Title:
NOVEL CELL GROWTH PROMOTER
Document Type and Number:
WIPO Patent Application WO/2005/035562
Kind Code:
A1
Abstract:
It is intended to provide an agent promoting the growth of cells, in particular, embryonic stem cells and somatic stem cells. By using a fused protein or a chemical conjugation characterized by containing a protein-transfer domain and ERas protein, the proliferation of cells, in particular, embryonic stem cells and somatic stem cells can be promoted. This cell growth promoter can be reversibly prepared and, therefore, is clinically applicable at a high level compared with the gene transfer method.
Inventors:
YAMANAKA SHINYA (JP)
Application Number:
PCT/JP2004/015009
Publication Date:
April 21, 2005
Filing Date:
October 05, 2004
Export Citation:
Assignee:
YAMANAKA SHINYA (JP)
SUMITOMO PHARMA (JP)
SUMITOMO PHARMA (JP)
International Classes:
C07K14/47; C07K14/475; C12N1/15; C12N1/19; C12N1/21; C12N5/0735; C12N15/12; (IPC1-7): C07K14/47; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/00; C12N15/12; C12P21/02
Foreign References:
| JP2702285B2 | 1998-01-21 |
Other References:
TAKAHASHI K. ET AL: "Role of ERas in promoting tumour-like properties in mouse embryonic stem cells", NATURE, vol. 423, 29 May 2003 (2003-05-29), pages 541 - 545, XP002982414
FUTAKI S. ET AL: "Arginine-rich Peptides", J. BIOL. CHEM., vol. 276, no. 8, 2001, pages 5836 - 5840, XP002210171
LIN YZ. ET AL: "Inhibition of Nuclear Translocation of Transcription Factor NF-kB by a Synthetic Peptide Containing a Cell Membrane-permeable Motif and Nuclear Localization Sequence", J. BIOL. CHEM., vol. 270, no. 24, 1995, pages 14255 - 14258, XP002050723
BAUSS F. ET AL.: "Effect of 17beta-Estradiol-Bisphosphonate Conjugates, Potential Bone-Seeking Estrogen Pro-Drugs, on 17beta-Estradiol Serum Kinetics and Bone Mass in Rats", CALCIFIRD TISSUE. INT., vol. 59, 1996, pages 168 - 173, XP008037971
CHAMBERS I. ET AL.: "Functional Expression Cloning of Nanog, a Pluripotency Sustaining Factor in Embryonic Stem Cells", CELL, vol. 113, 30 May 2003 (2003-05-30), pages 643 - 655, XP002290473
FUTAKI S. ET AL: "Arginine-rich Peptides", J. BIOL. CHEM., vol. 276, no. 8, 2001, pages 5836 - 5840, XP002210171
LIN YZ. ET AL: "Inhibition of Nuclear Translocation of Transcription Factor NF-kB by a Synthetic Peptide Containing a Cell Membrane-permeable Motif and Nuclear Localization Sequence", J. BIOL. CHEM., vol. 270, no. 24, 1995, pages 14255 - 14258, XP002050723
BAUSS F. ET AL.: "Effect of 17beta-Estradiol-Bisphosphonate Conjugates, Potential Bone-Seeking Estrogen Pro-Drugs, on 17beta-Estradiol Serum Kinetics and Bone Mass in Rats", CALCIFIRD TISSUE. INT., vol. 59, 1996, pages 168 - 173, XP008037971
CHAMBERS I. ET AL.: "Functional Expression Cloning of Nanog, a Pluripotency Sustaining Factor in Embryonic Stem Cells", CELL, vol. 113, 30 May 2003 (2003-05-30), pages 643 - 655, XP002290473
Attorney, Agent or Firm:
Isobe, Yutaka (Dainippon Sumitomo Pharma Co. Ltd., 1-98,
Kasugadenaka 3-chome, Konohana-k, Osaka-shi Osaka, JP)
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