NOVEL CATIONIC POLYPHOSPHAZENE COMPOUND, POLYPHOSPHAZENES-DRUG CONJUGATE COMPOUND AND METHOD FOR PREPARING SAME

Title:

NOVEL CATIONIC POLYPHOSPHAZENE COMPOUND, POLYPHOSPHAZENES-DRUG CONJUGATE COMPOUND AND METHOD FOR PREPARING SAME

Document Type and Number:

WIPO Patent Application WO/2015/137777

Kind Code:

A1

Abstract:

The present invention relates to: a cationic linear polyphosphazene compound incorporating hydrophilic polyethylene glycol and lysine as a spacer group, oligopeptide comprising lysine, and one selected from the group consisting of aminoethanol, aminopropanol, aminobutanol, aminopentanol and aminohexanol; a polyphosphazenes-drug conjugate compound which is obtained by chemically bonding a hydrophobic drug to said compound; and a method for preparing the same, wherein the compound of the present invention is excellent in selectivity to cancer tissues and has very low toxicity, and thus is a new material with high possibility of commercialization as an anti-cancer drug.

Inventors:

SOHN YOUN SOO (KR)
JUN YONG JOO (KR)
AVAJI PRAKASH GOUDA (KR)

Application Number:

PCT/KR2015/002488

Publication Date:

September 17, 2015

Filing Date:

March 13, 2015

Export Citation:

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Assignee:

CNPHARM CO LTD (KR)
SOHN YOUN SOO (KR)

International Classes:

C08G79/02; A61K31/74

Foreign References:

KR100773029B1	2007-11-05
US20130324490A1	2013-12-05
KR20080110473A	2008-12-18
KR20040092812A	2004-11-04
KR101083419B1	2011-11-14

Other References: