Title:
NOVEL CHIMERIC RECEPTOR COMPOSITION, RECOMBINANT VECTOR, CELL, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/284700
Kind Code:
A1
Abstract:
A novel chimeric receptor composition, a recombinant vector, a cell, and an application thereof. The novel chimeric receptor composition comprises a conventional chimeric antigen receptor (CAR), and an NKG2D chimeric receptor comprising full-length sequences or truncated fragments of NKG2D, DAP10, and/or DAP12, referred to as a SNR-armed CAR. The chimeric receptor composition enables a conventional CAR-T cell to express an NKG2D extracellular region and an intracellular signal region, expands a CAR-T antigen recognition spectrum, solves the tumor heterogeneity, achieves a lower level of factor release while enhancing the killing capability of CAR-T on tumor cells expressing target antigens, reduces the possibility of factor storm occurrence, and improves the CAR-T security.
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Inventors:
SUN MINMIN (CN)
LI YANTAO (CN)
WANG YOUTAO (CN)
HAO RUIDONG (CN)
ZHONG YUNPENG (CN)
YI QIAOYONG (CN)
LI YANTAO (CN)
WANG YOUTAO (CN)
HAO RUIDONG (CN)
ZHONG YUNPENG (CN)
YI QIAOYONG (CN)
Application Number:
PCT/CN2022/105029
Publication Date:
January 19, 2023
Filing Date:
July 12, 2022
Export Citation:
Assignee:
SUZHOU IMMUNOFOCO BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07K19/00; A61K39/00; A61P35/00; C12N5/10
Foreign References:
| CN113621073A | 2021-11-09 | |||
| CN111995688A | 2020-11-27 | |||
| CN110636851A | 2019-12-31 | |||
| CN109280087A | 2019-01-29 | |||
| US20210024608A1 | 2021-01-28 | |||
| CN110698564A | 2020-01-17 | |||
| CN107759701A | 2018-03-06 | |||
| CN110981970A | 2020-04-10 | |||
| CN113621073A | 2021-11-09 |
Other References:
NG YU-YANG, TAY JOHAN C.K., LI ZHENDONG, WANG JUNJIAN, ZHU JIANGQING, WANG SHU: "T Cells Expressing NKG2D CAR with a DAP12 Signaling Domain Stimulate Lower Cytokine Production While Effective in Tumor Eradication", MOLECULAR THERAPY, vol. 29, no. 1, 1 January 2021 (2021-01-01), US , pages 75 - 85, XP055963193, ISSN: 1525-0016, DOI: 10.1016/j.ymthe.2020.08.016
ZHAO RUOCONG, CHENG LIN, JIANG ZHIWU, WEI XINRU, LI BAIHENG, WU QITING, WANG SUNA, LIN SIMIAO, LONG YOUGUO, ZHANG XUCHAO, WU YILON: "DNAX-activating protein 10 co-stimulation enhances the anti-tumor efficacy of chimeric antigen receptor T cells", ONCOIMMUNOLOGY, vol. 8, no. 1, 2 January 2019 (2019-01-02), pages 1 - 12, XP093024066, DOI: 10.1080/2162402X.2018.1509173
"Remington's Pharmaceutical Sciences", 1990, MACK PUBLISHING CO.
"Remington, The Science and Practice of Pharmacy", 2005, MACK PUBLISHING
ZHAO RUOCONG, CHENG LIN, JIANG ZHIWU, WEI XINRU, LI BAIHENG, WU QITING, WANG SUNA, LIN SIMIAO, LONG YOUGUO, ZHANG XUCHAO, WU YILON: "DNAX-activating protein 10 co-stimulation enhances the anti-tumor efficacy of chimeric antigen receptor T cells", ONCOIMMUNOLOGY, vol. 8, no. 1, 2 January 2019 (2019-01-02), pages 1 - 12, XP093024066, DOI: 10.1080/2162402X.2018.1509173
"Remington's Pharmaceutical Sciences", 1990, MACK PUBLISHING CO.
"Remington, The Science and Practice of Pharmacy", 2005, MACK PUBLISHING
Attorney, Agent or Firm:
ZHONG LUN LAW FIRM (CN)
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