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Title:
NOVEL CAROTENOID-RELATED DERIVATIVES, AND SALTS, ESTERS, OR AMIDES THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/027304
Kind Code:
A1
Abstract:
Provided are carotenoid derivatives having exceptional hydrophilicity and oral absorptivity. A carotenoid-related compound represented by the formula (in the formula, X represents a carbonyl group or a methylene group, and Z1 and Z2 are the same or different and represent a group selected from (a), (b), (c), and (d) below: (a) a hydroxy group (however, Z1 and Z2 are not simultaneously hydroxy groups); (b) -OR1 (R1 represents an optionally substituted hydrocarbon group or the like); (c) -SR2 (R2 represents an optionally substituted hydrocarbon group or the like); (d) -NR3R4 (R3 represents a hydrogen atom, an optionally substituted hydrocarbon group, or the like, R4 represents a hydrogen atom, an optionally substituted hydrocarbon group, or the like, and R3 and R4 may form a heterocycle together with nitrogen atoms)), pharmacologically acceptable salts thereof, or pharmacologically acceptable esters or amides thereof.

Inventors:
YOKOYAMA TOMIHISA (JP)
NISHIDA YASUHIRO (JP)
OGAWA MAKOTO (JP)
YAMANO KATSUHIRO (JP)
FUJITA TAKASHI (JP)
MORIIZUMI KIYOTAKA (JP)
SHINOHARA RYOMA (JP)
KOBAYASHI SATOSHI (JP)
SAKATA RYO (JP)
FUKUYAMA KEI (JP)
NAKAZAWA KENTA (JP)
IWANO YUJI (JP)
Application Number:
JP2019/030382
Publication Date:
February 06, 2020
Filing Date:
August 01, 2019
Export Citation:
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Assignee:
ASTA PHARMACEUTICALS CO LTD (JP)
International Classes:
C07C403/24; A61K31/015; A61K31/122; A61K31/13; A61K31/133; A61K31/136; A61K31/19; A61K31/194; A61K31/215; A61K31/275; A61K31/395; A61K31/40; A61K31/403; A61K31/4178; A61K31/427; A61K31/438; A61K31/444; A61K31/4545; A61K31/496; A61K31/5355; A61K31/541; A61K31/55; A61K31/551; A61K31/655; A61P37/02; A61P39/06; A61P43/00; C07D207/16; C07D209/44; C07D211/14; C07D211/44; C07D211/58; C07D211/62; C07D213/36; C07D213/73; C07D223/04; C07D233/61; C07D243/08; C07D257/04; C07D277/04; C07D295/116; C07D295/15; C07D519/00
Domestic Patent References:
WO2005102356A12005-11-03
WO2006105214A22006-10-05
WO2015178404A12015-11-26
Foreign References:
JP2006517197A2006-07-20
Other References:
INANAGA, JUNJI ET AL.: "Transformation of zeaxanthin into 3,3'-diamino- and dimercapto-beta -carotene derivatives", MEMOIRS OF THE FACULTY OF SCIENCE, vol. 17, no. 1, 1989, pages 109 - 112
BAI, AIPING ET AL.: "All-trans retioic acid down- regulates inflammatory responses by shifting the Treg/Th17 profile in human ulcerative and murine colitis", J. LEUK. BIOL., vol. 86, 2009, pages 959 - 969, XP055683612
KAWASHIMA, TADAOMI: "A marine carotenoid, Fucoxanthin, induces regulatory T cells and inhibits Th17 cell differentiation in vitro", BIOSCI. BIOTECHNOL. BIOCHEM., vol. 75, no. 10, 2011, pages 2066 - 2069
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
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