Title:
NOVEL CITRIC ACID DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2017/077707
Kind Code:
A1
Abstract:
Compounds (citric acid derivatives) represented by formulae (1) and (2) are novel compounds that have hepatic disorder inhibitory effect, and are able to be used as hepatic disorder inhibitors and food additives.
(In the formulae, R1 represents a C1-C3 alkyl group which may have a carboxyl group or a hydroxyl group and R2 represents a hydrogen atom; or alternatively, R1 and R2 may combine together to form a cyclic structure and represent a C2-C3 alkylene chain.)
Inventors:
HIRAISHI KATSUYA (JP)
JIMMA FUMIE (JP)
SOMA HIROYUKI (JP)
ADACHI TARO (JP)
ADACHI MASAKAZU (JP)
YAMAOKA IPPEI (JP)
KAGAWA TOMOHIRO (JP)
JIMMA FUMIE (JP)
SOMA HIROYUKI (JP)
ADACHI TARO (JP)
ADACHI MASAKAZU (JP)
YAMAOKA IPPEI (JP)
KAGAWA TOMOHIRO (JP)
Application Number:
PCT/JP2016/004789
Publication Date:
May 11, 2017
Filing Date:
November 01, 2016
Export Citation:
Assignee:
ADABIO CO LTD (JP)
OTSUKA PHARMA FACTORY INC (JP)
OTSUKA PHARMA FACTORY INC (JP)
International Classes:
C07C235/12; A23L33/105; A61K31/197; A61K31/341; A61P1/18; C07C231/02; C07D207/416; C07D405/04
Domestic Patent References:
| WO2015052342A1 | 2015-04-16 | |||
| WO2016164437A1 | 2016-10-13 |
Foreign References:
| JP2011201841A | 2011-10-13 | |||
| JP2013201997A | 2013-10-07 |
Other References:
MIYAKE, MASAHARU ET AL.: "ISOLATION AND IDENTIFICATION OF beta-CITRYL-L-GLUTAMIC ACID FROM NEWBORN RAT BRAIN", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 544, 1978, pages 656 - 666, XP025787479, ISSN: 0304-4165
SCHMELZ, STEFAN ET AL.: "AcsD catalyzes enantioselective citrate desymmetrization in siderophore biosynthesis", NATURE CHEMICAL BIOLOGY, vol. 5, no. 3, 2009, pages 174 - 182, XP055384431, ISSN: 1552-4450
KONETSCHNY-RAPP, SILVIA ET AL.: "Staphyloferrin A: a structurally new siderophore from staphylococci", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 191, July 1990 (1990-07-01), pages 65 - 74, XP008014613, ISSN: 0014-2956
See also references of EP 3372578A4
SCHMELZ, STEFAN ET AL.: "AcsD catalyzes enantioselective citrate desymmetrization in siderophore biosynthesis", NATURE CHEMICAL BIOLOGY, vol. 5, no. 3, 2009, pages 174 - 182, XP055384431, ISSN: 1552-4450
KONETSCHNY-RAPP, SILVIA ET AL.: "Staphyloferrin A: a structurally new siderophore from staphylococci", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 191, July 1990 (1990-07-01), pages 65 - 74, XP008014613, ISSN: 0014-2956
See also references of EP 3372578A4
Attorney, Agent or Firm:
HIROTA, Masanori (JP)
Download PDF: