Title:
NOVEL CATIONIC LIPIDS WITH SHORT LIPID CHAINS FOR OLIGONUCLEOTIDE DELIVERY
Document Type and Number:
WIPO Patent Application WO/2011/043913
Kind Code:
A3
Abstract:
The instant invention provides for novel cationic lipids with short lipid chains that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides, to facilitate the cellular uptake and endosomal escape, and to knockdown target mRNA both in vitro and in vivo while decreasing inflammatory toxicities.
Inventors:
CAMERON MARK (US)
DAVIS JENNIFER R (US)
WANG WEIMIN (US)
DAVIS JENNIFER R (US)
WANG WEIMIN (US)
Application Number:
PCT/US2010/049420
Publication Date:
June 14, 2012
Filing Date:
September 20, 2010
Export Citation:
Assignee:
MERCK SHARP & DOHME (US)
CAMERON MARK (US)
DAVIS JENNIFER R (US)
WANG WEIMIN (US)
CAMERON MARK (US)
DAVIS JENNIFER R (US)
WANG WEIMIN (US)
International Classes:
A61K9/127; C07C229/00
Foreign References:
| US20080188675A1 | 2008-08-07 | |||
| US20060257464A9 | 2006-11-16 |
Other References:
See also references of EP 2485770A4
Attorney, Agent or Firm:
MERCK SHARP & DOHME CORP. (Rahway, New Jersey, US)
Download PDF: