NOVEL CARBAPENEM DERIVATIVE

Title:

NOVEL CARBAPENEM DERIVATIVE

Document Type and Number:

WIPO Patent Application WO/1996/001261

Kind Code:

A1

Abstract:

A carbapenem compound represented by general formula (I) or a salt thereof, wherein ring A represents a three- to seven-membered ring having at least one nitrogen atom and may have a substituent(s) in addition to R6; R1 represents hydrogen or methyl, R2 and R5 represent each independently hydrogen or a hydroxyl-protecting group; R3 represents a carboxyl-protecting group; R4 represents hydrogen, lower alkyl or an amino-protecting group; R6 represents (1) hydrogen, (2) lower alkyl which may be substituted by optionally protected hydroxy, carbamoyl, formimidoyl, acetimidoyl or -NR7R8 (wherein R7 and R8 represent each independently hydrogen, lower alkyl or an amino-protecting group), or (3) an amino- or imino-protecting group; and m represents 0 or 1. The compound has a potent antibacterial activity against both Gram-positive and Gram-negative bacteria, an excellent resistance to 'beta'-lactamase and DHP-I, and an excellent safety for the human body, thus being useful as a medicine.

Inventors:

SATO NOBUAKI (JP)
SASHO MANABU (JP)
KAMATA ATSUSHI (JP)
SUZUKI TAKAAKI (JP)
SUGIYAMA ISAO (JP)
KATSU KANEMASA (JP)
SUZUKI TAKESHI (JP)

Application Number:

PCT/JP1995/001299

Publication Date:

January 18, 1996

Filing Date:

June 29, 1995

Export Citation:

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Assignee:

EISAI CO LTD (JP)
SATO NOBUAKI (JP)
SASHO MANABU (JP)
KAMATA ATSUSHI (JP)
SUZUKI TAKAAKI (JP)
SUGIYAMA ISAO (JP)
KATSU KANEMASA (JP)
SUZUKI TAKESHI (JP)

International Classes:

A61K31/397; A61K31/40; A61K31/445; C07D477/00; A61P31/04; C07D477/20; (IPC1-7): C07D477/20; A61K31/40; A61K31/445

Foreign References:

JPS63179876A	1988-07-23
JPH021491A	1990-01-05
JPH0215080A	1990-01-18
JPH04321688A	1992-11-11

Other References: