLOGY
A. J. NAIR, INTRODUCTION TO BIOTECHNOLOGY AND GENETIC ENGINEERING, 2008
See also references of EP 4245849A4
WANG XIAOYUAN: "Strategy for improving L-isoleucine production efficiency inCorynebacterium glutamicum", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, vol. 103, no. 5, 20 January 2019 (2019-01-20), Berlin/Heidelberg, pages 2101 - 2111, XP036727143, ISSN: 0175-7598, DOI: 10.1007/s00253-019-09632-2
PEARSON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 2444
NEEDLEMANWUNSCH, J. MOL. BIOL., vol. 48, 1970, pages 443 - 453
RICE ET AL.: "Trends Genet", vol. 16, 2000, article "EMBOSS: The European Molecular Biology Open Software Suite", pages: 276 - 277
DEVEREUX, J. ET AL., NUCLEIC ACIDS RESEARCH, vol. 12, 1984, pages 387
ATSCHUL, S. F. ET AL., J MOLEC BIOL, vol. 215, 1990, pages 403
"Guide to Huge Computers", 1994, ACADEMIC PRESS
CARILLO ET AL., SIAM J APPLIED MATH, vol. 48, 1988, pages 1073
NEEDLEMAN ET AL., J MOL BIOL., vol. 48, 1970, pages 443
SMITHWATERMAN, ADV. APPL. MATH, vol. 2, 1981, pages 482
GRIBSKOV ET AL., NUCL. ACIDS RES., vol. 14, 1986, pages 6745
"Atlas Of Protein Sequence And Structure", 1979, NATIONAL BIOMEDICAL RESEARCH FOUNDATION, pages: 353 - 358
J. SAMBROOK ET AL.: "Molecular Cloning, A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
SITNICKA ET AL.: "Functional Analysis of Genes", ADVANCES IN CELL BIOLOGY, vol. 2, 2010, pages 1 - 16
SAMBROOK ET AL., MOLECULAR CLONING, 2012
NAKASHIMA N. ET AL.: "Bacterial cellular engineering by genome editing and gene silencing", INT J MOL SCI, vol. 15, no. 2, 2014, pages 2773 - 2793, XP055376889, DOI: 10.3390/ijms15022773
"Manual of Methods for General Bacteriology", 1981, AMERICAN SOCIETY FOR BACTERIOLOGY
A. J. NAIR, INTRODUCTION TO BIOTECHNOLOGY AND GENETIC ENGINEERING, 2008
See also references of EP 4245849A4
Attorney, Agent or Firm:
HANOL INTELLECTUAL PROPERTY AND LAW (KR)
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