Title:
NOVEL CEPHALOTAXANE DERIVATIVES AND PROCESS FOR THEIR PREPARATION
Document Type and Number:
WIPO Patent Application WO1999048894
Kind Code:
B1
Abstract:
The present invention concerns a new general process for asymmetric hemisynthesis of harringtonines and their analogs, that are alcaloïds used in chimiotherapy. This process comprises direct esterification of a natural cephalotaxine with an acylating compound constituted of a side chain precursor which backbone and fonctionalization are entirely preformed.
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Inventors:
ROBIN JEAN-PIERRE (FR)
ROBIN JULIE (FR)
CAVOLEAU SYLVIE (FR)
CHAUVIAT LUDOVIC (FR)
CHARBONNEL SANDRA (FR)
DHAL ROBERT (FR)
DUJARDIN GILLES (FR)
FOURNIER FLORENCE (FR)
GILET CHRYSTELLE (FR)
GIRODIER LAURENT (FR)
MEVELEC LAURENCE (FR)
POUTOT SANDRINE (FR)
ROUAUD SYLVIE (FR)
ROBIN JULIE (FR)
CAVOLEAU SYLVIE (FR)
CHAUVIAT LUDOVIC (FR)
CHARBONNEL SANDRA (FR)
DHAL ROBERT (FR)
DUJARDIN GILLES (FR)
FOURNIER FLORENCE (FR)
GILET CHRYSTELLE (FR)
GIRODIER LAURENT (FR)
MEVELEC LAURENCE (FR)
POUTOT SANDRINE (FR)
ROUAUD SYLVIE (FR)
Application Number:
PCT/IB1999/000491
Publication Date:
November 04, 1999
Filing Date:
March 17, 1999
Export Citation:
Assignee:
ONCOPHARM CORP (US)
ROBIN JEAN PIERRE (FR)
ROBIN JULIE (FR)
CAVOLEAU SYLVIE (FR)
CHAUVIAT LUDOVIC (FR)
CHARBONNEL SANDRA (FR)
DHAL ROBERT (FR)
DUJARDIN GILLES (FR)
FOURNIER FLORENCE (FR)
GILET CHRYSTELLE (FR)
GIRODIER LAURENT (FR)
MEVELEC LAURENCE (FR)
POUTOT SANDRINE (FR)
ROUAUD SYLVIE (FR)
ROBIN JEAN PIERRE (FR)
ROBIN JULIE (FR)
CAVOLEAU SYLVIE (FR)
CHAUVIAT LUDOVIC (FR)
CHARBONNEL SANDRA (FR)
DHAL ROBERT (FR)
DUJARDIN GILLES (FR)
FOURNIER FLORENCE (FR)
GILET CHRYSTELLE (FR)
GIRODIER LAURENT (FR)
MEVELEC LAURENCE (FR)
POUTOT SANDRINE (FR)
ROUAUD SYLVIE (FR)
International Classes:
A61K31/55; A61P35/00; C07C57/13; C07C59/42; C07C59/48; C07C69/732; C07D303/48; C07D305/08; C07D309/08; C07D453/04; C07D487/04; C07D491/147; C07D491/20; C07D493/10; (IPC1-7): C07D491/20; A61K31/55; C07D453/04; C07D309/08; C07D303/48; C07D305/08; C07C57/13; C07D493/10
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