Title:
NOVEL CARBAPENEM DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/1996/007655
Kind Code:
A1
Abstract:
A novel compound represented by general formula [I], a process for producing the same, and the use thereof as an antibacterial (wherein R1 represents hydrogen or lower alkyl; R2 represents hydrogen, ester residue or alkali metal; and R3 represents a group represented by any of general formulae (a), (b) or (c), wherein R4 represents hydrogen, formyl, or optionally substituted lower alkyl, lower alkanoyl or lower alkylsulfonyl; and R5, R6 and R7 represent each independently oxo or thioxo). This compound has a potent antibacterial activity against gram-positive and gram-negative bacteria including MRSA, an excellent resistance against 'beta'-lactamases and DHD-1 and a safety for the central nervous system, thus being useful as an antibacterial. The ester derivatives thereof are perorally absorbable and expected to greatly contribute to the treatment of infectious diseases.
Inventors:
NAKAGAWA SUSUMU
FUKATSU HIROSHI
KATO YOSHIAKI
SATO YUICHI
KANESAKA TOMOYASU
FUKATSU HIROSHI
KATO YOSHIAKI
SATO YUICHI
KANESAKA TOMOYASU
Application Number:
PCT/JP1995/001756
Publication Date:
March 14, 1996
Filing Date:
September 04, 1995
Export Citation:
Assignee:
BANYU PHARMA CO LTD (JP)
International Classes:
C07D477/20; (IPC1-7): C07D477/20; A61K31/40; A61K31/44
Foreign References:
| JPH0249783A | 1990-02-20 | |||
| JPH04279588A | 1992-10-05 | |||
| JPS60132985A | 1985-07-16 |
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