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Title:
NOVEL BROMINATED FURANONE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2017/217741
Kind Code:
A1
Abstract:
The present invention relates to a novel brominated furanone derivative, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient, wherein the novel brominated furanone derivative or a pharmaceutically acceptable salt thereof according to the present invention exhibits a quorum sensing inhibitory activity of bacteria and also can effectively inhibit the formation of biofilm of a bacteria, and thus can be used as a pharmaceutical composition containing the same as an active ingredient, thereby having an effect of being useful, for example, for periodontal diseases such as gingivitis and periodontitis, oral diseases, and the like

Inventors:
KIM BYEONG MOON (KR)
CHOI BONG KYU (KR)
SIM JAE HYUN (KR)
RYU EUN JU (KR)
PARK JI SU (KR)
BAE IL HAK (KR)
Application Number:
PCT/KR2017/006151
Publication Date:
December 21, 2017
Filing Date:
June 13, 2017
Export Citation:
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Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
International Classes:
C07D307/88; A61K8/49; A61K31/343; A61K31/345; A61Q11/00; C07D307/93
Foreign References:
JP2001335571A2001-12-04
Other References:
DATABASE Chemical Abstract Compoun 3 February 2006 (2006-02-03), retrieved from STN Database accession no. RN 873395-18-7
DATABASE Chemical Abstract Compoun 18 December 1984 (1984-12-18), retrieved from STN Database accession no. RN 93089-82-8
BENNECHE, T. ET AL.: "Synthesis of 5-(bromomethylene)furan-2(5H)-ones and 3-(bromomethylene)isobenzofuran-1(3H)-ones as Inhibitors of Microbial Quorum Sensing", NEW JOURNAL OF CHEMISTRY, vol. 32, no. 9, 2008, pages 1567 - 1572, XP055274501
LONN-STENSRUD, J. ET AL.: "Furanones, Potential Agents for Preventing Staphylococcus Epidermidis Biofilm Infections", JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, vol. 63, no. 2, 2009, pages 309 - 316, XP055449263
PARK, J. S. ET AL.: "New Bicyclic Brominated Furanones as Potent Autoinducer-2 Quorum-Sensing Inhibitors Against Bacterial Biofilm. Formation", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 137, 17 May 2017 (2017-05-17), pages 76 - 87, XP085110367
Attorney, Agent or Firm:
LEE, Won Hee (KR)
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