Title:
NOVEL CANNABIMIMETIC LIGANDS
Document Type and Number:
WIPO Patent Application WO2002058636
Kind Code:
A3
Abstract:
Disclosed are heterocyclic compounds and methods for their manufacture. The disclosed compounds are surprisingly potent and selective cannabinoids. Also disclosed are methods of using the disclosed compounds, including use of the disclosed compounds to stimulate a cannabinoid receptor, to provide a physiological effect in an animal or individual and to treat a condition in an animal or individual.
Inventors:
MAKRIYANNIS ALEXANDROS (US)
DENG HONGFENG (US)
DENG HONGFENG (US)
Application Number:
PCT/US2002/002157
Publication Date:
October 10, 2002
Filing Date:
January 25, 2002
Export Citation:
Assignee:
UNIV CONNECTICUT (US)
MAKRIYANNIS ALEXANDROS (US)
DENG HONGFENG (US)
MAKRIYANNIS ALEXANDROS (US)
DENG HONGFENG (US)
International Classes:
A61K31/235; A61K31/395; A61K31/4545; A61P1/08; A61P15/08; A61P15/10; A61P25/00; A61P25/04; A61P25/08; A61P25/14; A61P25/28; A61P27/06; A61P29/00; A61P35/00; A61P37/02; A61P43/00; C07C69/76; C07D257/08; (IPC1-7): A61K31/395; A61K31/444; A61K31/235; A61P29/00; C07C69/76; C07D257/08
Other References:
CROCE ET AL.: "Reaction of thiete 1,1-dioxide with alpha-chlorobenzalphenylhydrazine and methyl phenylhydrazonochloroacetate", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 15, no. 3, May 1978 (1978-05-01), pages 515 - 517, XP002952581
CROCE ET AL.: "Reactions of hydrazonoyl halides with imidazoles and benzimidazoles", J. CHEM. SOC., PERKIN TRANS. 1, vol. 2, 1979, pages 330 - 332, XP002952582
TEWARI ET AL.: "1,3-Dipolar cycloaddition and nucleophylic substitution reactions of C-acetyl and C-ethoxycarbonyl derivative of hydrazidoyl bromides", TETRAHEDRON, vol. 39, no. 1, 1983, pages 129 - 136, XP002952583
MOLTENI ET AL.: "Nitrilimine cycloadditions in aqueous media", J. CHEM. SOC., PERKIN TRANS. 1, vol. 22, October 2000 (2000-10-01), pages 3742 - 3745, XP002952584
SHIUE ET AL.: "Phenyl-carbonyl coupling reactions promoted by samarium diiodide and hexamethylphosphoramide", J. ORG. CHEM., vol. 62, no. 14, 11 July 1997 (1997-07-11), pages 4643 - 4649, XP000698594
CROCE ET AL.: "Reactions of hydrazonoyl halides with imidazoles and benzimidazoles", J. CHEM. SOC., PERKIN TRANS. 1, vol. 2, 1979, pages 330 - 332, XP002952582
TEWARI ET AL.: "1,3-Dipolar cycloaddition and nucleophylic substitution reactions of C-acetyl and C-ethoxycarbonyl derivative of hydrazidoyl bromides", TETRAHEDRON, vol. 39, no. 1, 1983, pages 129 - 136, XP002952583
MOLTENI ET AL.: "Nitrilimine cycloadditions in aqueous media", J. CHEM. SOC., PERKIN TRANS. 1, vol. 22, October 2000 (2000-10-01), pages 3742 - 3745, XP002952584
SHIUE ET AL.: "Phenyl-carbonyl coupling reactions promoted by samarium diiodide and hexamethylphosphoramide", J. ORG. CHEM., vol. 62, no. 14, 11 July 1997 (1997-07-11), pages 4643 - 4649, XP000698594
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