Title:
NOVEL COMPOUND CERAMIDASTIN, PROCESS FOR PRODUCTION THEREOF, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2010/026873
Kind Code:
A1
Abstract:
Disclosed are: a novel compound having an excellent inhibitory activity against at least one of a neutral ceramidase and an alkaline ceramidase; a process for producing the compound; a novel microorganism capable of producing the novel compound; and a ceramidase inhibitor or a pharmaceutical composition comprising the novel compound. Specifically disclosed are: a compound characterized by being represented by structural formula (1); a process for producing the compound, which is characterized by comprising a culture step of culturing a microorganism belonging to the genus Penicillium and capable of producing the compound and a collection step of collecting the compound from a culture obtained in the culture step; and others.
Inventors:
INOUE HIROYUKI (JP)
KAWADA MANABU (JP)
IKEDA DAISHIRO (JP)
KAWADA MANABU (JP)
IKEDA DAISHIRO (JP)
Application Number:
PCT/JP2009/064459
Publication Date:
March 11, 2010
Filing Date:
August 18, 2009
Export Citation:
Assignee:
MICROBIAL CHEM RES FOUND (JP)
INOUE HIROYUKI (JP)
KAWADA MANABU (JP)
IKEDA DAISHIRO (JP)
INOUE HIROYUKI (JP)
KAWADA MANABU (JP)
IKEDA DAISHIRO (JP)
International Classes:
C12P17/18; A61K31/343; A61K36/06; A61P17/00; A61P37/08; C07D493/04; C12N1/14; C12N9/99
Domestic Patent References:
| WO2007029082A2 | 2007-03-15 |
Foreign References:
| JP2002284777A | 2002-10-03 | |||
| JPH08301862A | 1996-11-19 |
Other References:
BUECHI, G. ET AL.: "Structures of rubratoxins A and B.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 22, 1970, pages 6638 - 6641, XP008144329
INOUE, H. ET AL.: "Ceramidastin, a novel bacterial ceramidase inhibitor, produced by Penicillium sp. Mer-f17067.", J ANTIBIOT., vol. 62, February 2009 (2009-02-01), pages 63 - 67, XP008144328
See also references of EP 2330212A4
OKINO ET AL., J. BIOL. CHEM., vol. 273, 1998, pages 14368 - 14373
OKINO ET AL., J. BIOL. CHEM., vol. 274, 1999, pages 36616 - 36622
HIROI ET AL., JPN. J. PHARMACOL., vol. 76, 1998, pages 175 - 183
INOUE, H. ET AL.: "Ceramidastin, a novel bacterial ceramidase inhibitor, produced by Penicillium sp. Mer-f17067.", J ANTIBIOT., vol. 62, February 2009 (2009-02-01), pages 63 - 67, XP008144328
See also references of EP 2330212A4
OKINO ET AL., J. BIOL. CHEM., vol. 273, 1998, pages 14368 - 14373
OKINO ET AL., J. BIOL. CHEM., vol. 274, 1999, pages 36616 - 36622
HIROI ET AL., JPN. J. PHARMACOL., vol. 76, 1998, pages 175 - 183
Attorney, Agent or Firm:
HIROTA, Koichi et al. (JP)
Koichi Hirota (JP)
Koichi Hirota (JP)
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