Title:
NOVEL CATIONIC LIPIDS AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2011/141705
Kind Code:
A8
Abstract:
The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.
Inventors:
HEYES JAMES (CA)
WOOD MARK (CA)
MARTIN ALAN (CA)
WOOD MARK (CA)
MARTIN ALAN (CA)
Application Number:
PCT/GB2011/000723
Publication Date:
January 03, 2013
Filing Date:
May 12, 2011
Export Citation:
Assignee:
PROTIVA BIOTHERAPEUTICS INC (CA)
HEYES JAMES (CA)
WOOD MARK (CA)
MARTIN ALAN (CA)
HEYES JAMES (CA)
WOOD MARK (CA)
MARTIN ALAN (CA)
International Classes:
C07C217/08; A61K47/48; A61K48/00; A61K49/04; C07C217/46; C07C229/12; C07C229/30; C07C237/06; C07C271/20; C07C327/06; C07D233/60; C07D249/04; C12N15/11; C12N15/88
Attorney, Agent or Firm:
CAMPBELL, Patrick, John, Henry (14 South SquareGray's Inn, London WC1R 5JJ, GB)
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