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Patent Searching and Data


Title:
NOVEL CEPHEM DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2011/136268
Kind Code:
A1
Abstract:
Provided is a cephem compound represented by the following formula, having a broad antibacterial spectrum, and exhibiting strong antibacterial activity particularly with respect to β-lactamase producing gram-negative bacteria. Also provided is a pharmaceutical composition containing the same. Formula (I) : [In the formula, W and U are as described in the description, R1 is as described in the description, and R2 A and R2B are as described in the description. However, if R1 is an aminothiadiazole or aminothiazole in which the amino group may be protected, R2A and R2B, rather than being oxime groups which may combine to have substituents, are 6-membered aromatic heterocyclic groups having 1 to 3 nitrogen atoms, and ring A is a benzene ring, R3 is a hydrogen atom, -OCH3 or -NH-CH(=O), k is an integer from 0 to 2, and R4 is as described in the description. D and E are a) or b) as denoted in the description.]

Inventors:
KUSANO HIROKI (JP)
YAMAWAKI KENJI (JP)
Application Number:
PCT/JP2011/060259
Publication Date:
November 03, 2011
Filing Date:
April 27, 2011
Export Citation:
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Assignee:
SHIONOGI & CO (JP)
KUSANO HIROKI (JP)
YAMAWAKI KENJI (JP)
International Classes:
C07D501/42; A61K31/5365; A61K31/546; A61P31/04; C07D501/44; C07D501/46; C07D519/00; C07D519/06
Domestic Patent References:
WO2003078440A12003-09-25
WO2010050468A12010-05-06
Foreign References:
JPH03173893A1991-07-29
JPS62158291A1987-07-14
JPH06510523A1994-11-24
JPH02117678A1990-05-02
JPH0215090A1990-01-18
Attorney, Agent or Firm:
TAKAYAMA, Hirotsugu et al. (JP)
Hiromitsu Takayama (JP)
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Claims: