Title:
NOVEL CELL MEMBRANE-PERMEATING PEPTIDE
Document Type and Number:
WIPO Patent Application WO/2016/186140
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a novel membrane permeability-improving agent which can be applied to polymeric drugs. More specifically, the present invention addresses the problem of providing: a drug carrier which can improve the absorption efficiency of a polymeric drug in the small intestine; and a membrane permeation-improving agent containing the carrier. According to the present invention, a cell membrane-permeating peptide can be provided, which comprises an amino acid sequence selected from the group consisting of the following amino acid sequences: an amino acid sequence DNPGN (SEQ ID NO: 1); an amino acid sequence SRPAF (SEQ ID NO: 2); an amino acid sequence NDPRN (SEQ ID NO: 3); and an amino acid sequence MSVAN (SEQ ID NO: 4). According to the present invention, a cell membrane-permeating composition can also be provided, which comprises the peptide and a physiologically active substance.
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Inventors:
ITO SHINGO (JP)
OHTSUKI SUMIO (JP)
OHTSUKI SUMIO (JP)
Application Number:
PCT/JP2016/064767
Publication Date:
November 24, 2016
Filing Date:
May 18, 2016
Export Citation:
Assignee:
NAT UNIV CORP KUMAMOTO UNIV (JP)
International Classes:
C07K7/64; A61K9/127; A61K31/711; A61K31/713; A61K38/28; A61K45/00; A61K47/40; A61K48/00; A61P1/08; A61P1/18; A61P3/10; A61P7/02; A61P7/10; A61P9/00; A61P9/12; A61P11/06; A61P25/16; A61P25/18; A61P25/28; A61P35/00; A61P37/08; C07K14/62; C07K19/00; C12N15/113
Foreign References:
| JP2010100781A | 2010-05-06 | |||
| JP2006304619A | 2006-11-09 |
Other References:
AKIRA YAMAMOTO: "Improvement of Transmucosal Delivery of Peptide and Protein Drugs", JOURNAL OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY, vol. 74, no. 1, 2014, Japan, pages 19 - 26, XP055331151
OHURA K ET AL.: "Evaluation of Transport Mechanism of Prodrugs and Parent Drugs Formed by Intracellular Metabolism in Caco-2 Cells with Modified Carboxylesterase Activity: Temocapril as a Model Case", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 100, no. 9, 2011, pages 3985 - 3994, XP055331153
OHURA K ET AL.: "Evaluation of Transport Mechanism of Prodrugs and Parent Drugs Formed by Intracellular Metabolism in Caco-2 Cells with Modified Carboxylesterase Activity: Temocapril as a Model Case", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 100, no. 9, 2011, pages 3985 - 3994, XP055331153
Attorney, Agent or Firm:
OSAWA KENICHI (JP)
大澤 健一 (JP)
大澤 健一 (JP)
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