Title:
NOVEL CALCIUM ANTAGONISTS
Document Type and Number:
WIPO Patent Application WO/2001/078749
Kind Code:
A1
Abstract:
Novel calcium antagonists containing as the active ingredient nucleoside 5'-alkylphosphate compounds represented by the following general formula: wherein R represents a liner or branched alkyl; and B represents a base constituting a nucleoside.
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Inventors:
TANAKA TOSHIO (JP)
SUGATANI JUNKO (JP)
KISHI YUICHIRO (JP)
MATSUKAWA AKIRA (JP)
SUGATANI JUNKO (JP)
KISHI YUICHIRO (JP)
MATSUKAWA AKIRA (JP)
Application Number:
PCT/JP2000/002477
Publication Date:
October 25, 2001
Filing Date:
April 17, 2000
Export Citation:
Assignee:
FUSO PHARMACEUTICAL IND (JP)
TANAKA TOSHIO (JP)
SUGATANI JUNKO (JP)
KISHI YUICHIRO (JP)
MATSUKAWA AKIRA (JP)
TANAKA TOSHIO (JP)
SUGATANI JUNKO (JP)
KISHI YUICHIRO (JP)
MATSUKAWA AKIRA (JP)
International Classes:
A61K31/7072; A61K31/7076; A61P7/02; A61P9/06; A61P9/10; A61P43/00; C07H19/10; C07H19/20; (IPC1-7): A61K31/7072; A61K31/7076; A61P7/02; A61P9/06; A61P9/10; A61P43/00
Domestic Patent References:
| WO1998045309A1 | 1998-10-15 |
Foreign References:
| JPH10226696A | 1998-08-25 |
Other References:
KIYOTAKA MACHIDA ET AL.: "Inhibitory effects of nucleoside 5'-alkylphosphates on sexual aggregation in saccharomyces cerevisiae", FEMS MICROBIOLY LETTERS,, vol. 147, no. 1, 1997, pages 17 - 22, XP002927093
TAKAYUKI SHIRAISHI, KAZUO TEZUKA, YUTAKA UDA.: "Selective inhibition of lignoceroyl-CoA synthetase by adenosine 5'-alkylphosphates", FEBS LETTERS,, vol. 352, no. 3, 1994, pages 353 - 355, XP002927094
SIXTUS HYNIE, JIRI SMRT.: "The inhibitory effects of some adenosine nucleolipids on the lipolysis in rat epididymal fat pads in vitro", COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS,, vol. 44, no. 5, 1979, pages 1651 - 1656, XP002927095
SIXTUS HYNIE, JIRI SMRT.: "Effects of adenosine 5'-phosphate esters with lipid hydroxy compounds(adenosine nucleolipids) on the activity of enzymes of cyclic amp system", FEBS LETTERS,, vol. 94, no. 2, 1978, pages 339 - 341, XP002927096
TAKAYUKI SHIRAISHI, KAZUO TEZUKA, YUTAKA UDA.: "Selective inhibition of lignoceroyl-CoA synthetase by adenosine 5'-alkylphosphates", FEBS LETTERS,, vol. 352, no. 3, 1994, pages 353 - 355, XP002927094
SIXTUS HYNIE, JIRI SMRT.: "The inhibitory effects of some adenosine nucleolipids on the lipolysis in rat epididymal fat pads in vitro", COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS,, vol. 44, no. 5, 1979, pages 1651 - 1656, XP002927095
SIXTUS HYNIE, JIRI SMRT.: "Effects of adenosine 5'-phosphate esters with lipid hydroxy compounds(adenosine nucleolipids) on the activity of enzymes of cyclic amp system", FEBS LETTERS,, vol. 94, no. 2, 1978, pages 339 - 341, XP002927096
Attorney, Agent or Firm:
Aoyama, Tamotsu (Shiromi 1-chome Chuo-ku, Osaka-shi Osaka, JP)
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