Title:
NOVEL CATHEPSIN L-LIKE CYSTEINE PROTEASE ORIGINATING IN PINK SHRIMP
Document Type and Number:
WIPO Patent Application WO/2003/106677
Kind Code:
A1
Abstract:
It is intended to search for and produce cathepsin L which retains a high activity under neutral to alkaline conditions in a low temperature region. A novel cathepsin L sustaining its activity in a low temperature region can be successfully found out in the hepatopancreas of pink shrimp (Pandalus eous) growing in Japan. Further, the gene sequence of this novel cathepsin L is determined, which makes it possible to produce it by a gene recombination method.
Inventors:
AOKI HITOSHI (JP)
WATABE SHUGO (JP)
AHSAN MD NAZMUL (JP)
WATABE SHUGO (JP)
AHSAN MD NAZMUL (JP)
Application Number:
PCT/JP2003/007661
Publication Date:
December 24, 2003
Filing Date:
June 17, 2003
Export Citation:
Assignee:
NICHIREI KK (JP)
AOKI HITOSHI (JP)
WATABE SHUGO (JP)
AHSAN MD NAZMUL (JP)
AOKI HITOSHI (JP)
WATABE SHUGO (JP)
AHSAN MD NAZMUL (JP)
International Classes:
C12N1/15; C12N1/19; C12N1/21; C12N9/64; C12N15/57; (IPC1-7): C12N15/09; C12N9/64; C12N15/57; C12N1/15; C12N1/19; C12N1/21; C12N5/10
Other References:
LAYCOCK MAURICE V. ET AL.: "Molecular cloning of three cDNAs that encode cysteine proteinases in the digestive gland of the American lobster (Homarus americanus)", FEBS LETT., vol. 292, no. 1-2, 1991, pages 155 - 120, XP001105191
LE BOULAY C. ET AL.: "Molecular cloning and sequencing of two cDNAs encoding cathepsin L-related cysteine proteinases in the nervous system and in the stomach of the Norway lobster (nephrops norvegicus)", COMP. BIOCHEM. PHYSIOL., vol. 111B, no. 3, 1995, pages 353 - 359, XP002971089
LE BOULAY C. ET AL.: "Cloning and expression of cathepsin L-like proteinases in the hepatopancreas of the shrimp penaeus vannamel during the intermolt cycle", J. COM. PHYSIOL. B, vol. 166, 1996, pages 310 - 318, XP002971090
JOSEPH LOREN J. ET AL.: "Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L", J. CLIN. INVEST., vol. 81, no. 5, 1988, pages 1621 - 1629, XP002971091
BERRI MUSTAPHA ET AL.: "Purification and characterization of a new potential in vivo inhibitor of cathepsin L from bovine skeletal muscle", COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY, vol. 119B, no. 2, 1998, pages 283 - 288, XP002971092
LE BOULAY C. ET AL.: "Molecular cloning and sequencing of two cDNAs encoding cathepsin L-related cysteine proteinases in the nervous system and in the stomach of the Norway lobster (nephrops norvegicus)", COMP. BIOCHEM. PHYSIOL., vol. 111B, no. 3, 1995, pages 353 - 359, XP002971089
LE BOULAY C. ET AL.: "Cloning and expression of cathepsin L-like proteinases in the hepatopancreas of the shrimp penaeus vannamel during the intermolt cycle", J. COM. PHYSIOL. B, vol. 166, 1996, pages 310 - 318, XP002971090
JOSEPH LOREN J. ET AL.: "Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L", J. CLIN. INVEST., vol. 81, no. 5, 1988, pages 1621 - 1629, XP002971091
BERRI MUSTAPHA ET AL.: "Purification and characterization of a new potential in vivo inhibitor of cathepsin L from bovine skeletal muscle", COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY, vol. 119B, no. 2, 1998, pages 283 - 288, XP002971092
Attorney, Agent or Firm:
Hiraki, Yusuke (3-20 Toranomon 4-chom, Minato-ku Tokyo, JP)
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