NOVEL C-19-HALOGEN-SUBSTITUTED, 5-SUBSTITUTED, 5-SUBSTITUTED OR 6,10 CARBOCYCLICALLY CONDENSED STEROIDS OF THE ANDROST-9(11)-ENE-SERIES, METHODS FOR THE PRODUCTION AND USE THEREOF

Title:

NOVEL C-19-HALOGEN-SUBSTITUTED, 5-SUBSTITUTED, 5-SUBSTITUTED OR 6,10 CARBOCYCLICALLY CONDENSED STEROIDS OF THE ANDROST-9(11)-ENE-SERIES, METHODS FOR THE PRODUCTION AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO2001005805

Kind Code:

A9

Abstract:

The invention relates to novel C-19-halogen-substituted steroids of the androst-9(11)-ene series, i.e. 17 beta -hydroxy-19-halogen-androsta-4,9(11)-diene-3-one of general formula (I) and to methods for the production thereof. The invention also relates to the use of novel radiohalogen-marked compounds of formula 1 as radiopharmaceuticals. The invention further relates to non-marked compounds(I) of formula I as initial products for the production of novel biologically effective 5 beta -substituted Androst-9(11)-enes of general formula (II) and novel 6 beta 19-cycloandrostadienes of formula (III), in addition to methods and uses thereof.

Inventors:

NEEF GUENTER (DE)
GOLDE ROLAND (DE)
FRITZEMEIER KARL-HEINRICH (DE)

Application Number:

PCT/DE2000/002390

Publication Date:

January 23, 2003

Filing Date:

July 17, 2000

Export Citation:

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Assignee:

SCHERING AG (DE)
NEEF GUENTER (DE)
GOLDE ROLAND (DE)
FRITZEMEIER KARL-HEINRICH (DE)

International Classes:

A61K31/566; A61K31/568; A61P13/08; A61P35/00; C07B59/00; C07J1/00; C07J53/00; A61K51/00; (IPC1-7): C07J1/00; A61K31/565; G01N33/60; C07J51/00; C07J53/00; C07J21/00; C07J71/00; C07J43/00; A61P5/36; A61P5/32

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