Title:
A NOVEL COLOSTRAL FRACTIONATION PROCESS
Document Type and Number:
WIPO Patent Application WO2005041680
Kind Code:
A3
Abstract:
A method (100) and a system (200) for processing mammalian bodily fluids to isolate target peptides and proteins. The method can include the steps of passing a mammalian bodily fluid through at least one ion exchange column (204). The ion exchange column can include an anionic resin and/or a cationic resin. The ion exchange column can be selected to remove large particles at a first pH level selected to remove such large particles at a maximum fluid pressure of (30) pounds per square inch (psi), for example less than (10) psi. The large particles can be released from the ion exchange column with a rinse solution having a pH selected for releasing the large particles. The pH of the fluid then can be adjusted to be a value less than 5.0, and the fluid can be filtered with a microfilter or ultrafilter (210).
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Inventors:
KEECH ANDREW (US)
JIMENEZ-FLORES RAFAEL (US)
JIMENEZ-FLORES RAFAEL (US)
Application Number:
PCT/US2004/036566
Publication Date:
January 05, 2006
Filing Date:
November 03, 2004
Export Citation:
Assignee:
ADVANCED PROTEIN SYSTEMS (US)
International Classes:
C02F1/44; C12P21/06; A23J; (IPC1-7): A61K38/43; C07K1/14; C07K16/04
Foreign References:
| US6010698A | 2000-01-04 |
Other References:
TAKAYAMA Y. ET AL: "Factors in bovine colostrum that enhance the migration of human fibroblast in type I collagen gels.", BIOSCI BIOTECHNOL BIOCHEM., vol. 65, no. 12, 2001, pages 2776 - 2779, XP002990774
JANUSZ M. ET AL: "Chemical and physical characterization of a proline-rich polypeptide from sheep colostrum.", BIOCHEM J., vol. 199, 1981, pages 9 - 15, XP002938312
KRUZEL M. ET AL: "The alcohol-induced conformational changes in casein micelles: a new challenge for the purification of colostrinin.", THE PROTEIN JOURNAL., vol. 23, no. 2, 2004, pages 127 - 133, XP008031778
JANUSZ M. ET AL: "Chemical and physical characterization of a proline-rich polypeptide from sheep colostrum.", BIOCHEM J., vol. 199, 1981, pages 9 - 15, XP002938312
KRUZEL M. ET AL: "The alcohol-induced conformational changes in casein micelles: a new challenge for the purification of colostrinin.", THE PROTEIN JOURNAL., vol. 23, no. 2, 2004, pages 127 - 133, XP008031778
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